Chemotherapy

Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approve...

Machine-guided cell-fate engineering.

The creation of induced pluripotent stem cells (iPSCs) has enabled scientists to explore the functio...

Construction of Sonosensitizer-Drug Co-Assembly Based on Deep Learning Method.

Drug co-assemblies have attracted extensive attention due to their advantages of easy preparation, a...

Deep learning predicts HER2 status in invasive breast cancer from multimodal ultrasound and MRI.

The preoperative human epidermal growth factor receptor type 2 (HER2) status of breast cancer is typ...

A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and...

Dapagliflozin targets the crosstalk between apoptosis, autophagy, and Hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model.

Rheumatoid arthritis is a long-term autoimmune disorder, causes joint capsule, cartilage, and bone d...

Dexmedetomidine versus Magnesium Sulphate in Ultrasound-Guided Bilateral bi-Level Erector Spinae Plane Block in Corrective Scoliosis Surgery: A Randomized Controlled Clinical Trial.

OBJECTIVES: There is a scarcity of research regarding the effects of LAs adjuvant drugs in erector s...

Bioassay-guided isolation of a new cytotoxic compound targeting carbonic anhydrase-II: structure-activity relationships and dynamics studies.

Bioassay-guided isolation of A.J. Scott afforded one new natural product (lupeol butyl ether, ), al...

Lidocaine exhibits antileishmanial and immunomodulatory activities in an in vitro model of tegumentary leishmaniasis.

Local anesthetics have been shown to inhibit or delay the progression of tegumentary leishmaniasis (...

Antibacterial and Antibiofilm Activities of Colistin and Ceftazidime-Avibactam Conjugated Silver Nanoparticles.

Multidrug-resistant (MDR) Gram-negative bacteria constitute a major global health concern, and the i...

Development of a Transferable Density-Functional Tight-Binding Model for Organic Molecules at the Water/Platinum Interface.

A computationally efficient and transferable approach for modeling reactions at metal/water interfac...

Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.

Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East A...

Arylacetamides exhibit antiproliferative effects on non-transformed mammalian and vegetal cells and toxicity on crustaceans and fish embryos.

Non-clinical steps for development, validation and biosafety of new medicines and products comprises...

Promethazine for nausea and vomiting prevention after gynaecological laparoscopic surgery: A randomized controlled trial.

Postoperative nausea and vomiting (PONV) represent significant concerns for patients undergoing surg...

Isolation and characterization of a bioactive compound from Sphingomonas sanguinis DM with cytotoxic and molecular docking analysis.

Datura metel, a common plant in the Solanaceae family, is known for its valuable medicinal propertie...

Interferon gamma-induced hub genes and key pathways: A study based on biological network analysis and experimental validation.

By performing a biological network analysis, we identified some hub genes, which were up- or down-re...

Leafing a mark on immunity: Quercetin-3-O-D-glucopyranoside and quercetin-3-O-(2″,6″-digalloyl)-β-D-galactopyranoside-rich Melia azedarach L. extract's immunoinflammatory effects on an sRBC-immunized BALB/c model.

Melia azedarach L. (Meliaceae) (MA) leaves are traditionally used for inflammatory disorders, yet th...

Correction to "The Melamine-Driven Solvation Effect Promotes Oxygen Reduction on Platinum Catalyst: Machine Learning-Aided Free Energy Calculations".

Stacking classifiers based on integrated machine learning model: fusion of CT radiomics and clinical biomarkers to predict lymph node metastasis in locally advanced gastric cancer patients after neoadjuvant chemotherapy.

BACKGROUND: The early prediction of lymph node positivity (LN+) after neoadjuvant chemotherapy (NAC)...

Identification of Npas4 as a biomarker for CICI by transcriptomics combined with bioinformatics and machine learning approaches.

Chemotherapy is one of the most successful strategies for treating cancer. Unfortunately, up to 70 %...

An efficient patient's response predicting system using multi-scale dilated ensemble network framework with optimization strategy.

The forecasting of a patient's response to radiotherapy and the likelihood of experiencing harmful l...