Infectious Disease

Bacterial Infection

Latest AI and machine learning research in bacterial infection for healthcare professionals.

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Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

Evolution shapes the structure and content of genomes, yet the contribution of local sequence compos...

DeepHalo: Deep Learning-Powered Exploration of Halogenated Metabolites Uncovering Antibacterial Depsipeptides

In the omics era, confident high-throughput analytical tools are crucial for the efficient identific...

Multivariate pattern analysis reveals resting-state EEG biomarkers in fibromyalgia

Fibromyalgia (FM) involves widespread musculoskeletal pain and hypersensitivity, often accompanied b...

CpGPT: a Foundation Model for DNA Methylation

DNA methylation is a type of epigenetic modification that plays a significant role in development, a...

Identifying pyrogenic contaminants using transcriptomic profiling of monocyte activation test with machine learning

The monocyte activation test is an in vitro pyrogenicity assessment method that can utilise human pe...

Tripleknock: predicting lethal effect of three-gene knockout in bacteria by deep learning

Investigating the lethal effect of multi-gene knockout is essential for discovering novel antibiotic...

Generanno: A Genomic Foundation Model for Metagenomic Annotation

The rapid growth of genomic and metagenomic data has underscored the pressing need for advanced comp...

SKOOTS: Skeleton-oriented object segmentation for mitochondria

Segmenting individual instances of mitochondria from imaging datasets can provide rich quantitative ...

A Computational Pipeline for Physiologically Informed Calibration of Ligand Reaction-Diffusion Models Using High-Throughput Sequencing

All physiological processes fundamentally rely on continuous cellular cross-talk to maintain organiz...

Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes

Variation within the prokaryotic pangenome is not random, and natural selection that favours particu...

PAM adenine methylation and flanking sequence regulate SaCas9 activity in bacteria

Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to re...

The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli

The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteri...

Intra-genomic genes-to-genes correlation enables bacterial genome representation

The bacterial pan-genome consists of core genes shared by all members of a taxonomy and accessory ge...

ppIRIS: deep learning for proteome-wide prediction of bacterial protein-protein interactions

Protein–protein interactions (PPIs) are central to cellular processes and host–pathogen dynamics, ye...

Scalable and interpretable secretion system annotation with Sismis

Secretion systems play critical roles in bacterial growth, survival, and pathogenesis. Genes encodin...

PhageAI: a new approach to predicting the lifestyle of bacteriophages using proteinBERT and convolutional neural networks

Bacteriophages are viruses that infect bacteria, including temperate, virulent and chronic phages. I...

Species-agnostic and Salmonella-specific Models for Antimicrobial Resistance Prediction Using FCGR and ResNet-18

Antimicrobial resistance (AMR) prediction from bacterial genomes remains a major challenge for clini...

BIOTIA-DX RESISTANCE Achieved the Best Antimicrobial Resistance Phenotype Prediction Accuracy at CAMDA 2025

We have developed BIOTIA-DX RESISTANCE (BDXR), a bioinformatic tool for predicting antimicrobial res...

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