Anxiety & Stress

Identification of Chronic Stress-Related Biomarkers for Potential Diagnosis and Treatment of Osteoporosis: An Integrated Multi-omic and Clinical Data Analysis.

OBJECTIVE: The mechanisms through which chronic stress-related genes influence the diagnosis of osteoporosis (OP), where chronic stress serves as a risk factor, remain unclear. This study aimed to identify chronic stress-related biomarkers using multi-omics approaches and explore their potential applications in the diagnosis and treatment of OP. METHODS: Bulk RNA sequencing (bulk RNA-seq) and sing...

Predictors of Detectable Viral Load among Adolescents with HIV in Low Resource Settings who are Receiving Care in Youth-Friendly Clinics.

OBJECTIVE: Adolescents with HIV (AWH) have higher rates of detectable viral loads (DVL) than adults. We sought to identify clinical and psychosocial predictors of DVL among AWH in optimized care environments. METHODS: We prospectively recruited 1,250 AWH (aged 10-19) from four youth-friendly HIV clinics in Eswatini and Lesotho (May 2023-October 2024). Participant clinical data was abstracted from ...

Heat shock protein-mediated remodeling of the bone immune microenvironment: mechanisms and precision therapeutic strategies for osteoporosis.

BACKGROUND: Osteoporosis is a systemic bone disorder marked by reduced bone mass and deteriorating bone microstructure, commonly associated with infla...

Artificial intelligence in traumatic stress treatment: The TRUST framework for ethical development, clinical applications, and research advancement.

Posttraumatic stress disorder (PTSD) and depression are common diagnoses following traumatic events, with several available evidence-based interventio...

Interpretable Machine Learning to Predict Anxiety or Depression in Acute Ischemic Stroke after IV Thrombolysis: A Retrospective Cohort Study.

BACKGROUND: Acute Ischemic Stroke (AIS) represents a prevalent cerebrovascular condition characterized by significant levels of disability and mortali...

Integrating weighted gene co-expression network analysis and machine learning reveal that NDUFA4L2 alleviates KA-induced HT22 cell neurotoxicity, apoptosis, oxidative stress, and mitochondrial dysfunction.

Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, with frequent seizures often leading to cognitive, emotional, and psychiatri...

360° Video-Based Virtual Reality for Preparing Medical Students for Body Donor Dissection: Randomized Controlled Trial.

BACKGROUND: Body donor dissection is fundamental to medical education but often induces anxiety and emotional distress in students, potentially impact...

From stigma to comfort: examining stress and disclosure pathways in gay men's interactions with AI chatbots.

Artificial intelligence (AI) chatbots are increasingly used to provide mental health support, but their effectiveness depends on users' willingness to...

Targeting the IKKα/NF-κB Axis with SGEC-Derived Exosomal miR-23b-3p Rebalances Treg/Th17 Immunity in Sjögren's Syndrome.

BACKGROUND: Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by chronic inflammation, oxidative stress, and progressive salivar...

A large-scale annotated Urdu corpus and deep learning benchmark for mental health classification.

Millions of people worldwide are affected by mental health disorders, particularly anxiety and depression, which pose a growing health concern globall...

State anxiety may mediate the association between striato-cortical circuitry and anxiety symptom severity in generalized anxiety disorder: A resting-state fMRI study and support vector machine analysis.

BACKGROUND: Patients with generalized anxiety disorder (GAD) show structural and functional striatal abnormalities. While state and trait anxiety are ...

Behavioral Inhibition Network Predicts Alcohol Use in Men and Stress in Women.

OBJECTIVE: Impulsivity, a complex construct linked to addictions, is often inconsistently assessed and conceptualized, making it difficult to effectiv...

Career anxiety in the age of artificial intelligence: Survey data of university students in Bangladesh.

Career anxiety has become a significant issue in today's world, particularly in developing countries where job opportunities are scarce compared to th...

Mechanism of liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract in alleviating piglet weaning stress via binding to alpha-1-microglobulin/bikunin precursor by machine learning and molecular dynamics simulation.

Weaning stress is a prevalent pathological condition in pig farming, primarily triggered by factors such as nutritional imbalance, oxidative stress, i...

A Flexible Wireless Passive Platform for Decoupled Electrolyte and Temperature Sensing Toward Heat‑Stress Assessment.

Strenuous exercise and heat exposure can significantly elevate core body temperature and induce profuse sweating, leading to dehydration, electrolyte ...

Predictive modeling of urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG) in metal workers: A comparative study of machine learning algorithms in toxicology.

Urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG), a biomarker for oxidative DNA damage, is commonly used to assess the repair of reactive oxygen species (...

Developing and Testing a Brief Mindfulness Just-in-Time Adaptive Intervention to Reduce Stress Among Caregivers of People With Dementia: Quasi-Experimental Study.

BACKGROUND: Dementia caregiving entails chronic, fluctuating stress with downstream risks to caregivers' mental health and quality of care. Mindfulnes...

GNN-based deep surrogate modeling of knee contact mechanics: generalizing neuromuscular control patterns across subjects.

BACKGROUND: Accumulation of abnormal contact stress is a primary biomechanical driver of acute meniscal tears and chronic osteoarthritis. While Finite...

Machine learning-guided multi-omics suggests iron-dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress.

Root plasticity is crucial for crop survival under climate change. However, the coordinated regulatory network between metabolic disturbances and horm...

DEHP-induced male reproductive toxicity: Evidence from population studies, animal experiments, and multi-omics profiling.

OBJECTIVE: To evaluate the association between di(2-ethylhexyl) phthalate (DEHP) exposure and testosterone deficiency in adult men, and to explore mol...