Clinical Trials

Can Liposomal Bupivacaine Be Safely Utilized in Elective Spine Surgery?

STUDY DESIGN: Single-blinded prospective randomized control trial.

Application of Pythagorean fuzzy AHP and VIKOR methods in occupational health and safety risk assessment: the case of a gun and rifle barrel external surface oxidation and colouring unit.

The field of occupational health and safety (OHS) focuses on reducing occupational accidents to an acceptable level. OHS covers systematic efforts aimed at providing employee health, safety and welfare in the workplace. This study proposes a new approach for risk assessment in the field of OHS. It integrates the Pythagorean fuzzy analytic hierarchy process (PFAHP) and fuzzy VlseKriterijumska Optim...

Using natural language processing methods to classify use status of dietary supplements in clinical notes.

BACKGROUND: Despite widespread use, the safety of dietary supplements is open to doubt due to the fact that they can interact with prescribed medicati...

Natural Language Processing and Its Implications for the Future of Medication Safety: A Narrative Review of Recent Advances and Challenges.

The safety of medication use has been a priority in the United States since the late 1930s. Recently, it has gained prominence due to the increasing a...

The Effects of Hydration Status on Cognitive Performances among Young Adults in Hebei, China: A Randomized Controlled Trial (RCT).

: Dehydration may affect cognitive performances as water accounts for 75% of brain mass. The purpose of this study is to investigate the effects of de...

Proactive expert system intervention to prevent or quit at-risk alcohol use (PRINT): study protocol of a randomized controlled trial.

BACKGROUND: The population impact of alcohol screening and brief intervention might be increased by approaching an entire population rather than indiv...

Modeling the covariates effects on the hazard function by piecewise exponential artificial neural networks: an application to a controlled clinical trial on renal carcinoma.

BACKGROUND: In exploring the time course of a disease to support or generate biological hypotheses, the shape of the hazard function provides relevant...

Discovery of quality control markers from traditional Chinese medicines by fingerprint-efficacy modeling: Current status and future perspectives.

Quality control (QC) is crucial for ensuring the safety and effectiveness of traditional Chinese medicines (TCMs). Due to extremely complicated phytoc...

Factors influencing unsafe behaviors: A supervised learning approach.

Despite its potential, the use of machine learning in safety studies had been limited. Considering machine learning's advantage in predictive accuracy...

Information-Based Medicine in Glioma Patients: A Clinical Perspective.

Glioma constitutes the most common type of primary brain tumor with a dismal survival, often measured in terms of months or years. The thin line betwe...

Using the MEDiPORT humanoid robot to reduce procedural pain and distress in children with cancer: A pilot randomized controlled trial.

BACKGROUND: Subcutaneous port needle insertions are painful and distressing for children with cancer. The interactive MEDiPORT robot has been programm...

Detraining effects of regular Tai Chi exercise on postural control ability in older women: A randomized controlled trial.

BACKGROUND/OBJECTIVE: This study aimed to investigate the training and detraining effects of Tai Chi (TC) on postural control ability in single leg st...

Augmented outcome-weighted learning for estimating optimal dynamic treatment regimens.

Dynamic treatment regimens (DTRs) are sequential treatment decisions tailored by patient's evolving features and intermediate outcomes at each treatme...

Optimal two-stage dynamic treatment regimes from a classification perspective with censored survival data.

Clinicians often make multiple treatment decisions at key points over the course of a patient's disease. A dynamic treatment regime is a sequence of d...

Connecting Technological Innovation in Artificial Intelligence to Real-world Medical Practice through Rigorous Clinical Validation: What Peer-reviewed Medical Journals Could Do.

Artificial intelligence (AI) is projected to substantially influence clinical practice in the foreseeable future. However, despite the excitement arou...

Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging.

Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on th...

3D Randomized Connection Network with Graph-based Label Inference.

In this paper, a novel 3D deep learning network is proposed for brain MR image segmentation with randomized connection, which can decrease the depende...

Evaluation of an ontology-based system for computerized cognitive rehabilitation.

OBJECTIVES: This paper describes the results of a randomized clinical trial about the effectiveness of a computerized rehabilitation treatment on a sa...

Does Cognitive Impairment and Agitation in Dementia Influence Intervention Effectiveness? Findings From a Cluster-Randomized-Controlled Trial With the Therapeutic Robot, PARO.

OBJECTIVES: To explore whether severity of cognitive impairment and agitation of older people with dementia predict outcomes in engagement, mood state...

Bone mineral density in midlife long-term users of hormonal contraception in South Africa: relationship with obesity and menopausal status.

BACKGROUND: In South Africa, hormonal contraception is widely used in women over the age of 40 years. One of these methods and the most commonly used ...