Congestive Heart Failure

Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease.

Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. Using a novel bioinformatics text-mining tool, we studied six categories of cardiovascular disease (CVD), namely, ischemic heart disease, cardiomyopathies, cerebrovascular accident, congenital heart disease, arrhythm...

Machine learning based brain tumour segmentation on limited data using local texture and abnormality.

Brain tumour segmentation in medical images is a very challenging task due to the large variety in tumour shape, position, appearance, scanning modalities and scanning parameters. Most existing segmentation algorithms use information from four different MRI-sequences, but since this is often not available, there is need for a method able to delineate the different tumour tissues based on a minimal...

Phenotypic Clustering of Left Ventricular Diastolic Function Parameters: Patterns and Prognostic Relevance.

OBJECTIVES: This study sought to explore the natural clustering of echocardiographic variables used for assessing left ventricular (LV) diastolic dysf...

Endocardial linear infarct exclusion technique for non-ischaemic functional mitral regurgitation caused by cardiac sarcoidosis: a case report.

INTRODUCTION: Damage to the posterior wall of the left ventricle (LV) can cause tethering mitral regurgitation (MR). We present a patient with non-isc...

Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.

BACKGROUND: Left ventricular (LV) diastolic dysfunction commonly is observed in individuals with type 2 diabetes mellitus (T2DM). We employed transtho...

Bimodal fuzzy analytic hierarchy process (BFAHP) for coronary heart disease risk assessment.

Rooted deeply in medical multiple criteria decision-making (MCDM), risk assessment is very important especially when applied to the risk of being affe...

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.

Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in ...

A Novel Neural Network Model for Blood Pressure Estimation Using Photoplethesmography without Electrocardiogram.

The prevention, evaluation, and treatment of hypertension have attracted increasing attention in recent years. As photoplethysmography (PPG) technolog...

A novel triterpenoid 16-hydroxy betulinic acid isolated from attributes multi-faced pharmacological activities.

The aerial parts of extensively used ethnomedicinal plant (Burm. f.) Robinson growing wild in Bangladesh were investigated to isolate and characteriz...

Segmentation of Intra-Retinal Cysts From Optical Coherence Tomography Images Using a Fully Convolutional Neural Network Model.

Optical coherence tomography (OCT) is an imaging modality that is used extensively for ophthalmic diagnosis, near-histological visualization, and quan...

Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning.

Traditionally, medical discoveries are made by observing associations, making hypotheses from them and then designing and running experiments to test ...

Regional arterial stiffness in central and peripheral arteries is differentially related to endothelial dysfunction assessed by brachial flow-mediated dilation in metabolic syndrome.

The interrelationship between endothelial function and arterial stiffness may be different for central and peripheral arteries due to their structural...

The Impact of Bronchodilator Therapy on Systolic Heart Failure with Concomitant Mild to Moderate COPD.

In older adults, chronic obstructive pulmonary disease (COPD) is commonly associated with heart failure with reduced ejection fraction (HFrEF), and th...

Regional physiology of ARDS.

The acute respiratory distress (ARDS) lung is usually characterized by a high degree of inhomogeneity. Indeed, the same lung may show a wide spectrum ...

Is There Any Relationship between Plasma 25-Hydroxyvitamin D₃, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

A growing interest in the role of vitamin D in metabolic diseases led us to study the relationships between 25-hydroxyvitamin D₃ (25(OH)D₃) and the pr...

Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells.

Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we dev...

Double hit! A unique case of resistant hypertension.

A middle-aged woman with obesity, hyperlipidaemia and diet-controlled diabetes was referred for resistant hypertension. Her blood pressure (BP) was un...

B-Type Natriuretic Peptide: A Predictor for Mortality, Intensive Care Unit Length of Stay, and Hospital Length of Stay in Patients With Resolving Sepsis.

BACKGROUND: B-type natriuretic peptide (BNP) is a hormone secreted by cardiomyocytes in response to myocardial ischemia, increased ventricular wall te...

Sacubitril/Valsartan in an Elderly Patient with Heart Failure: A Case Report.

Sacubitril/valsartan has recently been approved for the treatment of heart failure with reduced ejection fraction. Given its recent introduction in th...

Effect of Switching from Cilnidipine to Azelnidipine on Cardiac Sympathetic Nerve Function in Patients with Heart Failure Preserved Ejection Fraction.

Cardiac sympathetic nerve activity is known to play a key role in the development and progression of heart failure (HF). Azelnidipine, an L-type calci...