Anxiety & Stress

Exploring stress and coping among black women in early midlife with elevated blood pressure in a safety-net health system: a qualitative focus group protocol.

INTRODUCTION: Black women in early midlife experience disproportionate exposure to stress and elevated cardiovascular risk, including hypertension. Despite this, few stress management interventions are designed with and for this population. This study aims to explore the lived experiences of stress and coping among black women in early midlife with elevated blood pressure to inform the codesign of...

Hypnosis reshapes multilevel stress response and enhances executive performance in stressed medical students.

Stress and anxiety impair executive function and degrade performance, yet rapid and scalable interventions remain limited. This controlled study tested whether a single personalized hypnosis session could enhance stress regulation and cognitive performance during negative memory recall in medical students. Forty-nine final-year students were assigned to hypnosis or a breath-focused attention condi...

Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine.

Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to imp...

Hydrodynamic modulation of microplastic bioaccumulation in edible fish: Integrating biomarker networks, machine learning, and food safety perspectives.

Microplastic (MP) pollution poses increasing environmental and food safety risks, yet the role of hydrodynamics in MPs bioaccumulation and fish physio...

Predictive machine learning algorithms for depression and anxiety disorders in six cancer types: a comprehensive multi-center population-based study.

OBJECTIVE: Machine learning (ML) has advanced predictive modeling in medical diagnosis and risk assessment through large clinical datasets, yet applic...

Nomogram based on the pre-treatment systemic oxidative stress score to predict the prognosis of surgically treated patients with oral squamous cell carcinoma: competing risk model analysis.

The aim of this study was to explore the prognostic predictive importance of the pre-treatment systemic oxidative stress score (SOS) in surgically tre...

Environmental toxicant exposure and diabetes risk: An exposome-wide association study integrating mixture effects and molecular mechanisms.

Environmental toxicant exposure has emerged as a potential contributor to diabetes, yet systematic investigations integrating multiple chemicals and b...

Rapid response teams for new leaders: a narrative review of global evidence and implementation strategies with a focus on Japan.

BACKGROUND: Rapid response systems (RRSs) are designed to detect and treat physiological deterioration before cardiac arrest occurs. Since 2020, Japan...

Association of allostatic load index with cognitive impairment in high-risk stroke populations.

BACKGROUND: Chronic psychosocial stress induces cumulative physiological dysregulation that accelerates biological aging and contributes to the develo...

Prediction of adolescent internalizing disorder risk: Evidence from the Norwegian mother, father, and child cohort study.

BACKGROUND: Internalizing disorders are among the most common psychiatric conditions in adolescence, often associated with long-term adverse outcomes....

Integrative Molecular Pattern Learning for Mental Disorders Via Dual-Effect Matrix-Enabled Multiomics Platform.

Mental health issues are surging in contemporary society, especially among adolescents and adults, harming well-being and social functioning. Objectiv...

The quantum method of planes-local pressure definitions for machine learning potentials.

Stress, or pressure, is a central quantity in engineering and remains vital in molecular modeling. However, the commonly used virial stress tensor is ...

Task-aware multiple instance learning for stress detection from facial video data.

Stress is a prevalent condition linked to a wide range of mental and physical health disorders. Timely detection of stress is critical for enabling ea...

A Wearable Brain-Computer Interface for Mitigating Car Sickness via Attention Shifting.

Car sickness, an enormous vehicular travel challenge, affects a significant proportion of the population. Pharmacological interventions are limited by...

Co-Designed Mental Health Screening App (Here for You) for University Students: Pilot Feasibility Mixed Methods Study.

BACKGROUND: Mental health disorders are a growing public health concern among university students globally and in India, exacerbated by stigma and lim...

Bio-Inspired Design of Quasi-Ordered Structural Color via Stress-Driven Reconfiguration Enables Ultra-Secure and Scalable Unclonable Application.

Physically unclonable functions (PUFs) offer intrinsic security for next-generation authentication systems, yet current optical PUFs face a trilemma-s...

A Deep Learning Framework for Comprehensive Prediction of Human RNA G-Quadruplex-Binding Proteins.

MOTIVATION: G-quadruplex-binding proteins (G4BPs) play key roles in RNA metabolism and stress response, yet their identification remains experimentall...

Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, bu...

Predicting Adolescent Response to School-Based Mindfulness: A Secondary Analysis of the MYRIAD Trial.

IMPORTANCE: Depression most commonly first emerges during adolescence, making early prevention critical. While school-based mindfulness training (SBMT...

Uncovering the potential mechanisms of aspartame-induced oral leukoplakia via integrated network toxicology and molecular dynamics simulations.

OBJECTIVE: Aspartame, a widely used artificial sweetener, has attracted increasing attention for its potential systemic and oral toxicity. However, th...