Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Aerodynamic force reconstruction using physics-informed Gaussian processes

Accurate modeling of aerodynamic loads is essential for understanding and predicting the responses o...

Language-dependent diagnostic safety of medical AI systems: a cross-lingual benchmarking and prospective clinical study

Background Patients worldwide receive healthcare in many languages, yet medical AI systems are valid...

Rhythmic temporal structure organizes recurrent dynamics to support sequential working memory

Rhythmic temporal structure improves working memory, but how this benefit emerges from recurrent dyn...

Large Language Model Performance in UK Advice & Guidance: A Pilot Study in Neurology

Background: Large language models (LLMs) demonstrate strong performance in controlled medical enviro...

Clinical Safety of AI-Generated Antibiotic Prescribing Advice: Guideline Adherence and Misinformation Risk Among Large Language Models

Background: Large language models (LLMs) are increasingly used in telehealth, but their safety in an...

Comparison of Machine Learning Surrogate Models for Prediction of Single-Fiber Activation in Deep Brain Stimulation

Machine-learning surrogate models are positioned to help optimize deep brain stimulation (DBS) usage...

CAWI: Copula-Aligned Weight Initialization for Randomized Neural Networks

Randomized neural networks (RdNNs) enable efficient, backpropagation-free training by freezing rando...

Digital Twins as Synthetic Controls in Single-Arm Trials

Single-arm trials are an important study design for evaluating drug efficacy and safety without enro...

BioMADE: Predicting Torsades de Pointes from molecular structures through biologically informed representations

Drug-induced arrhythmias, particularly Torsades de Pointes (TdP), pose a significant risk to patient...

Metis: Learning to Jailbreak LLMs via Self-Evolving Metacognitive Policy Optimization

Red teaming is critical for uncovering vulnerabilities in Large Language Models (LLMs). While automa...

Prompt-engineering improves clinical safety of large language models for opioid equipotency conversion

Background: Large language models (LLMs) are increasingly used in medical education and clinical dec...

Cholinergic modulation of reinforcement learning and prefrontal value computations under uncertainty

The neuromodulator acetylcholine has been suggested to govern learning under uncertainty. Here, we i...

Evaluating Explainability in Safety-Critical ATR Systems: Limitations of Post-Hoc Methods and Paths Toward Robust XAI

Explainable Artificial Intelligence (XAI) is increasingly rec ognized as essential for deploying mac...

Training-Free Probabilistic Time-Series Forecasting with Conformal Seasonal Pools

We propose Conformal Seasonal Pools (CSP), a training-free probabilistic time-series forecaster that...

Safety and accuracy follow different scaling laws in clinical large language models

Clinical LLMs are often scaled by increasing model size, context length, retrieval complexity, or in...

Improving Model Safety by Targeted Error Correction

The widespread adoption of machine learning in critical applications demands techniques to mitigate ...

Compositional Neural-Cyber-Physical System Verification in the Interactive Theorem Prover of Your Choice

Formal verification of neuro-symbolic cyber-physical systems, such as drones, medical devices and ro...

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