Neurology

Autism

Latest AI and machine learning research in autism for healthcare professionals.

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The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study and Literature Review.

BACKGROUND AND OBJECTIVES: Frontotemporal lobar degeneration TDP43 type C (TDP-C) is a rare and unique neurodegenerative disease that attacks the anterior temporal lobe. Recently, it was shown that Annexin-A11 and TDP-43 coaggregate specifically in TDP-C. Current literature on the genetic associations with TDP-C, reviewed here, lacks a discernible corpus of robust or replicated findings. In this s...

Mar 23 2026 41883703

Predicting early clinical recovery in first-episode psychosis: development and external validation of a clinically interpretable multivariable model.

BACKGROUND: Identifying patients with first-episode psychosis (FEP) who are unlikely to achieve early clinical recovery (ECR) is critical for personalised intervention and resource allocation. ECR - defined as the concurrent achievement of symptomatic and functional remission - represents a clinically meaningful outcome that captures both illness control and functional reintegration. AIMS: To deve...

Mar 23 2026 41867014
REM Sleep Abnormalities in Children With Autism Spectrum Disorder.

Sleep disturbances are common in children with autism spectrum disorder (ASD). However, the sleep pattern changes including rapid eye movement (REM) s...

Mar 23 2026 41869731
In silico discovery of selective TPX2 and BUB1B inhibitors as novel antimitotic agents in breast cancer therapy.

Breast cancer (BC) is one of the most common malignancies in women globally, characterized by significant genetic and clinical heterogeneity. This com...

Mar 22 2026 41895167
Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders.

Disorders of the central nervous system (CNS), neurological disorders, neurodegenerative disorders, genetic disorders) constitute a significant burden...

Mar 21 2026 41865126
Temporal dynamics of mercury exposure and associated health and economic burdens in China.

Mercury is a global highly toxic pollutant linked to neurodevelopmental impairments and cardiovascular risks. However, despite being the world's large...

Mar 20 2026 41863947
HOW GENETICS CHANGED OR WILL CHANGE THE THERAPY IN THYROID NODULES WITH INDETERMINATE CYTOLOGY.

The incidence of thyroid cancer has risen in recent decades, largely due to the widespread use of increasingly sensitive imaging techniques that have ...

Mar 20 2026 41866067
Longitudinal Investigation of Postural Strategies Associated with Improvement in Gait Speed Following Adult Spinal Deformity Surgery using Machine Learning.

STUDY DESIGN: Retrospective longitudinal cohort study. OBJECTIVE: To identify postural strategies associated with improvement in gait speed following ...

Mar 20 2026 41860195
FedGA: Genetic Algorithm-Guided Federated Learning for Medical Image Segmentation with Non-IID Features.

Federated learning (FL) enhances data privacy and compliance with data regulations by enabling multiple decentralized parties to collaboratively train...

Mar 20 2026 41860918
Atypical Ductular Reactions Are a Distinct Regenerative Phenomenon in Hepatocellular Carcinoma (HCC) Patients after Transarterial Chemoembolization.

Transarterial chemoembolization (TACE) is increasingly used in patients with hepatocellular carcinoma (HCC), the most frequent primary liver tumor. At...

Mar 19 2026 41864479
Bulliform cells: anatomical, physiological, genetic, and computational perspectives on plants' drought adaptation.

This work highlights pollen thermotolerance as vital for reproductive success under heat stress, integrating molecular regulation, gene mapping, and b...

Mar 19 2026 41857245
Predicting self-image satisfaction after adult spinal deformity surgery: a machine learning approach using patient phenotypes.

PURPOSE: To characterize the evolution of the Self-Image (SI) domain of the Scoliosis Research Society-22 item questionnaire (SRS-22) in adult spinal ...

Mar 19 2026 41855022
Hyperspectral phenotyping reveals the genetic basis of grain quality in rice.

Rice (Oryza sativa) grain quality is an important breeding target, yet its genetic basis remains incompletely understood. In this study, we integrated...

Mar 18 2026 42003996
An early detection framework for young Chinese learners at risk of reading difficulty using fNIRS and deep learning.

Reading difficulty (RD), a neurodevelopmental disorder affecting language acquisition in children, necessitates early screening for effective educatio...

Mar 18 2026 41851364
A framework of hybrid deep learning and nature-inspired algorithms for accurate multi-class fundus disease classification.

Fundus imaging is an essential technique for detecting anatomical changes indicative of various ophthalmological diseases. These alterations-including...

Mar 17 2026 41850601
Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.

Across the animal kingdom, social behaviors such as aggression are critical for survival and reproductive success. While there is significant variatio...

Mar 17 2026 41845924
Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL): Protocol for a Prospective Observational Cohort Study.

BACKGROUND: Understanding interindividual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymph...

Mar 17 2026 41843828
Generative design of synthetic gene circuits for functional and evolutionary properties.

In the past decades, a wide suite of design tools for biological systems has been developed, but using these to create biotechnologies that achieve re...

Mar 16 2026 41839899
The impact of stability considerations on genetic fine-mapping.

Fine-mapping methods, which aim to identify genetic variants responsible for complex traits following genetic association studies, typically assume th...

Mar 16 2026 41838038
Radiomics in fetal brain MRI: a narrative review.

Fetal MRI has emerged as a crucial supplement to prenatal ultrasonography in the evaluation of the developing brain and in identifying congenital defe...

Mar 16 2026 41838340
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