Bacterial Infection

α-Helical Peptides Encoded in Collagen Exhibit Antimicrobial Activity with Low Cytotoxicity.

Endogenous antimicrobial peptides (AMPs) derived from host proteins represent a largely underexplored class of natural products tied to innate immunity. Here, we investigated collagen proteins as a source of latent α-helical AMPs encoded within nonfibrous extracellular matrix domains. Using a targeted in silico approach, verified collagen sequences were mined and prioritized based on secondary str...

WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances in genomic resources and multi-omics approaches have accelerated the identificat...

Soil microbial diversity, stability, and function are enhanced by cover cropping: A machine learning-based pooled analysis of Mississippi agroecosystems.

Cover cropping has emerged as a pivotal strategy to enhance soil health and microbiome functionality across diverse agroecosystems. However, the exten...

Machine learning and causal inference applied to the gut metagenome-metabolome axis reveals a link between neonatal jaundice and autism spectrum disorder.

UNLABELLED: Neonatal jaundice (NJ) might increase the risk of autism spectrum disorder (ASD) in children. This study examined whether alterations in t...

Surface-enhanced Raman scattering (SERS) in antibiotic resistance detection: Advances, challenges, and future perspectives.

Antimicrobial resistance (AMR) has emerged as one of the most critical global public health crises, causing an estimated 700,000 deaths annually accor...

Immunoprotective and neuroprotective properties of gut microbiome in psoriasis.

Psoriasis impacts nearly 100 million people globally and is associated with neuropsychiatric comorbidities such as depression and anxiety. With gut mi...

Altered gut microbiome function in ADHD: More Prevotella, less vitamin B12 biosynthesis, and beneficial modulation by synbiotic treatment.

The effect of psychostimulant medication in ADHD on the gut microbiome remains unknown. Oral Synbiotic 2000, comprising multiple lactic acid bacteria ...

Antimicrobial peptides-based strategies at the frontline in battling the escalating menace of methicillin-resistant Staphylococcus aureus biofilms.

Antimicrobial resistance (AMR), particularly in methicillin-resistant Staphylococcus aureus (MRSA), continues to threaten global health due to its mul...

Mechanistic characterisation of AI-2/AIP-mediated quorum sensing governs casein hydrolysis and flavour-protease modulation in acidified milk co-fermented by binary lactic acid bacteria.

Interactions between lactic acid bacteria (LAB) shape the biochemical landscape of dairy fermentations, yet the molecular basis underpinning their syn...

Harnessing biological control and advanced technologies for sustainable wheat rust management: An integrated approach.

Wheat rusts caused by biotrophic fungi of the genus Puccinia continuously threaten global wheat production and food security. The rapid evolution of v...

Stage-specific FeS-mediated regulation of Paracoccus denitrificans during carbon consumption by machine learning-assisted comparative proteomics.

Inorganic electron donors improve low C/N wastewater denitrification performance and management. This study used an integrated strategy combining prot...

Automating wound assessment: convolutional neural network-based mobile application for SINBAD classification system.

INTRODUCTION: Diabetic foot ulcer (DFU) assessment using the SINBAD system is essential for clinical decision-making but often limited by access to sp...

Machine Learning in Microbiome Research and Engineering.

Microbiomes, complex communities of microorganisms and their genetic material, hold immense potential for addressing global challenges in diverse sect...

Boosting Array-based Diagnosis of Urinary Tract Infections via a Heterobifunctional Bridge-Driven Strategy.

Array-based sensing platforms have witnessed significant progress in recent years, demonstrating considerable potential for high-throughput and multip...

Supragingival Biomarker flora of Children With and Without Cariogenic Disease and Black Stains, Aged 3 to 6 Years.

BACKGROUND: The oral microbiome plays a pivotal role in the occurrence and progression of dental caries and black stain (BS) pigment. OBJECTIVES: The ...

AI-Based Exhaled VOC Panels as Gut Microbiota-Derived Biomarkers for IBD Screening.

Inflammatory bowel diseases (IBD) present significant diagnostic and therapeutic challenges due to their heterogeneity. Here, we analyze exhaled volat...

SemiRaman: A self-supervised contrastive representation learning-based framework for semi-supervised Raman spectral identification of pathogenic bacteria.

Raman spectroscopy has established itself as a robust and non-invasive approach for the precise identification of pathogenic bacteria. The fusion of R...

Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities.

Burkholderia pseudomallei (BP) infections claims tens of thousands of lives worldwide every year. The bacterium's distinctive characteristics include ...

Population heterogeneity revealed in morphometric analysis of densely populated microbial swarm collectives.

UNLABELLED: Uncovering cell morphology within communities is crucial to understanding how collective groups of organisms can function and adapt to the...

Targeting the DYNLL2-PAK1 axis inhibits caspase-11-dependent pyroptosis to alleviate sepsis.

Sepsis, a life-threatening syndrome caused by dysregulated host responses to infection, lacks effective therapeutic strategies due to its complex immu...