Bacterial Infection

Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA.

Rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) is crucial for early optimization of antibiotic treatment, but current routine susceptibility testing typically requires 48-72 h. Attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy has emerged as a promising approach for bacterial identification and has recently been used to distinguish MRSA fro...

Ranked placement of phage predation as a determinant of dehydration severity among cholera patients in Bangladesh.

Virulent bacteriophages (phages) can kill bacterial prey, potentially reducing burden of infection. In cholera, a high phage to Vibrio cholerae ratio is associated with mild dehydration, yet the relative importance of this ratio in disease severity remains unclear. We used machine learning to rank select host, microbial, and environmental factors as determinants of dehydration severity in over 600...

Oral and Maxillofacial Surgery research hotspots and emerging trends in 2025: A targeted bibliometric analysis.

OBJECTIVES: To perform a targeted bibliometric analysis of the Oral and Maxillofacial Surgery (OMFS) literature from 2025 to map its current intellect...

Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.

The stable structure of biofilms and the characteristics of the bacteria within them make biofilms an important barrier for bacteria to resist externa...

Gut fungal signatures in colorectal cancer and their potential for supporting diagnosis: a multi-cohort metagenomic analysis.

BACKGROUND: Colorectal cancer (CRC) is influenced by host factors and environmental exposures that shape gut microbial ecosystems. Although bacterial ...

From Correlation to Causality: Identifying Potential Environmental Drivers of Pathogenic Antibiotic-Resistant Bacteria in River Water Using Causal Machine Learning.

Pathogenic antibiotic-resistant bacteria (PARB) pose a serious public health threat within the One Health framework, yet identifying their potential e...

Classification of bacterial images obtained optically using some pre-trained models.

Rapid and accurate detection of water-borne bacteria is critical for safeguarding public health and preventing the spread of infections. Conventional ...

Machine Learning Approaches Using High-Throughput Profiling Data for Antibiotic Discovery.

Antibiotic-resistant bacterial infections continue to increase globally, creating an urgent need for new antibacterials with novel mechanisms of actio...

Exploring the gut-lung axis in post-liver transplant acute lung injury: A multi-omics approach.

Acute lung injury (ALI) is a significant post-operative complication of liver transplant (LT), with mounting evidence suggesting a role for the gut-lu...

A deep learning system for bacterial identification and resistance prediction from MALDI-TOF data.

Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) data contain underutilized information beyond species id...

Ceramsite-mediated enrichment of functional bacteria in biofilters: a novel strategy for simultaneous ammonia and hydrogen sulfide removal in livestock odor control.

Livestock farming odors, particularly those caused by ammonia and hydrogen sulfide, pose significant environmental and public health challenges. This ...

An interpretable machine-learning model for post-admission reassessment of bloodstream infection risk in ICU patients with pneumonia.

The aim of this study is to develop and validate a machine learning-based predictive model to assess the risk of acquired bloodstream infection (BSI) ...

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning.

The human gut microbiome plays a vital role in regulating host physiological functions and influencing the pharmacokinetics of interventions, particul...

A pH-Responsive Antimicrobial Peptide Coating with Efficient Antibacterial Activity and Preserved Oral Microbiota Homeostasis during Clear Aligner Treatment.

Bacterial adhesion and biofilm formation pose significant clinical challenges in clear aligner therapy, adversely affecting both oral health and aesth...

Computational approaches for identifying quorum sensing inhibitors.

Quorum sensing (QS) is a critical cell-to-cell communication mechanism employed by microorganisms to coordinate their collective behaviors, including ...

Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species.

Pseudouridine (Ψ) modifications are the most abundant RNA modifications; however, their distribution and functional significance in bacteria remain la...

Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization.

In hematopoietic cell transplant (HCT) patients, intestinal Candida parapsilosis expansion and translocation can cause life-threatening candidemia, ye...

Impact of nanocarrier mediated drug delivery systems: a deep dive into therapeutics and clinical management of breast cancer.

Breast cancer (BC) is the most frequently diagnosed malignancy and the leading cause of cancer-related death among women worldwide. The therapeutic li...

Genomic and socioeconomic drivers of antimicrobial resistance forecast to 2050.

Antimicrobial resistance (AMR) is rising worldwide, and a better understanding of the genetic and socioeconomic determinants tied to it may establish ...

De Novo Design of Membrane-Targeting Antimicrobial Peptides Against Gram-Negative Bacteria Using a Generative Artificial Intelligence Framework.

Antimicrobial resistance (AMR), particularly Gram-negative bacteria, poses significant challenges due to their robust outer membranes limiting antibio...