Pediatrics

ADHD/ADD

Latest AI and machine learning research in adhd/add for healthcare professionals.

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Language network functional connectivity in infancy predicts developmental language trajectories

Although developmental language delays affect approximately 10% of children in the general population, the neurodevelopmental mechanisms that support normative language acquisition, and atypicalities that may predict later language delay, across the first year of life are poorly understood. Here, resting-state fMRI data from the Baby Connectome Project was used to evaluate age-related changes in l...

PATTY corrects open chromatin bias for improved bulk and single-cell CUT&Tag profiling

Precise profiling of epigenomes is essential for better understanding chromatin biology and gene regulation. Cleavage Under Targets & Tagmentation (CUT&Tag) is an efficient epigenomic profiling technique that can be performed on a low number of cells and at the single-cell level. With its growing adoption, CUT&Tag datasets spanning diverse biological systems are rapidly accumulating in the field. ...

Cross-Species Insights from ART-D to Uncover Evolutionarily Conserved Oncogenic Mechanisms

Cancer arises from oncogenic clones, yet the dynamic mechanisms governing their stepwise evolution toward malignancy remain incompletely understood. H...

Deep Learning of Brain-Behavior Dimensions Identifies Transdiagnostic Biotypes in Youth with ADHD and Anxiety Disorders

Attention-deficit/hyperactivity disorder and anxiety disorders are highly prevalent in youth and are characterized by substantial heterogeneity and fr...

Active Sampling and Sex Differences in Perceptual Decision Making in Rats

Decisions are typically viewed as arising from a sequential process: perception, decision, and then action. However, an alternative perspective, drawi...

Digital Twin Approaches for Interpretable Side Effect Prediction in Drug Discovery

Artificial intelligence plays an ever-greater role in preclinical drug development, ranging from target identification and molecule design to ADME-Tox...

Neural trajectories improve motor precision

Populations of neurons in motor cortex signal voluntary movement. Most classic neural encoding models and current brain-computer interface decoders as...

ADHD Medications and Preadolescent Brain Structure: Patterns of Cortical Attenuation from the ABCD Study

Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in the U.S., and the stimulant and nonstimulant medicat...

Enigma: An Efficient Model for Deciphering Regulatory Genomics

Genomic sequence-to-function models have emerged as powerful tools for deciphering cis-regulatory grammar to advance our understanding of disease biol...

Encoding and Decoding of Brain Dynamic Functional Connectivity for ADHD Diagnosis

Recent studies have demonstrated strong associations between the changes in dynamic functional connectivity (FC) and both behavioral and cognitive fun...

How Much Does Protein Structure Really Help? A Case Study in Mutation-Induced Stability Prediction

Multimodal neural networks integrating protein language models (PLMs) with structure-derived features are increasingly common for predicting mutation ...

Multi-modal, multi-species, and multi-task latent-space model for decoding level of consciousness

Assessing the degree and characteristics of consciousness is central to caring for patients with Disorders of Consciousness (DoC), yet current standar...

MeLSI: Metric Learning for Statistical Inference in Microbiome Community Composition Analysis

Microbiome beta diversity analysis relies on distance-based methods including PERMANOVA combined with fixed ecological distance metrics (Bray-Curtis, ...

Temporal Dynamics of High-Frequency Oscillations in Alzheimer’s Disease: A Longitudinal Study in hAPP-J20 Mice

Alzheimer’s disease (AD) is characterized by progressive cognitive decline and increased seizure susceptibility; yet both the mechanistic and temporal...

Enhancing Brain Age Estimation Under Uncertainty: A Spectral-normalized Neural Gaussian Process Approach Utilizing 2.5D Slicing

Brain age gap, the difference between estimated brain age and chronological age via magnetic resonance imaging, has emerged as a pivotal biomarker in ...

Tumor-infiltrating lymphocytes in breast cancer through artificial intelligence: biomarker analysis from the results of the TIGER challenge

The prognostic significance of tumor-infiltrating lymphocytes (TILs) in breast cancer has been recognized for over a decade. Although histology-based ...

Adherence Risk Stratification in Physiatry: A Multivariate Analysis of Factors in Community-Based Care Using Algorithmic Modeling Techniques

Missed appointments represent a double-edged sword in community health settings. Policies designed to retain patients and ensure continuity of care fo...

Deep learning-based polygenic scores enhance generalizability of psychiatric disorders prediction

Polygenic scores (PGSs) have emerged as promising tools for predicting complex traits from genetic data, however, their predictive performance for psy...

Lack of children in public medical imaging data points to growing age bias in biomedical AI

Artificial intelligence (AI) is rapidly transforming healthcare, but its benefits are not reaching all patients equally. Children remain overlooked wi...

A conversational artificial intelligence agent for medication reconciliation and review

Medication reconciliation, the process of creating an accurate medication list for a patient, is critical to patient safety and care quality but requi...

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