Bacterial Infection

Mechanisms, management and prevention of anorectal sexually transmitted infections.

Anorectal bacterial sexually transmitted infections, predominantly chlamydia, gonorrhoea and syphilis, represent a substantial and evolving global health challenge, with incidence rising despite widespread testing availability. In this Review, we examine the epidemiology and burden of anorectal sexually transmitted infections, explore the pathogenic mechanisms underlying infection and discuss adva...

Epigallocatechin gallate inhibits high-fat/choline diet-induced trimethylamine production via regulation of intestinal Serratia and Lactobacillus communities.

High-fat/choline diets can induce the production of the enterogenous metabolite trimethylamine-N-oxide (TMAO). TMAO is synthesized from its precursor trimethylamine (TMA), which is generated via choline cleavage catalyzed by choline trimethylamine-lyase/choline TMA-lyase-activating enzyme (CutC/D) expressed by gut microbes; subsequently, TMA is oxidized to TMAO by flavin-containing monooxygenase 3...

Innovative approaches to therapeutic target discovery amid the global challenge of antimicrobial resistance.

Antimicrobial resistance is a constant threat to global public health, requiring innovative strategies for therapeutic target identification. Hence, t...

Quorum-sensing, microbiome interactions, and emerging artificial intelligence-assisted anti-virulence strategies in Salmonella Typhi: a critical review of translational opportunities and challenges.

Typhoid fever, caused by Salmonella enterica subsp. enterica serovar Typhi (Salmonella Typhi), remains a significant global health challenge that is i...

Bacterial triosephosphate isomerase as a therapeutic target, current knowledge and future perspectives: A review.

Triosephosphate isomerase (TIM) is a very efficient catalyst due to its precise dynamic architecture. Most of the structural, functional, and physicoc...

Jianpi Bushen Qingchang Huashi formula alleviates DSS-induced colitis through butyrate-associated HDAC1 inhibition and Th17/Treg homeostasis.

ETHNOPHARMACOLOGICAL RELEVANCE: Jianpi Bushen Qingchang Huashi Formula (JBQHF) is a traditional Chinese medicine compound of nine herbal ingredients c...

Guideline Concordance of Large Language Model Responses to Parent-oriented Guideline Prompts About Pediatric Acute Bacterial Arthritis.

BACKGROUND: Large language models (LLMs) are increasingly used by patients and caregivers to obtain medical information. In pediatric acute bacterial ...

An Engineered Multicellular Bacterial Network for Simultaneously Answering Multiple Computational Decision Problems.

Living cell-based computers are in their infancy and answering multiple computational decision problems by a single system remains a key challenge. He...

A custom GPT-based model for the automated analysis and interpretation of antimicrobial susceptibility tests in Gram-negative bacteria.

INTRODUCTION: Antimicrobial resistance in Gram-negative bacilli represents a growing clinical challenge that demands innovative tools to optimize anti...

Designing fiber-gut microbiome interactions with active learning.

Identifying synergies between dietary fibers and beneficial bacteria holds promise for precision interventions that optimize gut health, yet these int...

Integrating network pharmacology, machine learning, and molecular docking to explore the therapeutic mechanisms of Huangqin in atopic dermatitis: A STROBE-compliant observational study.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder with complex pathogenesis, and current therapies face limitations in efficacy and safet...

Integrated Genome-Wide Association Study and Machine Learning Approach for Characterizing the Determinants of Biofilm Formation in Staphylococcus aureus.

Staphylococcus aureus (S. aureus) is a well-recognized pathogen known for its multi-drug resistance and diverse virulence mechanisms. Its ability to g...

Metagenomic screening of antimicrobial peptide candidates and isolation of two active peptides from bat gut bacteria.

Bacterial antibiotic resistance has intensified the need to identify new antimicrobial molecules from underexplored microbial systems. Wild mammalian ...

AI-Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis.

Bacterial osteomyelitis remains a formidable challenge in clinic because existing monotherapies fail to block inevitable infection, uncontrolled infla...

From sequence space to ecological function: microbiome-derived antimicrobial peptides as community effectors and therapeutic leads.

Antimicrobial peptide research has long centred on host defence molecules, yet microbiomes themselves encode a diverse and increasingly important repe...

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.

Antibiotic heteroresistance is a form of within-isolate susceptibility heterogeneity in which an apparently susceptible bacterial population contains ...

In silico identification and biophysical characterization of candidate antimicrobial peptides from the Indian marine microbiome targeting multidrug-resistant ESKAPE pathogens.

The global health crisis of antimicrobial resistance necessitates the discovery of new antibacterial agents. Underexplored marine microbiomes, particu...

COVLIAS 3.5: integration of attention-based segmentation technique with fuzzy dilated convolutional neural networks for improved classification of chest X-ray scans for multiclass pneumonia diagnosis.

This study aims to improve pneumonia diagnosis by integrating attention-based U-Net models for lung segmentation with fuzzy logic-enhanced CNNs for cl...

Identification of Microbiome Associations with Tacrolimus Pharmacokinetics in Adult Hematopoietic Cell Transplantation Using Population Pharmacokinetic and Machine Learning.

PURPOSE: Tacrolimus (TAC) is known for its high pharmacokinetic variability which cannot be fully explained by pharmacogenomic (PGx) and clinical vari...

Regenerable "Two-in-One" molecularly imprinted nanozymes colorimetric sensor array combined with deep learning enables selective removing and visual discriminate of tetracycline antibiotics.

Tetracycline (TC) and its analogues are widely employed broad-spectrum antibiotics. Their abuse and environmental residues have raised severe ecologic...