Allergy

Development and Interpretation of a Machine Learning-Based Predictive Model Using Clinical Parameters for Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.

ObjectiveWe aim to predict eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) employing...

Decoding the immune-tumor synapse for data-driven design of next-generation immunotherapies.

The immunological synapse (IS) formed between cytotoxic CD8+ T lymphocytes (CTLs) and tumor cells re...

Immune checkpoint molecules beyond PD-1 and CTLA-4: emerging targets in autoimmune diseases and cancer immunotherapy.

BACKGROUND: Immune checkpoint molecules are pivotal regulators of immune activation and tolerance, p...

Computational Innovations in Cancer Research and How Computing is Transforming Drug Discovery and Development: A Review.

INTRODUCTION: Cancer is a major global health concern, causing millions of deaths each year due to t...

Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment.

Cancer is an evolutionary process characterized by profound intratumor heterogeneity (ITH), which ca...

Loop of N2-polarized neutrophils and exhausted CD8 + T cells induces immunotherapy resistance in NSCLC.

While neutrophils represent a prominent myeloid component in non-small cell lung cancer (NSCLC), the...

Immune-activated & pathology-characterized: the distinct clear cell renal cell carcinoma subtypes for 3PM strategies derived from artificial intelligence in multi-omics.

BACKGROUND AND OBJECTIVE: Renal clear cell carcinoma (ccRCC) is highly heterogeneous, with significa...

CT-based radiomics for predicting the treatment response to PD-1/PD-L1 inhibitors combined with chemotherapy in unresectable gastric cancer.

OBJECTIVE: To develop and validate a CT-based radiomics model to predict immunotherapy response in u...

A lactylation-related gene signature predicts prognosis and immunotherapy response in clear cell renal cell carcinoma based on machine learning and multi-omics analysis.

Molecular and immunological heterogeneity of eosinophilic esophagitis: Insights and subtyping.

BACKGROUND: Eosinophilic esophagitis (EoE) and its related subtypes-such as EoE-like esophagitis, ly...

Optimization and validation of air impingement cleaning parameters for removing nonfat dry milk powder from stainless steel surfaces by machine learning.

Air impingement cleaning can remove residues from food contact surfaces without introducing moisture...

Automated auditing of emergency department documentation using large language models.

INTRODUCTION: Errors in emergency department (ED) documentation can lead to patient harm and medicol...

TRIM36 and CAMK2N2 regulate ferroptosis and antigen presentation in small cell lung cancer.

Small cell lung cancer (SCLC) is a highly aggressive tumor with poor prognosis. Ferroptosis is close...

Artificial intelligence-assisted spatial omics-based biomimetic nanoplatform for intelligent and precise intervention in the immunosuppressive core region of ovarian cancer.

Ovarian cancer (OC) ranks among the most aggressive malignancies of the female reproductive system. ...

Targeting metabolism to combat anticancer and antibacterial drug resistance.

Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutio...

Label-Free Raman Spectral Identification of NK and NKT Cells in Immune Heterogeneous Cell Populations.

NK and NKT cells act as major effector subsets across multiple immune heterogeneous cell populations...

CT image-based machine learning models for predicting blood eosinophil levels in acute exacerbation of chronic obstructive pulmonary disease.

Hematologic Patterns in Differentiating DRESS From Morbilliform Drug Eruptions: A Preliminary Investigation.

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) and morbilliform drug erup...

Future Perspectives for Artificial Intelligence in Allergy: Advances in Diagnosis, Monitoring, and Personalized Care.

Artificial intelligence (AI) is significantly transforming the specialty of allergy by offering nove...

GOLD 2026: Transforming COPD Management with Early Intervention, Multi-dimensional Assessment, and Personalized Care.

The 2026 report from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) introduces su...

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remode...