Alzheimer's Disease

A machine learning-based linguistic battery for diagnosing mild cognitive impairment due to Alzheimer's disease.

There is a limited evaluation of an independent linguistic battery for early diagnosis of Mild Cognitive Impairment due to Alzheimer's disease (MCI-AD). We hypothesized that an independent linguistic battery comprising of only the language components or subtests of popular test batteries could give a better clinical diagnosis for MCI-AD compared to using an exhaustive battery of tests. As such, we...

The Effect of Using PARO for People Living With Dementia and Chronic Pain: A Pilot Randomized Controlled Trial.

OBJECTIVES: To evaluate the effect of interaction with a robotic seal (PARO) on pain and behavioral and psychological symptoms of people with dementia and chronic pain.

A novel CNN based Alzheimer's disease classification using hybrid enhanced ICA segmented gray matter of MRI.

Predicting Alzheimer's Disease (AD) from Mild Cognitive Impairment (MCI) and Cognitive Normal (CN) has become wide. Recent advancement in neuroimaging...

Prediction of caregiver burden in amyotrophic lateral sclerosis: a machine learning approach using random forests applied to a cohort study.

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that is characterised by the rapid degeneration of upper and lower...

A proof of concept machine learning analysis using multimodal neuroimaging and neurocognitive measures as predictive biomarker in bipolar disorder.

BACKGROUND: Concomitant use of complementary, multimodal imaging measures and neurocognitive measures is reported to have higher accuracy as a biomark...

GenEpi: gene-based epistasis discovery using machine learning.

BACKGROUND: Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However,...

A combination of 3-D discrete wavelet transform and 3-D local binary pattern for classification of mild cognitive impairment.

BACKGROUND: The detection of Alzheimer's Disease (AD) in its formative stages, especially in Mild Cognitive Impairments (MCI), has the potential of he...

Measuring the impact of age, gender and dementia on communication-robot interventions in residential care homes.

AIM: The primary aim of this study was to examine the impact of age, gender and the stage of dementia on the results of an assistive technology interv...

Identifying treatment effects of an informal caregiver education intervention to increase days in the community and decrease caregiver distress: a machine-learning secondary analysis of subgroup effects in the HI-FIVES randomized clinical trial.

BACKGROUND: Informal caregivers report substantial burden and depressive symptoms which predict higher rates of patient institutionalization. While ca...

Multimodal Data Analysis of Alzheimer's Disease Based on Clustering Evolutionary Random Forest.

Alzheimer's disease (AD) has become a severe medical challenge. Advances in technologies produced high-dimensional data of different modalities includ...

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.

INTRODUCTION: Developing cross-validated multi-biomarker models for the prediction of the rate of cognitive decline in Alzheimer's disease (AD) is a c...

Deep Learning Prediction of Mild Cognitive Impairment using Electronic Health Records.

About 44.4 million people have been diagnosed with dementia worldwide, and it is estimated that this number will be almost tripled by 2050. Predicting...

Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.

Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and ...

Shaping technologies for older adults with and without dementia: Reflections on ethics and preferences.

As a result of several years of European funding, progressive introduction of assistive technologies in our society has provided many researchers and ...

A Novel Deep Learning Approach with a 3D Convolutional Ladder Network for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease.

PURPOSE: Idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) are geriatric diseases and common causes of dementia. Recently, ...

A survey on machine and statistical learning for longitudinal analysis of neuroimaging data in Alzheimer's disease.

BACKGROUND AND OBJECTIVES: Recently, longitudinal studies of Alzheimer's disease have gathered a substantial amount of neuroimaging data. New methods ...

Self-calibrated brain network estimation and joint non-convex multi-task learning for identification of early Alzheimer's disease.

Detection of early stages of Alzheimer's disease (AD) (i.e., mild cognitive impairment (MCI)) is important to maximize the chances to delay or prevent...

Ambivert degree identifies crucial brain functional hubs and improves detection of Alzheimer's Disease and Autism Spectrum Disorder.

Functional modules in the human brain support its drive for specialization whereas brain hubs act as focal points for information integration. Brain h...

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment.

Mild cognitive impairment (MCI) is the first sign of dementia among elderly populations and its early detection is crucial in our aging societies. Com...

Adaptive sparse learning using multi-template for neurodegenerative disease diagnosis.

Neurodegenerative diseases are excessively affecting millions of patients, especially elderly people. Early detection and management of these diseases...