Allergy

Development and characterization of methoxy poly(ethylene oxide)--poly(ε-caprolactone) (PEO--PCL) micelles as vehicles for the solubilization and delivery of tacrolimus.

Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4-12 μg/mL), low and variable oral bioavailability in patients, and narrow therapeutic window that could not be solved by the currently available formulation (Prograf®). Moreover, Prograf® contains HCO-60 (PEGylated castor oil) as a surfactant, which is reported to cause several side...

Feature Extraction and Machine Learning for the Classification of Brazilian Savannah Pollen Grains.

The classification of pollen species and types is an important task in many areas like forensic palynology, archaeological palynology and melissopalynology. This paper presents the first annotated image dataset for the Brazilian Savannah pollen types that can be used to train and test computer vision based automatic pollen classifiers. A first baseline human and computer performance for this datas...

Localizing Tortoise Nests by Neural Networks.

The goal of this research is to recognize the nest digging activity of tortoises using a device mounted atop the tortoise carapace. The device classif...

Use of a Robotic Sampler (PIPER) for Evaluation of Particulate Matter Exposure and Eczema in Preschoolers.

While the association of eczema with asthma is well recognized, little research has focused on the potential role of inhalable exposures and eczema. W...

Evaluation of surgical treatment of carpal tunnel syndrome using local anesthesia.

OBJECTIVE: To evaluate the results and complications from surgical treatment of carpal tunnel syndrome by means of an open route, using a local anesth...

Amelogenesis Imperfecta: Rehabilitation and Brainstorming on the Treatment Outcome after the First Year.

Amelogenesis imperfecta (AI) affects enamel on primary and permanent dentition. This hereditary disorder is characterized by loss of enamel, poor esth...

Yolk sac tumor of the external auditory canal: a case report and literature review.

We report one case of yolk sac tumor of the ear and review the literature. The patient was a 9-month boy who scratched his right ear repeatedly one mo...

Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6.

The fetal tight junction molecule claudin 6 (CLDN6) is virtually absent from any normal tissue, whereas it is aberrantly and frequently expressed in v...

Discrimination of Brazilian propolis according to the seasoning using chemometrics and machine learning based on UV-Vis scanning data.

Propolis is a chemically complex biomass produced by honeybees (Apis mellifera) from plant resins added of salivary enzymes, beeswax, and pollen. The ...

Identification of novel Xanthomonas euvesicatoria type III effector proteins by a machine-learning approach.

The Gram-negative bacterium Xanthomonas euvesicatoria (Xcv) is the causal agent of bacterial spot disease in pepper and tomato. Xcv pathogenicity depe...

Enzymatic treatment of soy protein isolates: effects on the potential allergenicity, technofunctionality, and sensory properties.

Soybean allergy is of great concern and continues to challenge both consumer and food industry. The present study investigates the enzyme-assisted red...

FoodWiki: Ontology-Driven Mobile Safe Food Consumption System.

An ontology-driven safe food consumption mobile system is considered. Over 3,000 compounds are being added to processed food, with numerous effects on...

Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches.

Drug-induced eosinophilia is a potentially life-threatening adverse effect; clinical manifestations, eosinophilia-myalgia syndrome, mainly include sev...

Selective determination of dimenhydrinate in presence of six of its related substances and potential impurities using a direct GC/MS method.

A novel simple, direct and selective gas chromatography-mass spectrometry (GC/MS) procedure was developed for the determination of the antihistamine d...

Robot-assisted therapy for improving social interactions and activity participation among institutionalized older adults: a pilot study.

INTRODUCTION: Animal-assisted therapy is gaining popularity as part of therapeutic activities for older adults in many long-term care facilities. Howe...

Surprisal-based large language models reveal immunologic insights in lobular breast cancer

In large data sets discovery is often limited to pre-conceived hypotheses and data fishing. Here we tested whether systematic exploration of AI genera...

Towards a ML-powered Multiscale Computational Platform Based on QSP and PBPK Modeling to Support the Development of mRNA-based Therapies

mRNA-based therapeutics have emerged as a transformative class of medicines, yet their translation beyond infectious disease vaccines remains challeng...

A Point-of-Prescription Safety-Check System for Adverse Drug Reactions in Rural Bangladeshi Hospitals: A Feasibility Study

Adverse drug reactions (ADRs) are a major, largely preventable source of patient harm. In high-income settings, electronic health records store a pati...

Optimizing RNA yield using deep neural networks coupled to massively parallel screening

Messenger RNA (mRNA)-based therapeutics have emerged as a powerful platform for vaccines, protein replacement therapies, and cancer immunotherapy. A c...

SANE: State Anomaly Neutralization for Stable Extreme-Context Delta-Rule Models

Delta-Rule recurrent models maintain a fixed-size state, enabling $O(1)$ inference memory but potentially becoming unstable under extreme-context extr...