Bacterial Infection

Living bacterial reservoir computers for information processing and sensing.

We introduce a systems-level approach to sensing and computing in which Escherichia coli acts as a living reservoir computer, performing complex information processing through its native growth responses without requiring genetic modification or specialized instrumentation. We validate this framework by accurately classifying early-stage COVID-19 plasma samples according to subsequent disease seve...

Machine learning driven forward-reverse design of Ag-ZnO-PEEK nanocomposites for sustainable biomass and lipid enhancement in Chlorella vulgaris AK_123 with integrated anti-bacterial activity.

At present, the realm of nanobionics has garnered significant attention for its potential applications in microalgal systems, offering innovative strategies to augment growth, productivity, and metabolic performance. Present study influences nanotechnology to explore the multifaceted effects of novel biocompatible nanocomposite Ag-ZnO-PEEK (silver-zinc oxide- Polyether Ether Ketone) on isolated mi...

Characterization and determination of the immunomodulatory activity of intestinal microbiota microorganisms isolated from free-range Cornu aspersum snails in olive groves before and after aestivation.

The present study investigated the impact of aestivation of free-range snails on the intestinal microbiota and its potential to protect the host from ...

Rapid delineation of Acinetobacter baumannii dose responses to zosurabalpin based on machine learning-assisted interpretation of bacterial nanomotions.

UNLABELLED: Carbapenem-resistant Acinetobacter baumannii (CRAB) represents a major clinical threat, underscoring the urgent need for both new antibiot...

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.

The ability of compounds to permeate and accumulate in bacterial cells is a critical determinant of antibiotic efficacy. Better therapeutics are urgen...

Plant-derived compounds and artificial intelligence: Outsmarting microbial pathogens and antimicrobial resistance.

BACKGROUND: From the discovery of the first antimicrobial drug to nowadays, the development of antimicrobial resistance (AMR) - a silent pandemic amon...

Antimicrobial peptide hydrogel delivery systems: Design strategies and functional expansion.

Antimicrobial peptides (AMPs), owing to their unique membrane-disrupting mechanism and low susceptibility to resistance, represent important candidate...

Bacterial keratitis: a global review of current practices, challenges and innovations.

Bacterial keratitis is a major cause of corneal blindness worldwide, with marked differences in clinical presentation and risk factors across regions....

TACE-induced liver injury in hepatocellular carcinoma: mechanisms, prediction, and prevention in the era of gut microbiota and inflammasome research.

Transarterial chemoembolization (TACE) is a cornerstone locoregional therapy for hepatocellular carcinoma (HCC), yet most candidates also have cirrhos...

Predicting antimicrobial resistance for precision medicine.

Antibiotics are among medicine's greatest successes, but resistance evolution threatens their continued efficacy. Decades of research have deepened ou...

Associations of indoor bacterial, metabolomic, and other chemical exposures with allergic rhinitis in school-aged children.

BACKGROUND: The indoor environment has been implicated as a critical factor in the development of allergic diseases. However, the interplay among indo...

[A two-stage model for predicting postoperative pulmonary infection in esophageal cancer patients].

Postoperative pulmonary infection (PPI) after esophageal cancer surgery occurs frequently and severely impairs patients' prognosis. Most existing pred...

Protocols for genomic epidemiology and source attribution of enteric bacteria causing diarrhoeal disease across Africa.

INTRODUCTION: Enteric bacterial pathogens are a major cause of diarrhoeal disease in low-income and middle-income countries, with complex transmission...

Bioinformatics classification of the MgtE Mg 2 + channel and de novo protein design for the stabilization of its novel subclass.

MgtE channels play crucial roles in Mg 2 + homeostasis and are implicated in bacterial survival under antibiotic exposure. Previous structural and bio...

Discovery of novel antimicrobials within microbiomes.

Antimicrobial-resistant bacterial and fungal pathogens constitute a severe threat to public health. The pace at which new antimicrobials are being rel...

Motion-refined machine learning enables characterization of bacterial swarming dynamics.

Bacterial swarming on a semi-solid agar surface is a prevalent form of collective motility. Our study focuses on probing the swarm front of a novel sp...

Annexin A2 as a Therapeutic Target of Artemisiae Scopariae Herba-derived Quercetin in Preventing Malignant Progression from Primary Sclerosing Cholangitis to Cholangiocarcinoma: An Integrative Study.

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisiae Scopariae Herba (ASH) is traditionally used to treat cholestatic liver diseases and exhibits anti-tumour po...

Enhanced identification of key bacterial motility genes via a cross-species genomic hybrid feature machine learning approach.

Efficient and accurate identification of functional genes is critical to biological research, yet traditional single-species approaches are often limi...

Genetically engineered outer membrane vesicles as next-generation bionanomaterials for therapeutic and diagnostic applications.

Outer membrane vesicles (OMVs), naturally released by Gram-negative bacteria, represent a unique class of bionanomaterials with inherent immunogenicit...

Comparison of Gram stain interpretation accuracy between a computer-aided diagnosis app and microbiology specialists in blood culture samples.

UNLABELLED: Gram staining is one of the basic tests to identify the organism in microbiological laboratory, especially in blood culture. However, micr...