Atherosclerosis

Drug repurposing to identify potential FDA-approved drugs targeting three main angiogenesis receptors through a deep learning framework.

Tumor cell survival depends on the presence of oxygen and nutrients provided by existing blood vesse...

The Emerging Role of Computed Tomography Coronary Angiography in the Left Main Stem Percutaneous Coronary Intervention.

Recent advancements in computed tomography have significantly transformed the clinical application o...

Artificial intelligence-derived coronary plaque features predict incident acute ischaemic stroke independent of cardioembolic risk factors.

Integrative Machine Learning Approach to Explore Glycosylation Signatures and Immune Landscape in Moyamoya Disease.

Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder of uncertain etiology. Although a...

A Joint Geometric Topological Analysis Network (JGTA-Net) for Detecting and Segmenting Intracranial Aneurysms.

OBJECTIVE: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage. Detecting intracr...

Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.

Alzheimer's disease (AD) and atherosclerosis (AS) are two interacting diseases mostly affecting aged...

Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm.

BACKGROUND: Abdominal aortic aneurysm (AAA), characterized by the pathological dilation of the abdom...

Intercellular communication in the brain via dendritic nanotubular network.

Recent studies have identified intercellular networks for material exchange by bridge-like nanotubul...

Associations of the Hs-CRP/HDL-C ratio with stroke among US adults: Evidence from NHANES 2015-2018.

BACKGROUND: The high-sensitivity C-reactive protein (Hs-CRP)-to-high-density lipoprotein cholesterol...

Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex mol...

Contemporary Prevention and Management of Postoperative Delirium in Cardiac Surgery Patients.

This review examines the prevention and management of postoperative delirium in cardiac surgery pati...

Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.

Alzheimer's disease (AD), the most common form of dementia, is marked by cognitive decline and amylo...

Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases.

This study developed a new Cellular Omics-Structural Integration (COSI) technology platform to addre...

Cardiovascular imaging in 2024: review of current research and innovations.

Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, ...

Fluid fluctuations assessed with artificial intelligence during the maintenance phase impact anti-vascular endothelial growth factor visual outcomes in a multicentre, routine clinical care national age-related macular degeneration database.

AIM: To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in ...

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer's Disease.

Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and int...

Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.

Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capill...

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains cru...

Multi-centric AI Model for Unruptured Intracranial Aneurysm Detection and Volumetric Segmentation in 3D TOF-MRI.

The aim of this study was to develop an open-source nnU-Net-based AI model for combined detection an...

Switching Therapy to the Second Brand of Generic Atorvastatin: A 6-Month Retrospective Cohort, Real-World Study.

INTRODUCTION: High levels of low-density lipoprotein-cholesterol (LDL) is a major risk factor for ca...

An All-in-one Nanohole Array for Size-Exclusive Trapping and High-Throughput Digital Counting of Single Extracellular Vesicles for Non-invasive Cancer Screening.

The analysis of single small extracellular vesicles (sEVs) could distinguish the heterogeneity of sE...