Allergy

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remodeling. However, its therapeutic potential in enhancing immune checkpoint inhibitor (ICI) efficacy remains incompletely understood and warrants further investigation. METHODS: To investigate the potential of ferroptosis in improving ICI response, we constructed a machine learning-based predictive mode...

Precision immunotherapies for systemic lupus erythematosus: From pathogenic targets to translational horizons.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder in which aberrant B-cell activation, persistent autoantibody production, and dysregulated cytokine and intracellular signaling networks converge to produce relapsing-remitting, multisystem inflammation and cumulative organ damage. Although conventional immunosuppressants remain the backbone of care and can attenuate disease ...

Effects of Environmental Factors on Incidence of Allergic Rhinitis and Chronic Rhinosinusitis: A Comparative Study.

OBJECTIVE: To investigate the associations of air pollutants and meteorological factors with outpatient visits for allergic rhinitis (AR) and chronic ...

Role of the gut microbiome in shaping drug response in immunocompromised hosts.

BACKGROUND: There is an increasing amount of evidence on microbiome-drug interactions in several clinical settings, including in immunocompromised pat...

Enhancing adverse drug event extraction and summarization for cancer drugs through large language models.

PURPOSE: Cancer treatments such as chemotherapy, targeted therapy, and immunotherapy can effectively combat malignant cells but frequently cause serio...

The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review).

The interaction between autophagy and ferroptosis has resulted in the identification of novel approaches for the treatment of lung cancer (LC). The tw...

Heterogeneous Multilayer Nanopores via Chemically Tuned Dielectric Breakdown for Single-Molecule Sensing.

Solid-state nanopores are powerful platforms for single-molecule sensing, yet their performance is often constrained by fabrication complexity, noise,...

Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

PURPOSE: Personalized immunotherapy strategies are urgently needed for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We aim to...

Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice.

Spinal cord injury (SCI) causes multifaceted postural and motor impairments that are challenging to quantify. Conventional behavioral tests, such as t...

Context-Aware adaptive normalization LSTM (CAAN-LSTM) for immunotherapy decision support in cancer clinical data analysis.

BACKGROUND: Clinical decision-making for cancer immunotherapy is challenged by the heterogeneous and often incomplete nature of patient time-series da...

Decoding the Microbiome-Disease Axis with Interpretable Graph Neural Networks.

AIMS: The human gut microbiome is a complex ecosystem whose disruption is implicated in a wide spectrum of diseases, yet translating microbiome resear...

Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer.

Immunotherapy with immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC) shows limited clinical benefit only for a small subset of pa...

Neoadjuvant Systemic Therapy in Kidney and Bladder Cancer: Current Evidence and Emerging Paradigms.

Neoadjuvant systemic therapy has emerged as a strategy to improve outcomes in high-risk localized genitourinary malignancies. In bladder cancer, neoad...

Integrating machine learning of bulk and single cell RNA data to characterize immune mechanism of m6A related mitophagy genes in malignant gastric cancer.

BACKGROUND AND OBJECTIVE: Gastric cancer is a heterogeneous and complicated epithelial cancers. Chronic H. pylori and EBV infection, as well as intest...

TCR sequencing in cancer immunology and immunotherapy: what, when, where, why, and how.

T-cell receptors (TCRs) are generated through somatic recombination of variable (V), diversity (D), and joining (J) gene segments, resulting in an ext...

A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.

Salivary gland carcinomas (SGC) are rare and heterogeneous tumors with limited therapeutic options in advanced stages. Recent evidence suggests a pote...

GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma.

Despite the increasing recognition of pyroptosis, particularly that involving GSDME, its precise impact on tumor prognosis and the immune microenviron...

Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma.

Hepatocellular carcinoma remains a leading cause of cancer mortality worldwide, with peritumoral microenvironment interactions playing a critical role...

Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.

UNLABELLED: Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In thi...

Developing a Metabolic-Associated Prognostic Index for Risk Stratification and Therapeutic Guidance in Stage I Lung Adenocarcinoma via Multiomics Analysis.

PURPOSE: Early-stage lung adenocarcinoma (LUAD) exhibits substantial clinical heterogeneity that is not fully explained by TNM staging, highlighting t...