Asthma

Carbon quantum dots exacerbate Parkinson's disease-like pathology through microglia-mediated neuroinflammatory responses with toxicological implications.

The global burden of Parkinson's disease (PD) is projected to double by 2050, with early-onset cases demonstrating accelerated progression and limited therapeutic options. Recently, carbon quantum dots (CQDs) emerge as promising nanoplatforms for PD theragnostic, but their paradoxical role in exacerbating neuroinflammation and neurodegeneration shows the urgent need for mechanistic safety evaluati...

Integrating Clinical Modeling and Machine Learning for Risk Assessment of Paracetamol and Other Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children.

BACKGROUND: Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity is a common cause of drug-related reactions in children. Pre-test risk stratification may improve the safety and efficiency of drug provocation testing (DPT). OBJECTIVE: To develop a clinically interpretable risk stratification tool (nomogram+simplified score) for pediatric paracetamol and/or other NSAID hypersensitivity and ...

Recent insights for fish allergens: novel processing techniques and detection technology.

Fish allergy is a common food-related allergic reaction that can lead to serious health issues and poses a significant challenge to global food safety...

AI based prediction of severe exacerbation in Asian bronchiectasis patients using the KMBARC registry.

Transcriptome Profiling of Peripheral Blood for Inflammatory Subtype Classification and Diagnostic Model Construction in Asthma.

OBJECTIVE: This study aimed to identify inflammatory subtypes of asthma using peripheral blood transcriptomics and to derive candidate biomarkers supp...

From guidelines to algorithms: the future of AI-augmented asthma care.

PURPOSE OF REVIEW: Artificial intelligence (AI) has emerged as an increasingly accessible and influential resource within both public and clinical dom...

Non-pharmacological treatment of AECOPD.

Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are acute events characterized by rapid worsening of dyspnea, cough, and sputum...

The rise of artificial intelligence in respiratory primary care and pulmonology: a scoping review.

Artificial intelligence (AI) is rapidly advancing respiratory disease management, from diagnosis to population lung health. This scoping review synthe...

A review of ageing related biomarkers in breath.

The growing ageing population presents significant challenges for healthcare systems, particularly in monitoring age-related physiological decline. Ag...

Identifying microbial protease allergens through protein language model-guided homology.

Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study le...

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC).

BACKGROUND: Current relevance of positive patch-test reactions guides management in allergic contact dermatitis (ACD), yet its clinical predictors and...

Insight into the oxidation mechanism of low-salt Sichuan-style sausages treated with inclusion complexes of tea-polyphenol/β-cyclodextrin/NaCl and electron beam irradiation using machine learning algorithms.

Low-salt sausages are gaining popularity due to health risks from high salt intake. In this study, the effects of electron beam irradiation (EBI) at v...

Classification, performance and recycling of ceria-based materials used for chemical mechanical polishing.

Ceria (CeO2)-based materials, endowed with balanced chemical reactivity and moderate mechanical hardness, are extensively applied in ultra-precision s...

Integrating qHTS and QSAR Models to Identify Safe GPCR-Targeted Compounds: A Focus on hERG-Dependent Cardiotoxicity.

G-protein-coupled receptors (GPCRs) are a diverse family of seven-transmembrane domain receptors that play pivotal roles in various physiological and ...

Ferroptosis-Related Signature Genes and Immune Landscape in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

UNLABELLED: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by heightened inflammation and immune dysregulation,...

Fuzzy logic in respiratory medicine: a systematic review of predictive and diagnostic applications.

BACKGROUND: There is increasing interest in the use of artificial intelligence (AI) to assist with respiratory diagnosis and risk prediction. Fuzzy lo...

Molecular docking approaches in mycetoma: Toward improved patient management.

Mycetoma is a neglected tropical disease characterised by chronic, granulomatous inflammation of the subcutaneous tissues, often leading to disfigurem...

Evaluation of large Language models on pediatric asthma: a comparative study of Claude3-Opus, Gemini 2.0, ChatGPT-4o, and DeepSeek-a cross-sectional questionnaire study.

Inhibition of the p38/JNK MAPK pathway mediated by circadian rhythm genes: Study of the mechanism of Linggan Wuwei Jiangxin decoction in the treatment of COPD.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a frequently encountered respiratory disease. Its clinical symptoms ar...

A dataset collected in real-world industrial control systems for network attack detection.

In the context of Industry 4.0, Industrial Control Systems (ICSs) are undergoing a significant transition from physical isolation to partial openness....