Atherosclerosis

High burden of premature ventricular contractions upregulates transcriptional markers of inflammation and promotes adverse cardiac remodeling linked to cardiomyopathy.

Premature ventricular contractions (PVCs) are the most prevalent ventricular arrhythmia in adults. H...

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-Fluorescence Imaging.

Advances in organoid models, as ex vivo mini-organs, and the development of screening imaging techno...

The Emerging Role of Computed Tomography Coronary Angiography in the Left Main Stem Percutaneous Coronary Intervention.

Recent advancements in computed tomography have significantly transformed the clinical application o...

Artificial intelligence-derived coronary plaque features predict incident acute ischaemic stroke independent of cardioembolic risk factors.

Integrative Machine Learning Approach to Explore Glycosylation Signatures and Immune Landscape in Moyamoya Disease.

Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder of uncertain etiology. Although a...

A Joint Geometric Topological Analysis Network (JGTA-Net) for Detecting and Segmenting Intracranial Aneurysms.

OBJECTIVE: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage. Detecting intracr...

Aging at the Crossroads of Organ Interactions: Implications for the Heart.

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes....

Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.

Alzheimer's disease (AD) and atherosclerosis (AS) are two interacting diseases mostly affecting aged...

Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm.

BACKGROUND: Abdominal aortic aneurysm (AAA), characterized by the pathological dilation of the abdom...

Intercellular communication in the brain via dendritic nanotubular network.

Recent studies have identified intercellular networks for material exchange by bridge-like nanotubul...

Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.

BACKGROUND AND OBJECTIVE: Atherogenicity indices have emerged as promising markers for cardiometabol...

Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex mol...

Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases.

This study developed a new Cellular Omics-Structural Integration (COSI) technology platform to addre...

Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.

Alzheimer's disease (AD), the most common form of dementia, is marked by cognitive decline and amylo...

Contemporary Prevention and Management of Postoperative Delirium in Cardiac Surgery Patients.

This review examines the prevention and management of postoperative delirium in cardiac surgery pati...

Cardiovascular imaging in 2024: review of current research and innovations.

Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, ...

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer's Disease.

Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and int...

Fluid fluctuations assessed with artificial intelligence during the maintenance phase impact anti-vascular endothelial growth factor visual outcomes in a multicentre, routine clinical care national age-related macular degeneration database.

AIM: To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in ...

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains cru...

Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.

Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capill...

Circulating fibroblast growth factor 21 is associated with blood pressure in the Chinese population: a community-based study.

BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating...