Bacterial Infection

Smartphone-based multispectral autofluorescence analysis of bacteria mixtures of staphylococci using convolutional neural network.

Improved screening for pulmonary Kaposi sarcoma in a low-resource setting.

OBJECTIVE: The lung is commonly involved in advanced Kaposi sarcoma (KS) but diagnosis of pulmonary KS in low-resource settings is difficult. Clinical assessments were evaluated to improve screening for pulmonary KS in a low-resource setting. METHODS: A longitudinal cohort of Africans with HIV-associated KS in the Parirenyatwa Hospital KS clinic, Harare, Zimbabwe, was followed from 2016 to 2018. A...

SERS technology helps bacterial inactivation in vivo: including detection, identification, and evaluation.

The problem of bacterial infection and antimicrobial resistance has become a major challenge threatening to human health. Detection, identification, a...

Engineered Supramolecular Therapeutics in Development for Combating Antibiotic-Resistant Bacterial Infections.

The emergence of antibiotic-resistant bacteria has rendered conventional antibiotic treatments ineffective, necessitating the development of antibacte...

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.

Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer's disease (AD), but its role in retinal pathology and disease progression i...

Machine learning reveals ecological thresholds and predicts future bacterial community shifts in a chronically eutrophic estuary.

Effectively managing eutrophic estuaries under climate change requires a quantitative understanding of how microbial communities respond to multiple e...

Targeted SERS Nanoparticle Accumulation on Bacteria Enables On-Site Accurate Vibrio Typing in 10 min with AI-Powered SERS.

Vibrio infections progress rapidly with high mortality, yet current diagnostics fail to meet the critical need for rapid, accurate, and field-deployab...

Vancomycin resistance in gram-positive infections: evolutionary strategies of survival.

Vancomycin is a critical glycopeptide antibiotic for treating severe infections caused by Gram-positive bacteria, particularly MRSA and Clostridioides...

Elucidating the link between NS-SNP-Induced protein conformational changes and drug resistance in Klebsiella pneumoniae.

The escalating drug-resistance of Klebsiella pneumoniae (K. pneumoniae), a leading cause of both community-acquired and nosocomial infections, poses a...

Classification and detection of Salmonella, Escherichia coli O157:H7, and Listeria monocytogenes using Fourier-transform near infrared spectroscopy coupled with machine learning.

This study was conducted to investigate the potential use of Fourier-transform near-infrared (FT-NIR) spectroscopy combined with machine learning (ML)...

Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history.

The transition from anaerobic to aerobic life was a pivotal adaptation in Earth's history, yet the timing and genomic drivers remain poorly resolved. ...

One-Step Design of Potent and Nonhemolytic Antimicrobial Peptides by Using a Database-Guided, Nonmachine Learning Approach.

The search for antibiotics is urgent because of the global antibiotic resistance problem. While a variety of strategies are actively sought, interest ...

Establishment of threshold of human gut microbes and risk assessment system for colorectal cancer.

BACKGROUND: Being involved in the occurrence of colorectal cancer (CRC), gut microbes are potential targets for early diagnosis of CRC. Defining the t...

Whole-genome sequencing and comparative genomics reveal antimicrobial potential and adaptive traits of Bacillus velezensis AM12.

The global rise of antimicrobial resistance has intensified the demand for novel antimicrobial agents with broad-spectrum efficacy and unique mechanis...

A novel hypothetical protein (SAUSA300_1684) confers excellent protection against multi-drug-resistant Staphylococcus aureus infection in the murine model.

Staphylococcus aureus is a leading cause of nosocomial infections, including sepsis, bacteraemia, pneumonia, and endocarditis, and continues to pose a...

Deconstruction by C. thermocellum-from microbe mediated to dynamic redistribution of cellulosomes.

Clostridium thermocellum is one of the most efficient microorganisms for the deconstruction of cellulosic biomass. To achieve this high level of cellu...

Ai derivation and exploration of antibiotic class spaces.

PURPOSE: The rapid evolution of antibiotic-resistant bacteria poses an urgent global health crisis. A key gap in current antibiotic discovery approach...

Machine learning-based typing of Clostridium botulinum group III by FT-IR spectroscopy.

This study aimed to investigate the utility of Fourier-Transform Infrared Spectroscopy (FT-IRS) for differentiating Clostridium botulinum (C. botulinu...

Future Prospects for Using Clinical Phenotypes in Tuberculosis Precision Medicine-An Approach for Clinical Management.

Developing shorter treatment regimens for tuberculosis requires careful characterization of the clinical phenotype, which is defined by patient charac...

Caries Microbiome: time to move from blame to balance.

BACKGROUND: Advances in next-generation sequencing(NGS) and multi-omics approaches reinforced the concept of functional diversity within biofilm commu...