Bacterial Infection

Identification of molecular compounds targeting bacterial propionate metabolism with topological machine learning.

This study demonstrates the transformative potential of machine learning in drug discovery by integrating comparative protein and ligand analysis with novel topological machine learning methods. Our approach sifts through large chemical libraries to identify promising molecular structures for targeting specific proteins with high precision. While many machine learning models have proven effective ...

Artificial intelligence in the diagnosis and prognosis of pediatric bacterial pneumonia: current advances and challenges.

PURPOSE OF REVIEW: The clinical presentation of pediatric bacterial pneumonia often overlaps with that of other respiratory conditions, posing considerable diagnostic challenges. This review evaluates the potential of artificial intelligence to improve diagnostic accuracy and prognostic evaluation for this disease. RECENT FINDINGS: Artificial intelligence driven diagnostic tools for pediatric bact...

AI-Based D-Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug-Resistant Bacterial Infection.

D-amino acid substitution provides an effective strategy for optimizing antimicrobial peptides (AMPs) by enhancing their stability. However, the absen...

Gut dysbiosis in oncology: a risk factor for immunoresistance.

The gut microbiome is recognized as a determinant of response to immune checkpoint inhibitor (ICI) therapies in cancer. However, the clinical translat...

Machine learning reveals sequence and methylation determinants of SaCas9-PAM interactions in bacteria.

Cas9 nucleases defend bacteria against invading DNA and can be used with single guide RNAs (sgRNAs) as antimicrobials and genome-editing tools. Howeve...

Recent advances in gold and zinc oxide nanoparticles: Antibiofilm action, mechanisms beyond ROS generation, and in vivo efficacy.

Gold (Au) and zinc oxide (ZnO) nanoparticles (AuNPs/ZnONPs, respectively) are well-established antimicrobial nanomaterials with broad-spectrum activit...

Automated high-throughput microscopy screening unveiled new Listeria monocytogenes genes involved in cell infection.

To uncover novel genetic factors required for Listeria monocytogenes cell infection, we developed an automated high-throughput microscopy screening pi...

Characteristics of phosphorus-solubilizing bacteria and mediated phosphorus cycle in sediments of urban river-lake interfaces.

Urban river-lake interfaces are crucial areas for substance migration and transformation, and prone to algal blooms. However, the phosphorus (P) cycle...

Non-contact identification of opportunistic pathogens in mixed biofilm contaminations by hyperspectral imaging.

BACKGROUND: Biofilms are present on almost all surfaces in households, healthcare and medical equipment, foods, industrial and water supply systems, a...

α-Helical Peptides Encoded in Collagen Exhibit Antimicrobial Activity with Low Cytotoxicity.

Endogenous antimicrobial peptides (AMPs) derived from host proteins represent a largely underexplored class of natural products tied to innate immunit...

WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield a...

Soil microbial diversity, stability, and function are enhanced by cover cropping: A machine learning-based pooled analysis of Mississippi agroecosystems.

Cover cropping has emerged as a pivotal strategy to enhance soil health and microbiome functionality across diverse agroecosystems. However, the exten...

Machine learning and causal inference applied to the gut metagenome-metabolome axis reveals a link between neonatal jaundice and autism spectrum disorder.

UNLABELLED: Neonatal jaundice (NJ) might increase the risk of autism spectrum disorder (ASD) in children. This study examined whether alterations in t...

Surface-enhanced Raman scattering (SERS) in antibiotic resistance detection: Advances, challenges, and future perspectives.

Antimicrobial resistance (AMR) has emerged as one of the most critical global public health crises, causing an estimated 700,000 deaths annually accor...

Immunoprotective and neuroprotective properties of gut microbiome in psoriasis.

Psoriasis impacts nearly 100 million people globally and is associated with neuropsychiatric comorbidities such as depression and anxiety. With gut mi...

Altered gut microbiome function in ADHD: More Prevotella, less vitamin B12 biosynthesis, and beneficial modulation by synbiotic treatment.

The effect of psychostimulant medication in ADHD on the gut microbiome remains unknown. Oral Synbiotic 2000, comprising multiple lactic acid bacteria ...

Antimicrobial peptides-based strategies at the frontline in battling the escalating menace of methicillin-resistant Staphylococcus aureus biofilms.

Antimicrobial resistance (AMR), particularly in methicillin-resistant Staphylococcus aureus (MRSA), continues to threaten global health due to its mul...

Mechanistic characterisation of AI-2/AIP-mediated quorum sensing governs casein hydrolysis and flavour-protease modulation in acidified milk co-fermented by binary lactic acid bacteria.

Interactions between lactic acid bacteria (LAB) shape the biochemical landscape of dairy fermentations, yet the molecular basis underpinning their syn...

Harnessing biological control and advanced technologies for sustainable wheat rust management: An integrated approach.

Wheat rusts caused by biotrophic fungi of the genus Puccinia continuously threaten global wheat production and food security. The rapid evolution of v...

Stage-specific FeS-mediated regulation of Paracoccus denitrificans during carbon consumption by machine learning-assisted comparative proteomics.

Inorganic electron donors improve low C/N wastewater denitrification performance and management. This study used an integrated strategy combining prot...