BPH/LUTS

Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis.

Adipogenesis is intricately linked to the onset and progression of muscle aging; however, the relevant biomarkers remain unclear. This study sought to identify key genes associated with adipogenesis in the context of muscle aging. Firstly, gene expression profiles from biopsies of the vastus lateralis muscle in both young and elderly population were retrieved from the GEO database. After intersect...

System level network data and models attack cancer drug resistance.

Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small-scale interactomes and signalling network models of drug resistance guide directed drug development. Recently, proteome-wide human interactome and signalling network data have become available, which have been extended by drug-target interact...

Artificial intelligence streamlines scientific discovery of drug-target interactions.

Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug-t...

Evaluating the role of generative AI and color patterns in the dissemination of war imagery and disinformation on social media.

This study explores the evolving role of social media in the spread of misinformation during the Ukraine-Russia conflict, with a focus on how artifici...

A Multi-Class ECG Signal Classifier Using a Binarized Depthwise Separable CNN with the Merged Convolution-Pooling Method.

Binarized convolutional neural networks (bCNNs) are favored for the design of low-storage, low-power cardiac arrhythmia classifiers owing to their hig...

AI for BPH Surgical Decision-Making: Cost Effectiveness and Outcomes.

PURPOSE OF REVIEW: Benign prostatic hyperplasia (BPH) is prevalent in nearly 70% of men over the age of 60, leading to significant clinical challenges...

Mitigating off-target effects of small RNAs: conventional approaches, network theory and artificial intelligence.

Three types of highly promising small RNA therapeutics, namely, small interfering RNAs (siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense o...

The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.

G protein-coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of th...

Evaluation of the Current Status of Artificial Intelligence for Endourology Patient Education: A Blind Comparison of ChatGPT and Google Bard Against Traditional Information Resources.

Artificial intelligence (AI) platforms such as ChatGPT and Bard are increasingly utilized to answer patient health care questions. We present the fir...

Single-port robot-assisted simple prostatectomy: techniques and outcomes.

PURPOSE: To describe the surgical techniques and to analyse the outcomes of single-port robot-assisted simple prostatectomy (SP RASP) procedure for th...

Baseline factors and surgical procedures affecting changes in lower urinary tract symptoms after robot-assisted radical prostatectomy: the impact of nerve-sparing.

PURPOSE: To determine baseline factors and surgical procedures associated with clinically meaningful improvement or deterioration of lower urinary tra...

A robotic approach to clamshell augmentation enterocystoplasty.

Augmentation cystoplasty (AC) is a well-established surgical option for the management of overactive bladder where conservative management has failed....

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project.

OBJECTIVE: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benig...

The application of artificial intelligence to accelerate G protein-coupled receptor drug discovery.

The application of artificial intelligence (AI) approaches to drug discovery for G protein-coupled receptors (GPCRs) is a rapidly expanding area. Arti...

Outcomes of Robotic Simple Prostatectomy After Prior Failed Endoscopic Treatment of Benign Prostatic Hyperplasia.

We compared outcomes of robot-assisted simple prostatectomy (RASP) in patients with and without a history of prior prostate surgery for management of...

Robot-Assisted Simple Prostatectomy: A Comparison of Primary Simple Prostatectomy Salvage Simple Prostatectomy in Treatment of Lower Urinary Tract Symptoms.

Simple prostatectomy is indicated in patients with enlarged glands (>80 ) who present with lower urinary tract symptoms (LUTS) attributed to benign p...

Multimodal convolutional neural networks based on the Raman spectra of serum and clinical features for the early diagnosis of prostate cancer.

We collected surface-enhanced Raman spectroscopy (SERS) data from the serum of 729 patients with prostate cancer or benign prostatic hyperplasia (BPH)...

Differential diagnosis of prostate cancer and benign prostatic hyperplasia based on DCE-MRI using bi-directional CLSTM deep learning and radiomics.

Dynamic contrast-enhanced MRI (DCE-MRI) is routinely included in the prostate MRI protocol for a long time; its role has been questioned. It provides ...

Laparoscopic simple prostatectomy versus robot-assisted simple prostatectomy for large benign prostatic hyperplasia: a systematic review and meta-analysis of comparative trials.

Laparoscopic simple prostatectomy (LSP) and robot-assisted simple prostatectomy (RASP) are important approaches for large benign prostatic hyperplasia...

Robotic versus open simple prostatectomy for benign prostatic hyperplasia in large glands: single-centre study.

PURPOSE: Robot-assisted simple prostatectomy (RASP) for benign prostatic hyperplasia (BPH) is a recently described surgical approach, but comparison w...