Allergy & Immunology

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole-Blood RNA Transcriptome.

OBJECTIVE: Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)-positive patients using whole-blood transcriptomics. METHODS: Whole-blood RNA sequencing was performed on 174 aPL-...

artificial intelligence-enabled precision medicine for inflammatory skin diseases.

Recent advances in artificial intelligence (AI) and multimodal data collection are revolutionizing dermatology. Generative AI and machine-learning approaches offer opportunities to enhance the diagnosis and treatment of autoimmune and inflammatory skin diseases, including atopic dermatitis, psoriasis, hidradenitis suppurativa, vitiligo, alopecia areata, and rheumatic skin disease. This review exam...

Beyond handcrafted radiomics in oncologic imaging: Innovations in deep, explainable, multi-site and multi-omics radiomics approaches.

Radiomics seeks to convert medical images into quantitative biomarkers capable of capturing tumor phenotype, microenvironment, and underlying biology....

Automating classification of treatment responses to combined targeted therapy and immunotherapy in HCC.

Tyrosine kinase inhibitor (TKI) combined with immunotherapy regimens are now widely used for treating advanced hepatocellular carcinoma (HCC), but the...

Improving machine-learning development in allergology: bridging the gap between open-access and cohort-based databases.

PURPOSE OF REVIEW: The advent of high-throughput data generation and artificial intelligence has transformed allergy research. Open-access database (O...

The use of advanced machine learning to predict outcomes after atezolizumab plus bevacizumab for advanced hepatocellular carcinoma: a retrospective cohort study.

BACKGROUND: Combination immune checkpoint inhibitors are recommended as first-line therapy for advanced hepatocellular carcinoma. However, only a thir...

Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcome in Sarcoma.

PURPOSE: Immune checkpoint blockade (ICB) benefits only a subset of sarcoma patients. Biomarkers of response and resistance are needed to help guide p...

Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profiling.

BACKGROUND: The COVID-19 pandemic offers a powerful opportunity to develop methods for monitoring the spread of infectious diseases based on their sig...

epiGPTope: A Machine Learning-Based Epitope Generator and Classifier.

Epitopes are short antigenic peptide sequences that are recognized by antibodies or immune cell receptors. These are central to the development of imm...

Projected typical allergic diseases prevalence under changing environments based on multiple machine learning models.

Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker.

BACKGROUND: Endometrial cancer (EC) is a common gynecological tumor. Insulin resistance (IR) increases the risk of EC. However, the common molecular b...

Advancing prussian blue nanoparticle-mediated photothermal therapy through machine learning and multiomics integration.

Prussian blue nanoparticles (PBNPs) are a versatile platform for administering photothermal therapy (PTT) in cancer therapy applications. PBNPs combin...

Predictive modeling of molecular activity underlying physical cell-cell interactions.

Interactions between cells are central to tissue organization and function in health and disease. Labeling immune partnerships by sortagging intercell...

Atopic Dermatitis in Denmark: Regional Variation.

Using national registers, this study investigates regional variations in the number of individuals with and treatment of atopic dermatitis (AD) in Den...

Evaluation of large Language models on pediatric asthma: a comparative study of Claude3-Opus, Gemini 2.0, ChatGPT-4o, and DeepSeek-a cross-sectional questionnaire study.

The use of the odds ratio product and self-reported data to detect comorbid insomnia and sleep apnea.

STUDY OBJECTIVES: To evaluate the utility of the odds ratio product (ORP) in differentiating comorbid insomnia and sleep apnea (COMISA) from obstructi...

Integrative bioinformatics and experiments identify RIBC2 as a key regulator in the esophageal cancer.

Early detection of esophageal cancer (EC) remains a major challenge due to the limited understanding of its initial molecular alterations. Therefore, ...

Proteomics-driven innovations in plant-based foods: Current advances, emerging technologies, and future perspectives.

Despite rapid market growth, plant-based foods such as meat analogs, plant-based milk, yogurt alternatives, and fermented products still fall short of...

Inhibition of the p38/JNK MAPK pathway mediated by circadian rhythm genes: Study of the mechanism of Linggan Wuwei Jiangxin decoction in the treatment of COPD.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a frequently encountered respiratory disease. Its clinical symptoms ar...

Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.

BACKGROUND: Liver fibrosis and acute myocardial infarction (AMI) tended to co-occur. Cellular senescence and an imbalanced immune microenvironment wer...