Bacterial Infection

Multidimensional cfRNA response modeling identifies a 5-gene pair signature for high-robust pulmonary tuberculosis diagnosis.

Lack of non-invasive biomarkers hinders pulmonary tuberculosis (PTB) management. We developed a multidimensional machine learning framework to systematically evaluate five cell-free RNA (cfRNA)-derived host response modalities: immune cell infiltration, global transcriptional perturbation (expression- and rank-based), key genes, and gene pairs. While immune-cell and global perturbation models show...

Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics.

The gut microbiota (GM) is a pivotal regulator of host metabolism and a contributor to the pathophysiology of obesity, type 2 diabetes (T2D), and metabolic syndrome (MS). Disruptions in GM composition and function are collectively termed dysbiosis. This review synthesizes current evidence on GM dysbiosis, moving beyond simple taxonomic associations, to examine functional drivers of metabolic dysfu...

Exploring the role of phage resistance by using label-free SERS for biochemical profiling of gram-negative pathogen Pseudomonas aeruginosa strains with machine learning approach.

Pseudomonas aeruginosa (P. aeruginosa) is an emerging gram-negative pathogen, accountable for diverse and chronic nosocomial infections, particularly ...

The regional landscape of the human colon culturome in health and cystic fibrosis.

UNLABELLED: Cystic fibrosis (CF) alters gut physiology, yet its impact on microbial communities across colonic regions (ascending, transverse, descend...

Bacterial laccases for green remediation of contaminants of emerging concern: from molecular cloning to metagenomic and computational insights.

Contaminants of emerging concern (CECs) are increasingly recognized for their persistence, widespread occurrence, and potential risks to environmental...

Development and validation of a predictive model for profiling antibiotic resistance phenotypes of Acinetobacter baumannii strains via clinical MALDI-TOF mass spectra: A multicenter study.

Acinetobacter baumannii is a significant pathogen responsible for healthcare-acquired infections (HAIs), posing challenges due to its rising resistanc...

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response.

Plasmid-mediated colistin resistance gene mcr has markedly diminished the effectiveness of colistin in managing multidrug-resistant (MDR) Gram-negativ...

Integrative computational and experimental identification of marine bacterial acetylcholinesterase inhibitors against alzheimer's disease.

Alzheimer's disease (AD) is a powerful neurodegenerative disease characterized by cholinergic deficiency, where the inhibition of acetylcholinesterase...

Specific diagnostic model for bacterial pneumonia constructed by combining multiple omics and multi machine learning models.

Due to the difficulty in quickly discriminating bacterial pneumonia (BPs) from pneumonia caused by other pathogens in clinic, the research for new bio...

Integrated virtual screening, machine learning and molecular dynamics identify novel phytochemical FabI inhibitors against MRSA.

Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a critical global health threat, necessitating the discovery of novel antibacterial...

Label-free saliva screening platform using M13 bacteriophage-based 3D plasmonic structures for MRONJ diagnosis.

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive or antiangiogenic agents, often leading to...

A novel transformer-based platform for the prediction and design of biosynthetic gene clusters for (un)natural products.

Biosynthetic gene clusters (BGCs), comprising sets of functionally related genes responsible for synthesizing complex natural products, are a rich sou...

Integrated in silico and in vitro screening approaches for the discovery of small-molecule inhibitors of β-carbonic anhydrases.

INTRODUCTION: β-Carbonic anhydrases (β-CAs) are zinc-dependent metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate ...

Harnessing AMF-plant-microbe systems for heavy metal remediation.

Soil heavy metal pollution poses a global environmental threat, demanding effective and sustainable remediation strategies. Arbuscular mycorrhizal fun...

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects.

Cancer immunotherapy is increasingly moving toward personalized, precision-based strategies, with cancer vaccines emerging as a promising approach to ...

Scale-Dependent Heterogeneity Drives Microbial Insurance in Phyllosphere Algal-Bacterial Networks during Lake Eutrophication.

The algal-bacterial symbiotic communities within the submerged macrophyte phyllosphere exhibit significant potential for lake restoration. However, th...

From fermentation to function: a critical review of lactic acid bacteria redesign for functional foods and precision nutrition.

Lactic acid bacteria (LAB) have transitioned from their traditional roles in food preservation and flavor enhancement to more advanced applications su...

Screening for Clinically Significant Nephrolithiasis Based on Simple Health Checkup Clinical and Urine Parameters in General Populations: Multicenter Machine Learning Study.

BACKGROUND: Nephrolithiasis affects approximately 15% of the population and often remains undetected in asymptomatic individuals. Current diagnostic a...

Metabolic Fingerprint-Mediated Chemical Nose Strategy: Precise Identification of Foodborne Bacteria Based on a 4-MU Derivative Fluorescence Array.

Accurate identification of foodborne microorganisms is a key priority for food safety. Focused on the common principles of microbial metabolism, a met...

Green in-situ photoreduction synthesis of SERS substrates based on violet phosphorus arrays/silver nanoparticles for ultrasensitive detection and accurate identification of UTI bacteria.

Surface-enhanced Raman spectroscopy (SERS) holds significant promise for identifying urinary tract infection (UTI) pathogens due to its exceptional se...