Infectious Disease

Bacterial Infection

Latest AI and machine learning research in bacterial infection for healthcare professionals.

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MoCETSE: A mixture-of-convolutional experts and transformer-based model for predicting Gram-negative bacterial secreted effectors

Identifying effector proteins of Gram-negative bacterial secretion systems is crucial for understand...

Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces

The rise of antimicrobial resistance, especially among gram-negative ESKAPE pathogens, presents an u...

Tripleknock: predicting lethal effect of three-gene knockout in bacteria by deep learning

Investigating the lethal effect of multi-gene knockout is essential for discovering novel antibiotic...

HPInet: Interpretable prediction of Host-Pathogen protein-protein Interactions using a transformer-based neural network

Gram-negative bacteria utilize a series of secretion systems (T1SS-T10SS) to deliver secreted effect...

Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes

Variation within the prokaryotic pangenome is not random, and natural selection that favours particu...

PAM adenine methylation and flanking sequence regulate SaCas9 activity in bacteria

Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to re...

The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation in Escherichia coli

The mechanisms by which two sister chromosomes separate and partition into daughter cells in bacteri...

Moremi Bio Agent: Leveraging Agentic Large Language Model for the Discovery of Broad-Spectrum Antibiotics for Enterobacteriaceae

Antimicrobial resistance (AMR) is a pressing global health crisis, exacerbated by a stagnating antib...

Intra-genomic genes-to-genes correlation enables bacterial genome representation

The bacterial pan-genome consists of core genes shared by all members of a taxonomy and accessory ge...

Accurate and robust classification of Mycobacterium bovis-infected cattle using peripheral blood RNA-seq data

The zoonotic bacterium, Mycobacterium bovis, causes bovine tuberculosis (bTB) and is closely related...

Large-language-model-based antibiotic resistance gene prediction and resistomes mining in cyanobacterial blooms

The rapid spread of antibiotic resistance genes (ARGs) in aquatic ecosystems poses a serious public ...

ppIRIS: deep learning for proteome-wide prediction of bacterial protein-protein interactions

Protein–protein interactions (PPIs) are central to cellular processes and host–pathogen dynamics, ye...

Scalable and interpretable secretion system annotation with Sismis

Secretion systems play critical roles in bacterial growth, survival, and pathogenesis. Genes encodin...

PhageAI: a new approach to predicting the lifestyle of bacteriophages using proteinBERT and convolutional neural networks

Bacteriophages are viruses that infect bacteria, including temperate, virulent and chronic phages. I...

Species-agnostic and Salmonella-specific Models for Antimicrobial Resistance Prediction Using FCGR and ResNet-18

Antimicrobial resistance (AMR) prediction from bacterial genomes remains a major challenge for clini...

Breaking the culture habit: metagenomic diagnosis of companion animal skin infections

Skin infections have been described as the primary cause for presentation in veterinary small animal...

A deep reinforcement learning platform for antibiotic discovery

Antimicrobial resistance (AMR) is projected to cause up to 10 million deaths annually by 2050, under...

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