Autism

Single-cell approach dissecting agr quorum sensing dynamics in Staphylococcus aureus.

Quorum sensing (QS) enables bacteria to coordinate collective behaviors by secreting and sensing diffusible signals. Understanding QS at single-cell resolution is essential because population-level measurements often obscure regulatory heterogeneity. In Staphylococcus aureus, the accessory gene regulator (agr) system is a major QS-controlled virulence regulator activated by autoinducing peptides (...

Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants.

Pemphigus vulgaris (PV) is a rare autoimmune blistering disease mediated by pathogenic autoantibodies. Although both HLA and non-HLA loci contribute to disease susceptibility, their combined roles in immune regulation remain incompletely understood. This study investigated the joint contribution of HLA-DRB1 and FCGR2B variants to PV susceptibility within an integrative immunogenetic framework. Gen...

Novel biomarkers driving treatment selection in metastatic castration-sensitive prostate cancer: fundamentals of personalized clinical decision making.

INTRODUCTION: Prostate cancer is well known to be androgen-dependent, with growth directly relying on the androgen receptor signaling pathway. In fact...

Rapid Cas13a-based penA genotyping for cefixime susceptibility in Neisseria gonorrhoeae.

UNLABELLED: Antimicrobial resistance in Neisseria gonorrhoeae is an urgent public health threat. Resistance-guided therapy can assure appropriate trea...

ProSSF: integrating sequence, structure, and gene ontology for prediction of protein stability, interaction, and function.

Protein sequences encode rich structural and functional information that governs how organisms respond to genetic variation, environmental challenge, ...

Generative artificial intelligence in animal genomics for smart agriculture: Applications, challenges, and future prospects.

Generative artificial intelligence (AI) is becoming a groundbreaking paradigm in the field of animal genomics and is providing the possibility to take...

Peptides as integrative modulators for clinical prognosis and targeted therapy in pancreatic cancer.

Pancreatic cancer remains a formidable global health challenge, ranking as the twelfth most common malignancy yet claiming an outsized toll with disma...

Unraveling Atherosclerosis through Multi-omics: Systematic Insights into the Unique Applications and Clinical Perspectives.

PURPOSE OF REVIEW: Atherosclerosis (AS) is a progressive disease of the arterial wall characterized by metabolic dysregulation, inflammatory activatio...

A contrastive reconstruction vision transformer model for intelligent diagnosis of autism spectrum disorder.

Automated assessment through the analysis of facial expressions in autism can assist in early screening, providing strong support for timely intervent...

Spatio-temporal reconstruction of early brain developmental trajectories via self-supervised learning.

Charting the normative and atypical trajectories of the brain's rapid early-life reorganization is crucial for understanding neurodevelopment. Althoug...

GATA Family Transcription Factor OsGATA1 Regulates Grain Size and Brassinosteroid Biosynthesis in Rice.

Grain size is a critical agronomic trait that influences grain yield in rice. However, the molecular mechanisms underlying grain size regulation in ri...

Enhancing Drug Response Prediction in Epilepsy with Emerging Multimodal Models: Focus on Clinical, Pharmacologic, and Genomic Factors.

Epilepsy is a common neurological disorder, with approximately one-third of the affected population developing drug-resistant epilepsy despite the exp...

Classification of autism spectrum disorder using a directional graph attention network on brain effective connectivity.

Recent research into the neural mechanisms underlying autism spectrum increasingly relies on brain network analysis; however, conventional models rema...

Optimized quadrangle attention consolidated convolutional multi-scale vision transformer based autism detection.

Autism is a complex neurological condition characterized by repetitive behaviours, varied speech and difficulties in social interaction. Identifying a...

Structure-aware retinal disentanglement reveals the genetic architecture of ocular and systemic diseases.

Deep learning effectively extracts retinal phenotypes but often functions as an entangled black box, obscuring specific genetic mechanisms and hinderi...

Machine learning-guided risk stratification for Long QT Syndrome genetic variants with hiPSC-derived cardiomyocytes.

AIMS: Long QT syndrome (LQTS) is a life-threatening genetic disorder characterized by prolonged QT intervals on electrocardiograms. Congenital forms a...

Magnetic medical microrobots with memory-capable genetic circuits.

Autonomous microrobots can reach hard-to-access regions in the human body for minimally invasive therapy. However, their microscale size limits the in...

Maternal genetic variants associated with aneuploid conception: a narrative review.

BACKGROUND: Human aneuploid conception, a leading cause of infertility, pregnancy loss, and congenital disorders (e.g. Down's syndrome), arises from e...

BrainPrompt+: Multi-Level Brain Prompt Learning for Knowledge-Guided Neurological Disorder Identification.

Accurate identification of neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and Autism Spectrum Disorder (ASD) is ch...

Quality of Autism Information Generated by Artificial Intelligence Tools: Implications for Paediatric Care.

AIM: Families increasingly turn to artificial intelligence (AI) tools for information about autism spectrum disorder (ASD), often during early childho...