Addictions

Chronic Pain Management: From Ancient Healing Practices to Advanced Medical Innovation.

Chronic pain is one of the most prevalent global health issues, significantly impacting physical and psychological health and resulting in reduced quality of life and a substantial economic burden on healthcare systems. Given its multifactorial nature, effective management of chronic pain requires a multidisciplinary approach to enhance treatment outcomes and reduce the long-term burden. This narr...

The use of the odds ratio product and self-reported data to detect comorbid insomnia and sleep apnea.

STUDY OBJECTIVES: To evaluate the utility of the odds ratio product (ORP) in differentiating comorbid insomnia and sleep apnea (COMISA) from obstructive sleep apnea (OSA) and chronic insomnia (CIN). METHODS: We retrospectively analyzed 9750 patients in four groups: (1) 1152 controls, (2) 2395 with CIN, (3) 2297 with OSA, and (4) 3906 with COMISA. CIN was defined as difficulty initiating/maintainin...

Prenatal alcohol exposure and the retrosplenial cortex: Structural and functional mechanisms across species.

The retrosplenial cortex (RSC) is a structurally and functionally complex hub with broad connectivity, integrating sensory inputs, cognitive states, a...

Updates on Kidney Transplantation From the World Transplant Congress 2025.

The World Transplant Congress 2025 showcased pivotal advances shaping the future of transplantation. Global efforts to expand access to transplantatio...

Bioinspired Structural Design Enables Synergistic Toughness and Conductivity in Hydrogels for Advanced Wearable Electronics.

Conductive hydrogels are revolutionizing the fields of wearable sensors, implantable bioelectronics, and soft robotics. However, achieving both mechan...

Does generative AI dependence foster creativity? Evidence from sports undergraduates.

As an emerging technological tool, generative AI profoundly reshapes higher education teaching and learning processes. Creativity, as a key component ...

Smelling decides: fMRI evidence reveals the influence of olfactory stimuli on risky decision-making.

BACKGROUND AND PURPOSE: Olfactory stimuli are known to have a significant effect on cognitive functions. However, their effect on risky decision-makin...

Development and validation of a fentanyl quantification model for drug checking services.

BACKGROUND: Drug checking services are becoming increasingly popular. Despite the significant variability in fentanyl concentrations observed in the u...

Effectiveness of AI-enhanced colonoscopy: A case-control study using real world evidence in a young screening age population.

BACKGROUND: Computer aided detection (CADe) colonoscopy has been shown in randomized controlled trials to improve detection of adenomatous colorectal ...

Protocol for Personalised Prediction of Persistent Postsurgical Pain.

INTRODUCTION: Persistent postsurgical pain (PPSP) affects up to 15% of patients after major surgery, impairing physical function, quality of life and ...

Near-infrared spectroscopy and machine-learning evaluation of PVA/β-TCP biomaterial composites.

A composite of polyvinyl alcohol (PVA) and beta-tricalcium phosphate (β-TCP) was synthesized as a biomaterial filament for 3D printers and its analyti...

Machine Learning Approach to Predict Pain Outcomes Following Primary and Secondary Targeted Muscle Reinnervation in Amputees.

INTRODUCTION: Targeted Muscle Reinnervation (TMR) can prevent and treat neuropathic pain in amputees, but the degree of success varies. This study dev...

Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test-Based Organized Screening Program in Italy: A Randomized Control Trial.

BACKGROUND: The fecal immunochemical test (FIT) is widely implemented as a first-line tool in organized colorectal cancer (CRC) screening programs, in...

Machine learning-based risk factors for acute-on-chronic liver failure in alcohol-associated liver disease.

BACKGROUND: In patients with alcohol-associated liver disease (ALD), heavy and prolonged alcohol consumption can trigger acute-on-chronic liver failur...

From non-specific biomarker to targeted action: transdiagnostic and sex-specific drivers of high-CRP status in severe mental illness across the FondaMental Advanced Centers of Expertise (FACE) cohorts.

BACKGROUND AND OBJECTIVES: Low-grade systemic inflammation contributes to the pathophysiology of severe mental illness (SMI) in a substantial subset o...

Investigation of Bias Using ChatGPT-4 in Pain Management and Patient Profiling.

BACKGROUND: Large language models, such as ChatGPT (cGPT), are being integrated increasingly into clinical workflows and medical education. However, c...

Descriptive content analysis assessment of ChatGPT responses to substance use disorder treatment questions compared to National health guidelines.

BACKGROUND: Artificial intelligence (AI)-powered large language models like ChatGPT are increasingly used by the public to access health information. ...

Machine learning prediction of food addiction in university students using demographic, anthropometric and personality traits.

People's eating habits are influenced by psychological, social, cultural, and behavioral factors. Research shows that certain personality types expose...

Evaluating the methodological suitability of partial dependence plots and Shapley additive explanations for population-level interpretation of machine learning models in total joint arthroplasty.

BACKGROUND: Total joint arthroplasty (TJA) complications necessitate the development of accurate risk prediction models; however, interpretability in ...

Multicenter Prospective Cohort Study on Clinical Outcomes and Fibrosis Patterns in Biopsy-Proven Steatotic Liver Disease Subtypes.

BACKGROUND & AIMS: Clinical outcomes and histological characteristics of biopsy-proven steatotic liver disease (SLD) subtypes remain understudied. We ...