Bacterial Infection

Rapid detection of antibiotic resistance in Burkholderia pseudomallei using MALDI-TOF mass spectrometry.

Antibiotic resistance in Burkholderia pseudomallei (Bp) is a growing public health concern requiring urgent attention. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a rapid bacterial identification tool with potential for future diagnostic applications. This study investigates differences in MALDI-TOF spectra of antibiotic-resistant Bp s...

Construction and validation of HBV-ACLF bacterial infection diagnosis model based on machine learning.

OBJECTIVE: To develop and validate a novel diagnostic model for detecting bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) using advanced machine learning algorithms. The focus is on improving early clinical identification and interpretability.

Automatic recognition and differentiation of pulmonary contusion and bacterial pneumonia based on deep learning and radiomics.

BACKGROUND: In clinical work, there are difficulties in distinguishing pulmonary contusion(PC) from bacterial pneumonia(BP) on CT images by the naked ...

Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.

BACKGROUND: Reversal reactions (RR) in leprosy are acute immune episodes marked by inflammation and bacterial clearance, offering a model to study the...

CRCpred: An AI-ML tool for colorectal cancer prediction using gut microbiome.

Colorectal cancer (CRC) is a leading cause of death worldwide. A plethora of research shows the alteration of the gut microbiome and the association o...

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues.

Dynamic changes occurring in the lung microbiota can impact the initiation, progression, and prognosis of lung cancer (LC). Consequently, the developm...

Unveiling the role of microbial rease in ureolysis-induced calcium carbonate precipitation, Its mechanistic insights, and emerging applications.

Urease (urea amidohydrolase, EC 3.5.1.5) is a metalloenzyme that catalyzes the hydrolysis of urea into ammonia and carbamate, playing a pivotal role i...

Photocatalytic microrobots for treating bacterial infections deep within sinuses.

Microrobotic techniques are promising for treating biofilm infections located deep within the human body. However, the presence of highly viscous pus ...

Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis.

INTRODUCTION: The WHO's Integrated Management of Childhood Illness (IMCI) in young infants <2 months of age includes the identification and management...

Attention-driven UNet enhancement for accurate segmentation of bacterial spore outgrowth in microscopy images.

Analyzing microscopy images of large growing cell samples using traditional methods is a complex and time-consuming process. In this work, we have dev...

Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.

Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare setting...

Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.

Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this wor...

Melioidosis molecular diagnostics: An update.

Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, os...

Trade-off between resistance and persistence in high cell density cultures.

Bacterial growth to high cell densities is commonly observed in infections, microbiomes, and biomanufacturing, yet there is limited understanding of h...

Prediction of Antibiotic Resistance Phenotypes and Minimum Inhibitory Concentrations in Using Machine Learning Analysis of Its Pan-Genome and Pan-Resistome Features.

Traditional experimental methods for determining antibiotic resistance phenotypes (ARPs) and minimum inhibitory concentrations (MICs) in bacteria are ...

Mucosal immune responses and intestinal microbiome associations in wild spotted hyenas (Crocuta crocuta).

Little is known about host-gut microbiome interactions within natural populations at the intestinal mucosa, the primary interface. We investigate asso...

Identification of bacterial infection types in decomposition stages at various temperatures using pathology images and artificial intelligence algorithms.

Bacterial infections present a significant threat to human health, and accurate identification of infection type is crucial for both clinical and fore...

Implementation costs and cost-effectiveness of ultraportable chest X-ray with artificial intelligence in active case finding for tuberculosis in Nigeria.

Availability of ultraportable chest x-ray (CXR) and advancements in artificial intelligence (AI)-enabled CXR interpretation are promising developments...

High-Throughput Analysis of Protein Adsorption to a Large Library of Polymers Using Liquid Extraction Surface Analysis-Tandem Mass Spectrometry (LESA-MS/MS).

Biomaterials play an important role in medicine from contact lenses to joint replacements. High-throughput screening coupled with machine learning has...

Widespread distribution of bacteria containing PETases with a functional motif across global oceans.

Accumulating evidence indicates that microorganisms respond to the ubiquitous plastic pollution by evolving plastic-degrading enzymes. However, the fu...