Clinical Trials

A comparative phase III clinical study to evaluate efficacy and safety of TrastuRel™ (biosimilar trastuzumab) and innovator trastuzumab in patients with metastatic human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer.

INTRODUCTION: The present study for biosimilar trastuzumab was a multicentric, randomized, two-arm p...

A Double-Blind Randomized Clinical Trial Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated ICU Patients.

BACKGROUND: In critically ill patients, enteral feeding through the nasogastric tube is the method o...

A case series of the safety and efficacy of testosterone replacement therapy in renal failure and kidney transplant patients.

BACKGROUND: Hypogonadism is common in patients with renal dysfunction and does not always correct fo...

Relevance of angiopoietin-2 and soluble P-selectin levels in patients with pulmonary arterial hypertension receiving combination therapy with oral treprostinil: a FREEDOM-C2 biomarker substudy.

UNLABELLED: Studies have suggested roles for angiopoietin-2 (Ang-2) and soluble P-selectin (sP-selec...

The Effects of First-Line Anti-Tuberculosis Drugs on the Actions of Vitamin D in Human Macrophages.

Tuberculosis (TB) is a major global health problem. Patients with TB have a high rate of vitamin D d...

Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.

OBJECTIVES: We tested the hypothesis that oral progesterone administration attenuates drug-induced Q...

[Analysis of Diemailing Kudiezi injection use in real world in 7 189 patients with cerebral infarction].

This is a study based on hospital intensive monitoring to explore medication use of Diemailing Kudie...

30 Years of Robotic Surgery.

The idea of reproducing himself with the use of a mechanical robot structure has been in man's imagi...

[Safety and Tolerance of Healthy People to Injection of Astragalosides-a New Drug for Coronary Heart Disease].

OBJECTIVES: To assess the safety and tolerance of healthy volunteers to as tragalosides injection (A...

Assistive Device for Efficient Intravitreal Injections.

Intravitreal therapy is the most common treatment for many chronic ophthalmic diseases, such as age-...

Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions.

HIV-1 vaccine injection has been shown less effective due to the diversity of antigens. Increasing t...

Re: Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: A Randomized Clinical Trial.

Conflicting results of robot-assisted versus usual gait training during postacute rehabilitation of stroke patients: a randomized clinical trial.

Robot gait training has the potential to increase the effectiveness of walking therapy. Clinical out...

Robotic versus Laparoscopic Gastrectomy for Gastric Carcinoma: a Meta-Analysis of Efficacy and Safety.

PURPOSE: To systematically review efficacyand safety of robotic gastrectomy (RG) compared with conve...

Alpha-Linolenic Acid-Enriched Diacylglycerol Oil Suppresses the Postprandial Serum Triglyceride Level-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

This study investigated the effect of a single oral ingestion of alpha-linolenic acid-enriched diacy...

Effect of Borago Officinalis Extract on Moderate Persistent Asthma: A Phase two Randomized, Double Blind, Placebo-Controlled Clinical Trial.

BACKGROUND: Borago officinalis and its derivatives are used in folk medicine to treat asthma because...

Effectiveness of Vitamin D Supplement Therapy in Chronic Stable Schizophrenic Male Patients: A Randomized Controlled Trial.

In this study, the aim was to determine whether adding vitamin D to the standard therapeutic regimen...

A Retrospective Study to Evaluate Use of Negative Pressure Wound Therapy in Patients Undergoing Bilateral Internal Thoracic Artery Grafting.

Bilateral internal thoracic artery (BITA) grafting may be associated with a higher risk of postopera...

Radial artery blood gas sampling: a randomized controlled trial of lidocaine local anesthesia.

BACKGROUND: Radial artery puncture is a common procedure and yet the role of local anesthesia for re...

[The Safety and Feasibility of Conversion Surgery for Initially Unresectable Pancreatic Cancer].

BACKGROUND: By remarkable progress of chemotherapy for pancreatic cancer, we sometimes achieve resec...

[Constipation predominant irritable bowel syndrome treated with acupuncture for regulating the mind and strengthening the spleen: a randomized controlled trial].

OBJECTIVE: To observe the clinical efficacy on constipation predominant irritable bowel syndrome (IB...