Latest AI and machine learning research in allergy for healthcare professionals.
This review examines how biotechnology advances (CRISPR/Cas9, next-generation targeted therapies, nanotechnology-based drug delivery, and immunotherapies) can be applied to address cancer drug resistance worldwide. It also considers the economic burden of resistance, inequities in access to biotechnology solutions, and ethical concerns surrounding rapid innovation, particularly in low-resource set...
Esophageal squamous cell carcinoma (ESCC) remains a major health burden, particularly in Asia, with poor patient prognosis despite advancements in radiotherapy, chemotherapy, and immunotherapy. The marked inter-patient and intra-tumor heterogeneity of ESCC underscores the need for molecularly informed diagnostic and therapeutic strategies. Recent high-throughput omics technologies, including genom...
Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, ranks as the fourth leading cause of cancer-associated mortality globall...
Tumor Mutational Burden (TMB) is a widely used biomarker for selecting cancer patients for immune checkpoint inhibitor (ICI) therapy. However, TMB alo...
Immune checkpoint inhibitors (ICI) have improved clinical outcomes for some patients with advanced NSCLC, however a substantial proportion of patients...
This study systematically predicts prognosis and key gene targets for immunotherapy in hepatocellular carcinoma (HCC) patients based on the joint scre...
BACKGROUND: Emerging evidence highlights the significant role of Neutrophil Extracellular Traps (NETs) in hepatocellular carcinoma (HCC), but the unde...
OBJECTIVES: Urbanization-related air pollution may be associated with olfactory dysfunction (OD) in China, yet population studies are lacking. METHODS...
The epidermal growth factor receptor (EGFR) is a key target in cancer therapy, mainly in non-small cell lung cancer (NSCLC). Though, the efficacy of E...
PURPOSE: Endoscopically identifying eosinophilic esophagitis (EoE) is difficult due to its rare incidence and subtle morphology. We aimed to develop a...
The discovery of natural killer (NK) cells stands among the fundamental milestones in modern immunology. To mark the 50-year anniversary of the first ...
Recent advancements in cancer immunotherapy have transformed clinical oncology, with monoclonal antibodies (mAbs), immune checkpoint inhibitors, adopt...
INTRODUCTION: Proton pump inhibitors (PPIs) are widely used to treat acid-related disorders; however, treatment response varies significantly due to C...
BACKGROUND: Hymenoptera venom immunotherapy is an established treatment for severe allergic reactions, aiming to modulate the immune response and redu...
In contrast to the MSI-H subtype, most microsatellite-stable (MSS) colorectal cancer (CRC) patients exhibit poor prognosis and limited responsiveness ...
Lung adenocarcinoma (LUAD) displays significant morphological and molecular heterogeneity both within and between tumors. This heterogeneity, coupled ...
Recent innovations in skin microphysiological systems (MPSs) have gained momentum following regulatory advances such as the FDA Modernization Act 2.0 ...
Aging and age-related diseases are a major public health concern, driving interest in anti-aging research. While small molecules and natural compounds...
Immunotherapy, a therapeutic strategy aimed at modulating the host immune system, has undergone rapid evolution over recent decades, particularly in o...
Mushrooms are rich in structurally diverse bioactive compounds that exert potent immunomodulatory effects, making them promising candidates for next-g...