Allergy & Immunology

Latest AI and machine learning research in allergy & immunology for healthcare professionals.

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scHDeepInsight: A Hierarchical Deep Learning Framework for Precise Immune Cell Annotation in Single-Cell RNA-seq Data

Immune cell classification from single-cell RNA sequencing (scRNA-seq) presents significant challeng...

Deep generative modeling reveals maturation-linked pairing signatures in human antibodies

Understanding how antibody heavy and light chains pair is critical for decoding immune repertoire ar...

Quantum Convolutional HLA Immunogenic Peptide Prediction (Q-CHIPP): Next-Generation Neoantigen Prediction with Quantum Neural Networks

The immune system is an intricately evolved series of cellular and protein-protein interactions, whi...

Multivariate pattern analysis reveals resting-state EEG biomarkers in fibromyalgia

Fibromyalgia (FM) involves widespread musculoskeletal pain and hypersensitivity, often accompanied b...

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy

Chimeric antigen receptor (CAR) T cell therapy holds transformative potential for hematologic malign...

Rapid CE–MS with Real-Time Eco–AI Resolves Proteomic Heterogeneity Among Single Human Neutrophils

Single-cell proteomics by mass spectrometry is advancing rapidly, yet throughput and sensitivity rem...

Reengineering the antigen optimization process for superior neoantigen vaccine design

Identifying effective neoantigen sequences is essential for enhancing anti-tumor immunity. However, ...

BRAVE: a highly accurate method for predicting HIV-1 antibody resistance using large language models for proteins

Broadly neutralizing antibodies (bNAbs) that target the envelope glycoprotein (Env) of human immunod...

Antibody immunogenicity prediction and optimization with ImmunoSeq

Therapeutic antibody development faces persistent immunogenicity challenges from anti-drug antibodie...

The hidden predictors of human haematopoietic clonal fate

Human haematopoietic stem and progenitor cells (HSPCs) exhibit heterogeneous lineage output, but the...

Translating clinical gene sequencing into a foundational representation of tumor subtype

While gene sequencing is routine in cancer care, translating sequences into treatment decisions rema...

SpaPheno: Linking Spatial Transcriptomics to Clinical Phenotypes with Interpretable Machine Learning

Linking spatial transcriptomic data to clinically relevant phenotypes is essential for advancing spa...

BLMPred: predicting linear B-cell epitopes using pre-trained protein language models and machine learning

B-cells get activated through interaction with B-cell epitopes, a specific portion of the antigen. I...

Fourier transform infrared spectroscopy enables rapid species discrimination across Malassezia and strain-level typing in M. pachydermatis

Malassezia pachydermatis is a zoophilic yeast found on the skin and in the outer ear canal of many m...

T-SCAPE: T-cell Immunogenicity Scoring via Cross-domain Aided Predictive Engine

T-cell immunogenicity, the ability of peptide fragments to elicit T-cell responses, is a critical de...

Accurate and scalable multi-disease classification from adaptive immune repertoires

Machine learning models trained on paratope-similarity networks have shown superior accuracy compare...

Pocket Restraints Guided by B-Cell Epitope Prediction Improves Chai-1 Antibody-Antigen Structure Modeling

The accurate prediction of antibody-antigen (AbAg) complexes is a key challenge for computational im...

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