Bacterial Infection

Species-specific discrimination of bacterial biofilms using a ratiometric fluorescence sensor array and machine learning.

Biofilms are intricate bacterial communities encased in a self-produced extracellular matrix (ECM) of DNA, lipids, proteins, and polysaccharides. The diverse ECM composition across bacterial species significantly influences the progression of biofilm-associated infections, making precise identification crucial for effective treatment. Traditional methods such as biochemical assays, MALDI-TOF mass ...

Toward indole postbiotics precision therapy via AI-powered drug delivery technologies.

Recent advancements in microbiome research have revealed the restorative capacities of postbiotics, including indole and its derivatives generated via bacterial tryptophan metabolism. Widespread in prokaryotic and eukaryotic communities, indole and its derivatives are uniquely suited to promote host physiology and homeostasis at the host/microbe interface. In addition to suppressing the bacterial ...

Zoonoticus: A machine learning model for genomic prediction of zoonotic bacterial strains using virulence, resistance, and mobile genetic elements.

Zoonotic diseases continue to rise globally, yet no existing genomic tool integrates virulence, antimicrobial resistance (AMR), and mobile genetic ele...

The application of machine learning in the evaluation of urinary tract infections incidence in patients in a Nursing and Treatment Facility.

BACKGROUND: Urinary tract infection (UTI) is a serious problem in the healthcare system. It is caused by bacteria from the gastrointestinal tract. The...

Modeling and forecasting vibrio vulnificus concentration of long-range dependence on marine environmental conditions.

Vibrio vulnificus (vvh) is an epidemiologically significant bacterium that naturally occurs in coastal waters under favorable environmental conditions...

Algal-bacterial granular sludge process for sustainable wastewater treatment: Technological advances and challenges.

The algal-bacterial granular sludge (ABGS) process is a promising solution for sustainable wastewater treatment, owing to its synergistic contaminant ...

Diagnosis of Acute, Chronic (with and without Nasal Polyps), and Fungal Sinusitis.

Rhinosinusitis is a spectrum of diseases with varied causes, presentations, and diagnostic approaches-from viral and bacterial acute rhinosinusitis to...

Influences of growth media and culture time on the SERS spectral patterns of three common pathogenic bacteria: a comparative analysis.

Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful tool for clinical microorganism identification, offering significant advantages o...

4-Hydroxy-2,5-dihydrothiazole derivatives as a new class of small-molecule antibiotics for MRSA: AI-integrated design, chemical synthesis and biological evaluation.

Staphylococcus aureus (S. aureus) is one of the most concerned Gram-positive bacteria due to its resistance to the commonly used antibiotics, methicil...

Genomic and Transcriptomic Profiling of High-risk Bladder Cancer Reveals Diverse Molecular and Microenvironment Ecosystems.

BACKGROUND AND OBJECTIVE: High-risk bladder cancer recurs in 30% of cases and causes fatal outcomes in 10% within 2 yr despite surgical resection, end...

Distinctive Properties of Mla Proteins Differentiate Them From Classical ABC Transporter Components.

In Gram-negative bacteria, the non-canonical ABC transporter, namely, maintenance of lipid asymmetry (Mla) system, ferries phospholipids (PLs) between...

Multidrug-resistant pathogens in UTIs: A concise review of epidemiology, diagnostics, and patent landscaping for precision healthcare.

UTIs are regarded as the second most prevalent global problem, with 150 to 250 million cases reported annually. Poor hygiene, anatomical abnormalities...

Deep learning-based cross-device standardization of surface-enhanced Raman spectroscopy for enhanced bacterial recognition.

Surface-enhanced Raman spectroscopy (SERS) is a powerful, label-free technique for pathogen detection; however, its broader adoption in clinical diagn...

Bu Zhong Yi Qi Tang targets key monocyte-associated genes to enhance sepsis therapy.

ETHNOPHARMACOLOGICAL RELEVANCE: Sepsis is a life-threatening condition resulting from an uncontrolled immune response to infection, leading to organ d...

Metagenomics reveals potential antimicrobial peptides in Chinese baijiu fermentation.

Antimicrobial peptides (AMPs) from food fermentation microbiota hold promise for food preservation and as potential antimicrobial agents. However, the...

IQSPred-PLM: An Interpretable Quorum Sensing Peptides Prediction Model Based on Protein Language Model.

Quorum sensing regulates cooperative behaviors in bacteria through the accumulation and detection of signaling molecules. This process plays a crucial...

Machine Learning-Aided Meta-Analysis Reveals Changes in Penaeus vannamei Gut Bacterial Communities Upon Dietary Supplementation-Induced Immunostimulation.

Gut bacterial communities play a key role in shrimp health; thus, their modulation has been a target of dietary supplements which also function in enh...

Algal/bacterial membrane bioreactor for bioremediation of hazardous landfill leachate containing 1,4-dioxane: An artificial neural network modeling.

This study developed an artificial neural network (ANN) model to predict the 1,4-dioxane removal efficiency from hazardous landfill leachate treated b...

An update on experimental to large-scale production of bacteriophages against superbugs: a review.

The escalating problem of antibiotic resistance has sparked renewed interest in bacteriophages (phages) as potential substitutes for conventional anti...

A Machine Learning Approach to Microcalorimetric Pattern Classification of Pathogens in Synovial Fluid.

Isothermal microcalorimetry (IMC) is a promising tool for diagnosing periprosthetic joint infection (PJI), based on real-time measurement of growth-re...