Autism

Deep learning reveals the complex genetic architecture of male guppy colouration.

The extraordinary variation in male guppy (Poecilia reticulata) colouration is a powerful model for studying the interplay of natural and sexual selection. However, the complexity of this variation has hampered the high-resolution characterization and determination of the genetic architecture underlying male guppy colour and clouded our understanding of how this exceptional level of diversity is m...

Can mutation abundance assess the biological behavior of BRAF-positive papillary thyroid carcinoma?

BACKGROUND: BRAF mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether BRAF mutation status and abundance are related to PTC biological behavior and whether BRAF mutation abundance can be used to further stratify ri...

[Artificial intelligence in preventive medicine for children and adolescents-applications and acceptance].

The use of artificial intelligence (AI) in pediatric and adolescent medicine offers numerous possibilities, particularly in the prevention of chronic ...

MRI's evolving role in rectal cancer in the era of personalized medicine.

Recent decades have seen great advances in the diagnosis and management of rectal cancer, and magnetic resonance imaging (MRI) has become pivotal for ...

CoSpred: Machine Learning Workflow to Predict Tandem Mass Spectrum in Proteomics.

In mass spectrometry-based proteomics, the use of deep learning algorithms can help improve the identification rates of peptides and proteins through ...

Environmental Drivers of Genetic Divergence in Two Corals From the Florida Keys.

Increasingly frequent marine heatwaves devastate coral reefs around the world, so there is great interest in finding warm-adapted coral populations th...

Perivascular Space Burden in Children With Autism Spectrum Disorder Correlates With Neurodevelopmental Severity.

BACKGROUND: Cerebral perivascular spaces (PVS) are involved in cerebrospinal fluid (CSF) circulation and clearance of metabolic waste in adult humans....

Genetic Deconvolution of Embryonic and Maternal Cell-Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning.

Noninvasive preimplantation genetic testing for aneuploidy based on embryonic cell-free DNA (cfDNA) released in spent embryo culture media (SECM) has ...

An Exploration of the Link Between Genes and Nutrition and How They Affect Food Behavior and Choice.

There are myriad factors that influence our eating habits and behaviors. Some of these factors are due to our genetic predisposition while others are ...

Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.

Neurons in the brain are known to encode diverse information through their spiking activity, primarily reflecting external stimuli and internal states...

Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes.

We have developed a method for generating human telencephalic organoids from stem cell-derived isolated single neural rosettes. The use of single neur...

BrainCHEF: Cross-Level Hypergraph Enhanced Fusion model for brain networks.

Modeling the dynamic characteristics of functional brain networks is of great significance for uncovering the mechanisms of brain function. Although g...

Prognosis and prognostic factors for chronic fibrosing idiopathic interstitial pneumonias.

Progressive lung fibrosis is frequently observed in patients with idiopathic interstitial pneumonias (IIPs), especially in those with idiopathic pulmo...

MVT-Net: A novel cervical tumour segmentation using multi-view feature transfer learning.

Cervical cancer is one of the most aggressive malignant tumours of the reproductive system, posing a significant global threat to women's health. Accu...

Born to Fear the Machine? Genetic and Environmental Influences on Negative Attitudes toward AI Agents.

Despite the rapid development of artificial intelligence (AI) agents, substantial individual differences in public acceptance persist. To explain the ...

Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.

BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a dis...

Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method.

BACKGROUND: Genome-wide association studies have provided profound insights into the genetic aetiology of metabolic syndrome (MetS). However, there is...

Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits.

Electronic health records, biobanks, and wearable biosensors enable the collection of multiple health modalities from many individuals. Access to mult...

A New Insight in Cellular and Molecular Signaling Regulation for Neural Differentiation Program.

Numerous neurological conditions impact the brain, spinal cord, and nerves, including neurodegenerative diseases such as Alzheimer's and Parkinson's d...

Integrating AI and genomics: predictive CNN models for schizophrenia phenotypes.

This study explores the use of deep learning to analyze genetic data and predict phenotypic traits associated with schizophrenia, a complex psychiatri...