Bacterial Infection

Pharmacokinetics and Customized Dosing of Vancomycin in Adult Patients With Hematological Malignancies: Status, Challenges, and Opportunities.

Vancomycin (VAN) remains the first-line treatment for methicillin-resistant, multidrug-resistant gram-positive bacterial infections, even among cancer patients. Patients with hematological malignancies (HMs) represent a unique population, whose physiological and pathological changes often differ from those of the general population. These variations may cause significant alterations in the in vivo...

Gut microbiome signatures associated with depression and obesity.

UNLABELLED: Depression and obesity are highly comorbid and likely involve common risk factors and pathophysiological mechanisms, which could crosslink to gut microbiome dysfunction. Here, we performed a case-control study with a total of 105 subjects, 43 with major depressive disorder (MDD) and 62 non-depressed controls free from psychiatric comorbidities, to identify gut microbiome signatures ass...

Agri-vision Bangladesh: A multi-crop augmented image dataset for automated disease diagnosis in Bottle Gourd, Zucchini, Papaya, and Tomato.

This article introduces Agri-Vision Bangladesh, a comprehensive, augmented image dataset designed to advance automated disease diagnosis in four econo...

Motion as a Language: Transformer-Based Classification of Antimicrobial Peptide Conformational Dynamics.

Antimicrobial peptides (AMPs) represent a promising alternative to traditional antibiotics against which many bacteria are rapidly gaining resistance....

Evaluation of a machine learning system for genomic antimicrobial susceptibility determination on a clinically representative test set.

UNLABELLED: Next-generation sequencing is anticipated to transform infectious disease treatment by enabling faster diagnosis, yet a clinical-grade met...

Stage-wise environmental recovery patterns and cross-domain interactions of planktonic bacterial communities in Zhanjiang Bay following typhoon disturbance.

Typhoon events can abruptly alter local biogeochemical cycles, which may strongly influence microbial community structure and ecological interactions....

Bacterial fructan-metabolizing enzymes: modular architecture and biotechnological potential.

Bacterial fructan-metabolizing enzymes exhibit substantial structural and mechanistic diversity to support their biotechnological uses. Recent finding...

Microbiome-Based Modeling of CAR-T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing.

The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell-driven cancer immunotherapies. How...

Bioinspired Multifunctional Hydrogels for Deep Learning-Enabled Wound pH Visual Monitoring and Treatment.

Smart wound dressings capable of real-time environmental monitoring and therapeutic intervention are crucial for managing difficult-to-heal wounds. He...

Confidence-based prediction of antibiotic resistance at the patient level.

Rapid and accurate diagnostics of bacterial infections are necessary for efficient treatment of antibiotic-resistant pathogens. Cultivation-based meth...

Structure-based and machine learning-assisted identification of natural phytochemicals targeting Mycobacterium leprae InhA for anti-mycobacterial therapeutics.

Mycobacterium leprae (M. leprae) is the bacterium that causes leprosy. It is a public health problem in many regions, especially in developing countri...

Optical photothermal infrared (OPTIR) spectroscopy assisted by machine learning for lactic acid bacteria identification at strain level.

Lactic acid bacteria (LAB) are widely used in food, health, and biotechnology sectors, where accurate strain level identification is critical. Convent...

Smartphone-based multispectral autofluorescence analysis of bacteria mixtures of staphylococci using convolutional neural network.

Improved screening for pulmonary Kaposi sarcoma in a low-resource setting.

OBJECTIVE: The lung is commonly involved in advanced Kaposi sarcoma (KS) but diagnosis of pulmonary KS in low-resource settings is difficult. Clinical...

SERS technology helps bacterial inactivation in vivo: including detection, identification, and evaluation.

The problem of bacterial infection and antimicrobial resistance has become a major challenge threatening to human health. Detection, identification, a...

Engineered Supramolecular Therapeutics in Development for Combating Antibiotic-Resistant Bacterial Infections.

The emergence of antibiotic-resistant bacteria has rendered conventional antibiotic treatments ineffective, necessitating the development of antibacte...

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.

Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer's disease (AD), but its role in retinal pathology and disease progression i...

Machine learning reveals ecological thresholds and predicts future bacterial community shifts in a chronically eutrophic estuary.

Effectively managing eutrophic estuaries under climate change requires a quantitative understanding of how microbial communities respond to multiple e...

Targeted SERS Nanoparticle Accumulation on Bacteria Enables On-Site Accurate Vibrio Typing in 10 min with AI-Powered SERS.

Vibrio infections progress rapidly with high mortality, yet current diagnostics fail to meet the critical need for rapid, accurate, and field-deployab...

Vancomycin resistance in gram-positive infections: evolutionary strategies of survival.

Vancomycin is a critical glycopeptide antibiotic for treating severe infections caused by Gram-positive bacteria, particularly MRSA and Clostridioides...