Chemotherapy

Leveraging Digital Twins for Stratification of Patients with Breast Cancer and Treatment Optimization in Geriatric Oncology: Multivariate Clustering Analysis.

BACKGROUND: Defining optimal adjuvant therapeutic strategies for older adult patients with breast cancer remains a challenge, given that this population is often overlooked and underserved in clinical research and decision-making tools.

End-to-end prognostication in pancreatic cancer by multimodal deep learning: a retrospective, multicenter study.

OBJECTIVES: Pancreatic cancer treatment plans involving surgery and/or chemotherapy are highly dependent on disease stage. However, current staging systems are ineffective and poorly correlated with survival outcomes. We investigate how artificial intelligence (AI) can enhance prognostic accuracy in pancreatic cancer by integrating multiple data sources.

Development of Explainable Machine Learning Models to Identify Patients at Risk for 1-Year Mortality and New Distant Metastases Postendoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Secondary Analysis of the PARITY Trial.

BACKGROUND: Accurate prediction of postoperative metastasis and mortality risks in patients undergoing lower-limb oncological resection and endoprosth...

Corrigendum to "Ultrasound-Based Deep Learning Radiomics Nomogram for Tumor and Axillary Lymph Node Status Prediction After Neoadjuvant Chemotherapy" [Academic Radiology 32 (2025) 12-23].

External validation of the Oncotype DX breast cancer recurrence score nomogram and development and validation of a novel machine learning-based model to predict postoperative overall survival and guide adjuvant chemotherapy in ER positive, Her-2 negative breast cancer patients: a retrospective cohort study.

BACKGROUND: This study aims to externally validate the performance of the Oncotype DX (ODX) breast cancer (BC) recurrence score nomogram in predicting...

Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced...

Label-Free and Intelligent Cell Death Recognition Toward Lung Cancer Chemotherapy.

The lack of high-throughput, label-free, and intelligent recognition models for assessing cell death hinders the broad application of cell death analy...

Predicting Treatment Outcomes in Glioblastoma: A Risk Score Model for TMZ Resistance and Immune Checkpoint Inhibition.

Glioblastoma (GBM) presents significant therapeutic challenges due to its invasive nature and resistance to standard chemotherapy, i.e., temozolomide ...

Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

PURPOSE: This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoi...

Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations....

Machine-guided cell-fate engineering.

The creation of induced pluripotent stem cells (iPSCs) has enabled scientists to explore the function, mechanisms, and differentiation processes of ma...

Construction of Sonosensitizer-Drug Co-Assembly Based on Deep Learning Method.

Drug co-assemblies have attracted extensive attention due to their advantages of easy preparation, adjustable performance and drug component co-delive...

Deep learning predicts HER2 status in invasive breast cancer from multimodal ultrasound and MRI.

The preoperative human epidermal growth factor receptor type 2 (HER2) status of breast cancer is typically determined by pathological examination of a...

A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer ...

Dapagliflozin targets the crosstalk between apoptosis, autophagy, and Hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model.

Rheumatoid arthritis is a long-term autoimmune disorder, causes joint capsule, cartilage, and bone damage. Dapagliflozin, a novel antidiabetic drug, d...

Dexmedetomidine versus Magnesium Sulphate in Ultrasound-Guided Bilateral bi-Level Erector Spinae Plane Block in Corrective Scoliosis Surgery: A Randomized Controlled Clinical Trial.

OBJECTIVES: There is a scarcity of research regarding the effects of LAs adjuvant drugs in erector spinae plane block (ESPB), especially in scoliosis ...

Bioassay-guided isolation of a new cytotoxic compound targeting carbonic anhydrase-II: structure-activity relationships and dynamics studies.

Bioassay-guided isolation of A.J. Scott afforded one new natural product (lupeol butyl ether, ), along with sixteen known metabolites (-) reported fr...

Lidocaine exhibits antileishmanial and immunomodulatory activities in an in vitro model of tegumentary leishmaniasis.

Local anesthetics have been shown to inhibit or delay the progression of tegumentary leishmaniasis (TL) in hamster models, although the mechanisms und...

Antibacterial and Antibiofilm Activities of Colistin and Ceftazidime-Avibactam Conjugated Silver Nanoparticles.

Multidrug-resistant (MDR) Gram-negative bacteria constitute a major global health concern, and the increasing resistance to last-line antimicrobial ag...

Development of a Transferable Density-Functional Tight-Binding Model for Organic Molecules at the Water/Platinum Interface.

A computationally efficient and transferable approach for modeling reactions at metal/water interfaces could significantly accelerate our understandin...