Bipolar Disorder

Classifying Treated vs. Untreated MDD Adolescents from Anatomical Connectivity using Nonlinear SVM.

Identification of the treatment-related responders for adolescent Major Depressive Disorder (MDD) is urgently needed to develop effective treatments. In this paper, machine learning based classifiers are used to reveal anatomical features as responders for distinguishing MDD patients who have received treatment from those who never received any treatment. The features are drawn from two sets of me...

Anatomical Biomarkers for Adolescent Major Depressive Disorder from Diffusion Weighted Imaging using SVM Classifier.

Adolescent Major Depressive Disorder (MDD) is a common and serious mental illness that could lead to tragic outcomes including chronic adult disability and suicide. In this paper, we explore anatomical features and apply machine learning approaches to identify responsive biomarkers distinguishing MDD patients from healthy subjects. The features of interest include metrics in two categories: a) ana...

Depression Severity Classification from Speech Emotion.

Major Depressive Disorder (MDD) is a common psychiatric illness. Automatically classifying depression severity using audio analysis can help clinical ...

A New Local Bipolar Autoassociative Memory Based on External Inputs of Discrete Recurrent Neural Networks With Time Delay.

In this paper, local bipolar auto-associative memories are presented based on discrete recurrent neural networks with a class of gain type activation ...

Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia.

OBJECTIVE: Although hyperprolactinemia carries a long-term risk of morbidity, the threshold of dopamine D2/3 receptor (D2/3R) occupancy for hyperprola...

Antiphospholipid Syndrome with Antiβ2glicoprotein-1 Antibodies as the Cause of Recurrent Tibial Vein Thrombosis in SAPHO syndrome.

The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thrombo...

Simple, rapid and highly sensitive HPLC method for measurement of Lamotrigine in human plasma and its clinical applications.

Spikes in Lamotrigine concentrations levels and associated clinical toxicity may occur unpredictably. This study describes the development and validat...

On Interestingness Measures for Mining Statistically Significant and Novel Clinical Associations from EMRs.

Association rule mining has received significant attention from both the data mining and machine learning communities. While data mining researchers f...

Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats.

Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antid...

Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial.

In this study, the aim was to determine whether adding vitamin D to the standard therapeutic regimen of schizophrenic male patients with inadequate vi...

Electroencephalographic markers of robot-aided therapy in stroke patients for the evaluation of upper limb rehabilitation.

Stroke is the leading cause of permanent disability in developed countries; its effects may include sensory, motor, and cognitive impairment as well a...

Using structural MRI to identify individuals at genetic risk for bipolar disorders: a 2-cohort, machine learning study.

BACKGROUND: Brain imaging is of limited diagnostic use in psychiatry owing to clinical heterogeneity and low sensitivity/specificity of between-group ...

[Research on Early Identification of Bipolar Disorder Based on Multi-layer Perceptron Neural Network].

Multi-layer perceptron (MLP) neural network belongs to multi-layer feedforward neural network, and has the ability and characteristics of high intelli...

Electronic medical records: fast track to big data in bipolar disorder.

A Multi-Relational Model for Depression Relapse in Patients with Bipolar Disorder.

Bipolar Disorder (BD) is a chronic and disabling disease that usually appears around 20 to 30 years old. Patients who suffer with BD may struggle for ...

Semantic Web Ontology and Data Integration: a Case Study in Aiding Psychiatric Drug Repurposing.

There remain significant difficulties selecting probable candidate drugs from existing databases. We describe an ontology-oriented approach to represe...

[Development and validation of a new HPLC method for determination of Lamotrigine and clinical application].

BACKGROUND: Lamotrigine is an effective anticonvulsant drug used in the treatment of epilepsy. It has a narrow therapeutic range, a large inter and in...