Chemotherapy

Potential of SERS and proteomics for biomarker detection in cancer cells.

This study investigates the use of quantitative LC-MS/MS-based proteomics and surface-enhanced Raman...

IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.

Large scale sequencing efforts have defined up to 27 diagnostic entities in B-ALL, leaving few sampl...

Development and validation of a highly accurate multigene gene expression biomarker to predict chemotherapy response in primary triple-negative breast cancer.

PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen and progeste...

Systems-level integration of machine learning, SHAP explainability, PCA, and network topology reveals multitarget protective actions of tannic acid against doxorubicin toxicity in pentose phosphate pathway.

Doxorubicin (DOX) is an effective chemotherapeutic agent; however, its clinical use is limited due t...

Integrating Mechanistic Modeling and Machine Learning to Study CD4+/CD8+ CAR-T Cell Dynamics with Tumor Antigen Regulation.

Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in hematological maligna...

AI-discovered cellular morphometric biomarkers in needle biopsy of prostate cancer predict neoadjuvant androgen deprivation therapy response and enable therapeutic targeting of mTOR in androgen deprivation therapy-resistant tumors.

It is imperative to identify patients with prostate cancer (PCa) who will not benefit from androgen ...

Improving severity grading of chemotherapy-induced myelosuppression in AML via data-driven and model-based deep learning.

Chemotherapy-induced myelosuppression in acute myeloid leukemia (AML) frequently leads to life-threa...

Microneedle-based theranostics for melanoma: Advances and outlook.

Melanoma represents a highly aggressive malignancy that poses persistent challenges for clinical dia...

Mathematical Prediction Models for Sentinel Node Status in Early-Stage Breast Cancer: Protocol for a Systematic Review.

BACKGROUND: The status of the axilla remains a significant prognostic factor and influences adjuvant...

Precision oncology meets nanotechnology: AI-driven liposomal nanocarriers for enhanced cancer immunotherapy.

The integration of artificial intelligence (AI) with nanotechnology is redefining therapeutic strate...

A 13-gene prognostic model developed using machine learning to predict the response to neoadjuvant chemoradiotherapy in rectal carcinoma.

Diagnostic Accuracy of Artificial Intelligence for Predicting MGMT Promoter Methylation in Glioblastoma Using MR Imaging: A Systematic Review.

PURPOSE: Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis. O6-methylguanine-DNA-m...

AI-assisted tumor board decision-making in pancreatic oncology.

BACKGROUND: Pancreatic cancer requires nuanced, multidisciplinary treatment planning typically condu...

Diagnostic accuracy of an AI-based pathologic response assessment in locally advanced non-small cell lung cancer after neoadjuvant chemo-immunotherapy.

Contrasting roles of PD-L1 expression in tumor and stroma: Biological and prognostic implications in esophageal squamous cell carcinoma.

Programmed death-ligand 1 (PD-L1) plays a central role in immune regulation in esophageal squamous c...

MRI-based AI framework for predicting lymph node metastasis and prognosis in rectal cancer after neoadjuvant chemoradiotherapy: a multicenter study.

BACKGROUND: Early prediction of lymph node metastasis (LNM) after neoadjuvant chemoradiotherapy (nCR...

A programmable matrix-robust plasmonic MetaRing biosensor for rapid SERS-based chemotherapeutic response profiling.

Rapid assessment of chemotherapeutic response is essential for precision oncology but remains hinder...

Estimating major pathological response in non-small cell lung cancer patients with post-neoadjuvant therapy using MMT-net.

Neoadjuvant therapy (NAT) has demonstrated considerable effectiveness in treating locally advanced n...

Second-line chemotherapy after gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer: comparative outcomes and AI-guided treatment selection.

BACKGROUND: International guidelines recommend 5FU/LV, Nal-IRI + 5FU/LV, FOLFIRI, FOLFOX, or (m)FOLF...

Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications.

INTRODUCTION: Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss...

Antibody-drug conjugate design and mechanisms of action for cancer treatment: state of the art and beyond.

Antibody-drug conjugates (ADCs) are a leading area of targeted cancer therapeutics, typically combin...