Anxiety & Stress

Integrating weighted gene co-expression network analysis and machine learning reveal that NDUFA4L2 alleviates KA-induced HT22 cell neurotoxicity, apoptosis, oxidative stress, and mitochondrial dysfunction.

Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, with frequent seizures often leading to cognitive, emotional, and psychiatric issues. A prominent pathological change associated with TLE is hippocampal sclerosis (HS), characterized by neuronal loss, gliosis, and increased neuron fibre density. However, the pathogenesis of Temporal lobe epilepsy with hippocampal sclerosis (...

360° Video-Based Virtual Reality for Preparing Medical Students for Body Donor Dissection: Randomized Controlled Trial.

BACKGROUND: Body donor dissection is fundamental to medical education but often induces anxiety and emotional distress in students, potentially impacting learning outcomes and well-being. Traditional preparation methods emphasize technical and procedural elements while inadequately addressing students' emotional challenges. Recent advances in educational technology, particularly 360° video-based v...

Digital service innovation for climate-resilient urban pavements: Decision-as-a-service linking UHI-aware ML to environmental-economic performance.

Cities increasingly require digital services that convert urban climate signals into maintenance decisions with measurable environmental and economic ...

From stigma to comfort: examining stress and disclosure pathways in gay men's interactions with AI chatbots.

Artificial intelligence (AI) chatbots are increasingly used to provide mental health support, but their effectiveness depends on users' willingness to...

Targeting the IKKα/NF-κB Axis with SGEC-Derived Exosomal miR-23b-3p Rebalances Treg/Th17 Immunity in Sjögren's Syndrome.

BACKGROUND: Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by chronic inflammation, oxidative stress, and progressive salivar...

A large-scale annotated Urdu corpus and deep learning benchmark for mental health classification.

Millions of people worldwide are affected by mental health disorders, particularly anxiety and depression, which pose a growing health concern globall...

State anxiety may mediate the association between striato-cortical circuitry and anxiety symptom severity in generalized anxiety disorder: A resting-state fMRI study and support vector machine analysis.

BACKGROUND: Patients with generalized anxiety disorder (GAD) show structural and functional striatal abnormalities. While state and trait anxiety are ...

Behavioral Inhibition Network Predicts Alcohol Use in Men and Stress in Women.

OBJECTIVE: Impulsivity, a complex construct linked to addictions, is often inconsistently assessed and conceptualized, making it difficult to effectiv...

Mechanism of liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract in alleviating piglet weaning stress via binding to alpha-1-microglobulin/bikunin precursor by machine learning and molecular dynamics simulation.

Weaning stress is a prevalent pathological condition in pig farming, primarily triggered by factors such as nutritional imbalance, oxidative stress, i...

A Flexible Wireless Passive Platform for Decoupled Electrolyte and Temperature Sensing Toward Heat‑Stress Assessment.

Strenuous exercise and heat exposure can significantly elevate core body temperature and induce profuse sweating, leading to dehydration, electrolyte ...

Predictive modeling of urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG) in metal workers: A comparative study of machine learning algorithms in toxicology.

Urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG), a biomarker for oxidative DNA damage, is commonly used to assess the repair of reactive oxygen species (...

Developing and Testing a Brief Mindfulness Just-in-Time Adaptive Intervention to Reduce Stress Among Caregivers of People With Dementia: Quasi-Experimental Study.

BACKGROUND: Dementia caregiving entails chronic, fluctuating stress with downstream risks to caregivers' mental health and quality of care. Mindfulnes...

GNN-based deep surrogate modeling of knee contact mechanics: generalizing neuromuscular control patterns across subjects.

BACKGROUND: Accumulation of abnormal contact stress is a primary biomechanical driver of acute meniscal tears and chronic osteoarthritis. While Finite...

Machine learning-guided multi-omics suggests iron-dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress.

Root plasticity is crucial for crop survival under climate change. However, the coordinated regulatory network between metabolic disturbances and horm...

DEHP-induced male reproductive toxicity: Evidence from population studies, animal experiments, and multi-omics profiling.

OBJECTIVE: To evaluate the association between di(2-ethylhexyl) phthalate (DEHP) exposure and testosterone deficiency in adult men, and to explore mol...

Current status and determinants of artificial intelligence-related anxiety among healthcare professionals: A cross-sectional survey study.

AIM: The rapid development of artificial intelligence (AI) has triggered various forms of anxiety among healthcare professionals. This study aimed to ...

War-related stress is associated with resting-state functional connectivity of cognitive control and sensory networks in children.

The ability to read fluently relies on a synchronization between cognitive and sensory abilities and their corresponding brain networks. Environmental...

Clinical learning experiences and artificial intelligence-related anxiety among midwifery students: a cross-sectional study.

BACKGROUND: Artificial intelligence (AI) is rapidly transforming healthcare practice and education, requiring students to adapt to technology-supporte...

Diagnostic system for tebuthiuron soil ecotoxicity using morphophysiological indicators of Mucuna pruriens validated by Lactuca sativa.

This study developed an integrated diagnostic system for tebuthiuron-induced soil ecotoxicity based on morphophysiological indicators of Mucuna prurie...

Integrative Network Toxicology and Machine Learning Identify AKR1C3 as a Candidate Functional Target of Cypermethrin in Colorectal Cancer.

The potential contribution of foodborne pesticide residues to colorectal cancer (CRC) remains insufficiently understood. In this study, we integrated ...