Asthma

The Impact of Bronchodilator Therapy on Systolic Heart Failure with Concomitant Mild to Moderate COPD.

In older adults, chronic obstructive pulmonary disease (COPD) is commonly associated with heart failure with reduced ejection fraction (HFrEF), and the high prevalence of this combination suggests that customized treatment is highly necessary in patients with COPD and HFrEF. To investigate whether the treatment of COPD with tiotropium, an anticholinergic bronchodilator, reduces the severity of hea...

Estimating the Causal Impact of Proximity to Gold and Copper Mines on Respiratory Diseases in Chilean Children: An Application of Targeted Maximum Likelihood Estimation.

In a town located in a desert area of Northern Chile, gold and copper open-pit mining is carried out involving explosive processes. These processes are associated with increased dust exposure, which might affect children's respiratory health. Therefore, we aimed to quantify the causal attributable risk of living close to the mines on asthma or allergic rhinoconjunctivitis risk burden in children. ...

Exhaled breath condensate metabolome clusters for endotype discovery in asthma.

BACKGROUND: Asthma is a complex, heterogeneous disorder with similar presenting symptoms but with varying underlying pathologies. Exhaled breath conde...

Development of an Inline Dry Powder Inhaler That Requires Low Air Volume.

BACKGROUND: Inline dry powder inhalers (DPIs) are actuated by an external air source and have distinct advantages for delivering aerosols to infants a...

Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammati...

A machine learning approach to triaging patients with chronic obstructive pulmonary disease.

COPD patients are burdened with a daily risk of acute exacerbation and loss of control, which could be mitigated by effective, on-demand decision supp...

Collaborative targeted learning using regression shrinkage.

Causal inference practitioners are routinely presented with the challenge of model selection and, in particular, reducing the size of the covariate se...

Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway.

OBJECTIVE: To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammato...

Augmented Personalized Health: How Smart Data with IoTs and AI is about to Change Healthcare.

Healthcare as we know it is in the process of going through a massive change - from episodic to continuous, from disease focused to wellness and quali...

Detection of lung cancer in exhaled breath with an electronic nose using support vector machine analysis.

Lung cancer is one of the most common malignancies and has a low 5-year survival rate. There are no cheap, simple and widely available screening metho...

Diagnosing asthma and chronic obstructive pulmonary disease with machine learning.

This study examines the clinical decision support systems in healthcare, in particular about the prevention, diagnosis and treatment of respiratory di...

Fuzzy model to estimate the number of hospitalizations for asthma and pneumonia under the effects of air pollution.

OBJECTIVE: Predict the number of hospitalizations for asthma and pneumonia associated with exposure to air pollutants in the city of São José dos Camp...

Natural Language Processing for Asthma Ascertainment in Different Practice Settings.

BACKGROUND: We developed and validated NLP-PAC, a natural language processing (NLP) algorithm based on predetermined asthma criteria (PAC) for asthma ...

Early Detection of Peak Demand Days of Chronic Respiratory Diseases Emergency Department Visits Using Artificial Neural Networks.

Chronic respiratory diseases, mainly asthma and chronic obstructive pulmonary disease (COPD), affect the lives of people by limiting their activities ...

High-accuracy detection of airway obstruction in asthma using machine learning algorithms and forced oscillation measurements.

BACKGROUND AND OBJECTIVES: The main pathologic feature of asthma is episodic airway obstruction. This is usually detected by spirometry and body pleth...

Cross-Disciplinary Consultancy to Enhance Predictions of Asthma Exacerbation Risk in Boston.

This paper continues an initiative conducted by the International Society for Disease Surveillance with funding from the Defense Threat Reduction Agen...

Medicinal Plants of the Australian Aboriginal Dharawal People Exhibiting Anti-Inflammatory Activity.

Chronic inflammation contributes to multiple ageing-related musculoskeletal and neurodegenerative diseases, cardiovascular diseases, asthma, rheumatoi...

Laparoendoscopic Rendezvous for Concomitant Cholecystocholedocholithiasis: A Successful Modality Even in the Most Difficult Presentations Including Pregnancy.

. Laparoendoscopic rendezvous (LERV) technique is emerging as an attractive treatment option for concomitant cholecystocholedocholithiasis. In this pa...

Classification of Exacerbation Frequency in the COPDGene Cohort Using Deep Learning With Deep Belief Networks.

This study aims to develop an automatic classifier based on deep learning for exacerbation frequency in patients with chronic obstructive pulmonary di...

Analysis of correlation between pediatric asthma exacerbation and exposure to pollutant mixtures with association rule mining.

OBJECTIVES: Traditional studies on effects of outdoor pollution on asthma have been criticized for questionable statistical validity and inefficacy in...