Allergy

Computational Approaches to Penicillin Allergy De-labelling: A Clinical Review.

Penicillin allergy is recorded in roughly one in ten hospital patients, yet fewer than one in ten of...

Application of aiAtlas Version 1.2 to Simulate Variant Gene Function Restoration and Rescue Thresholds in Rare Diseases: Validation Case Study.

BACKGROUND: Xeroderma pigmentosum group D (XPD), caused by ERCC2 gene dysfunction, leads to defectiv...

[Allergy Prevention L·OVE: Development of a structured, publicly accessible evidence repository for allergy prevention].

BACKGROUND: The prevention of allergic diseases has been addressed by numerous systematic reviews. H...

[Oncology Society of Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2026 edition)].

To further standardize the prevention and management of lung cancer in China, improve the level of d...

Mesenchymal Tumors Feature a Spatially Defined Glial-Tip Cell Niche Around the Tumor Boundary in Microsatellite-Stable Colorectal Cancer.

Colorectal cancers (CRC) with microsatellite stability (MSS) and instability (MSI) differ in tumor m...

Neoantigen cancer vaccines for gastrointestinal tumors: opportunities and challenges.

Gastrointestinal tumors are characterized by high global incidence and mortality rates. Although imm...

Evaluating the role of ChatGPT in patient questions regarding drug allergies.

BACKGROUND: The use of artificial intelligence (AI) technology is increasing. It takes patients with...

CT-based deep foundation model for predicting immune checkpoint inhibitor-induced pneumonitis risk in lung cancer.

BACKGROUND: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but can cause se...

A medically grounded LLM agent-based tool to detect patient safety events in medical records.

Large language models (LLMs) have shown incredible promise in medicine. While LLMs may be particular...

Efflux pump gene ABCA as targets for deep learning-based de novo inhibitors in invasive aspergillosis caused by Aspergillus fumigatus.

This study aims to design and evaluate novel therapeutic binders targeting the ATP-binding region of...

Comment on "Retrieval-augmented generative AI enhances clinical reasoning in odontogenic sinusitis versus maxillary sinus mucositis".

Factors beyond anthropogenic climate change affecting airborne pollen levels in urban areas.

Climate change is increasing airborne pollen concentrations, exposing populations to unprecedented a...

Identification of broadly tumour-reactive γδ TCRs from multiple myeloma.

γδ T cells are becoming increasingly appreciated for their antitumour capacity and role in mediating...

Epigenetic mechanisms and clinical translation in ovarian cancer: from molecular pathways to precision therapy.

Ovarian cancer remains one of the deadliest gynecological malignancies, mainly due to its late diagn...

The evolving role of immunotherapy in ovarian cancer.

Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoin...

Stratifying lung adenocarcinoma: a novel prognostic model based on mitochondrial outer membrane permeabilization activity.

UNLABELLED: Mitochondrial outer membrane permeabilization (MOMP) is a core apoptotic regulatory even...

Inflammation biomarkers in cancer: mechanistic drivers, diagnostic innovations, and future clinical horizons.

Chronic inflammation is a universally acknowledged characteristic of cancer, playing the role of a v...

Exploring novel and evolved tools in atopic dermatitis diagnosis.

INTRODUCTION: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and is cli...

Deep learning-based CT model for non-invasive prediction of tertiary lymphoid structures in pancreatic cancer: a multicenter study with prospective validation in an immunochemotherapy cohort.

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Ter...

A bioinformatic single-cell and structure-informed framework identifies a baicalin-CA2-keratinocyte state axis in atopic dermatitis.

Atopic dermatitis (AD) is characterized by a self-reinforcing loop between epidermal barrier dysfunc...

Ultrasound Molecular Imaging and Visualization of Immune Biomarkers: A New Paradigm for Tumor Immunotherapy Response Assessment.

Cancer immunotherapy has revolutionized the treatment landscape, yet its clinical efficacy is limite...