Autism

Persistent sheaf Laplacian analysis of protein stability and solubility changes upon mutation.

Genetic mutations frequently disrupt protein structure, stability, and solubility, acting as primary drivers for a wide spectrum of diseases. Despite the critical importance of these molecular alterations, existing computational models often lack interpretability and fail to integrate essential physicochemical interactions. To overcome these limitations, we propose SheafLapNet, a predictive framew...

Multiancestry and Multitrait GWAS Meta-Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases.

Schizophrenia (SCZ) is a highly heritable psychiatric disorder, yet its genetic links with chronic pulmonary diseases remain poorly defined. Such links may reflect shared biological pathways and could create opportunities for cross-disorder risk prediction and therapeutic repurposing. Here we applied a multiancestry, multitrait GWAS framework to SCZ and chronic pulmonary disease datasets. The anal...

DHCA-Net: A Novel Dual-Stream Hierarchical Channel Attention Network for Explainable Autism Spectrum Disorder Detection From Facial Images.

Autism spectrum disorder (ASD) consists of a spectrum of neurodevelopmental conditions characterized by complex behavioural traits and subtle, atypica...

Early digital selection: machine learning and XAI approaches for predicting six-month body weight in hair goats.

Early identification of animals with high growth potential is essential for enhancing efficiency and sustainability in goat breeding systems. This stu...

From Data to Early Diagnosis: Artificial Intelligence as a Tool to Support Screening and Detection of Autism Spectrum Disorder in Childhood.

PURPOSE OF REVIEW: Autism spectrum disorder (ASD) is a neurodevelopmental condition with significant implications for childhood development and public...

Infrared Spectroscopy for Determining Bone Graft Healing and Readiness in Tissue Models.

OBJECTIVE: Successful dental implant placement relies on the proper integration of bone graft material into an area of deficient native bone. Traditio...

Interferon-Associated Antiviral Programs Define LAG-3+ Exhaustion-Like CD8+ T-Cell Remodeling in Influenza a Virus Infection: An Integrative Single-Cell and Multi-Cohort Analysis.

BACKGROUND: Influenza A virus (IAV) infection induces complex antiviral immune responses, yet how innate sensing, host genetic susceptibility, and ada...

Integrating Multimodal Data and Genomics for a Comprehensive Assessment of Cardiovascular Aging and Its Impact.

BACKGROUND: Age-related structural and functional remodeling of the heart and vessels increases cardiovascular disease (CVD) risk, yet comprehensive a...

Prediction models for highly scalable technology-assisted differential diagnostics of autism spectrum disorder.

BACKGROUND: Diagnosing autism spectrum disorder (ASD) in adulthood is time-consuming and markedly complicated by the requirement to distinguish betwee...

A Systematic Review and Quality Appraisal of AI-Augmented Intervention Studies for Autistic Individuals.

Artificial intelligence (AI) has been increasingly integrated into autism interventions to support personalization and scalability; however, the stren...

Mortality risk estimation for autistic older adults: comparing novel machine-learning derived weights versus standard weights for the Charlson Comorbidity Index.

Aim: We aimed to compare Quan and colleagues (2011) established weights for the Charlson Comorbidity Index (CCI) conditions to autism-specific weights...

Silkworm synthetic biology: Toolkit development, chassis engineering, and biomanufacturing applications.

The silkworm, Bombyx mori, is not only an economically important insect but also an increasingly promising chassis for insect synthetic biology. This ...

The neuroscience of childhood brain cancers.

Nervous system activity drives both normal neurodevelopment and childhood brain cancers through paracrine and synaptic signaling. In childhood gliomas...

Genomic, epigenomic and transcriptomic regulation of cellular senescence.

Cellular senescence is a complex, highly regulated cell state induced by cellular damage and stress. Senescence is central to many areas of biology, w...

Artificial intelligence in pediatric medical genetics and genomics.

PURPOSE OF REVIEW: Artificial intelligence (AI) is being rapidly but unevenly integrated into many aspects of medicine as well as society more broadly...

Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing.

CNS-related conditions span tumors, vascular, neurodevelopmental, and psychiatric disorders, yet therapeutic development for CNS disorders continues t...

HFG-Net: High-frequency guided multi-view graph convolution and dynamic spatio-temporal fusion for ASD diagnosis.

Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental condition characterized by significant inter-subject variability in electr...

Non-transgenic rodent models associated with Alzheimer's disease: applications, evaluation, and perspectives.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Familial AD accounts for less than 1% of cases, while sporadic AD (SAD) accounts...

Health databases and early identification of autism spectrum disorder: a scoping review.

OBJECTIVES: To map the available evidence on the use of health databases for the early identification of autism spectrum disorder (ASD) across diverse...

Rapid glycomic analysis of serum EVs reveals altered N-glycosylation patterns in ASD.

Objective laboratory diagnostics for autism spectrum disorder (ASD) are lacking, necessitating rapid clinical screening tools. Because serum extracell...