Clinical Trials

Beyond technological affordances: Trust and continued intention to use AI-enabled recruitment systems across neurodivergent and neurotypical applicants.

This study examines how technological affordances shape applicants' continued intention to use AI-enabled recruitment systems, with particular attention to differences between neurodivergent and neurotypical applicants. Grounded in the Elaboration Likelihood Model, the study investigates association, editability, persistence, and anonymity as evaluative cues and examines the role of trust in appli...

Current Advances and Navigating the Complexities of SVG-PCI.

Saphenous vein graft (SVG) percutaneous coronary intervention (PCI) remains technically challenging and clinically high risk due to the friable, thrombus-rich nature of SVG lesions, which predispose to distal embolization, no-reflow, and periprocedural myocardial infarction (MI). The role of embolic protection devices in contemporary practice remains unclear. Although early randomized trials demon...

Head and Neck Free Flap Reconstruction: Current Landscape and Emerging Technologies.

OBJECTIVE: To synthesize contemporary developments in head and neck oncologic free flap reconstruction, with emphasis on perioperative physiologic opt...

Medicinal Chemistry Perspectives on Drug Repurposing: Innovative Approaches and Therapeutic Breakthrough.

Drug repurposing involves the discovery of new therapeutic uses of existing drugs that have already been approved by the regulatory authorities. It pr...

Efficacy evaluation of artificial intelligence in radiological imaging diagnosis based on randomized controlled trials: a scoping review.

OBJECTIVE: Artificial intelligence (AI) demonstrates significant potential in medical imaging diagnosis, yet its real-world clinical value requires va...

Precision Transfusion Medicine in the Omics Era.

Transfusion medicine has practiced a form of precision medicine for decades through compatibility testing, infectious disease screening, component man...

Artificial Intelligence-Assisted Screening for Patients With Diabetic Retinopathy and Age-Related Macular Degeneration in Family Medicine and Geriatric and Gerontology Care: Protocol for a Pragmatic Randomized Clinical Trial.

BACKGROUND: Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are 2 of the leading causes of vision loss worldwide. As population a...

Generative Artificial Intelligence Literacy Scale for Nurses: Development and Psychometric Evaluation.

BACKGROUND: Generative artificial intelligence (GenAI) can automate time-intensive tasks and support clinical decision-making in care settings. Nurses...

Securing Safety and Quality in AI-generated Patient Education: A Nurse-led Methodological Framework Integrating Kolcaba's Comfort Theory.

Generative artificial intelligence offers personalized patient education, yet clinical inaccuracy and lack of theoretical grounding threaten health ca...

The reliability-clarity paradox in vascular digital health: A nurse-led evaluation of ChatGPT-4's accuracy in diabetic foot ulcer management.

BACKGROUND: Diabetic foot ulcers remain a leading cause of non-traumatic amputations worldwide, necessitating precise patient education and clinical m...

Microbiota-gut-brain axis in autism spectrum disorder: integrating brain structure, function, and transcriptomics.

Growing evidence indicates that disruption of the microbiota-gut-brain (MGB) axis is a key factor in autism spectrum disorder (ASD), affecting neurode...

Why Next-generation mechanistic models Will transform drug discovery: integrating efficacy and safety.

INTRODUCTION: Drug discovery remains constrained by high attrition rates and the fragmented evaluation of exposure, efficacy, and safety. Mechanistic ...

Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Cultural and linguistic tailoring for a digital health intervention.

Chronic pain (CP) disproportionately affects underserved populations who often experience barriers to evidence-based nonpharmacologic treatments. Digi...

Medical students' use of large language models: a national survey.

BACKGROUND: Large language models (LLMs) are increasingly embedded in medical education and clinical care settings, yet contemporary Canadian data des...

Alleviating Nurse Burnout With an Artificial Intelligence-Selected Mobile Cognitive Behavioral Therapy-Based Intervention: Mixed Methods Randomized Controlled Trial.

BACKGROUND: Nurse burnout is a pervasive global problem. Cognitive behavioral therapy (CBT) has been shown to reduce burnout; however, most digital CB...

Real-Time Smartphone Monitoring Assessments as a Cognitive Biomarker of Alzheimer Disease: Protocol for a Development Study.

BACKGROUND: The diagnosis and monitoring of Alzheimer disease (AD) currently rely on clinician-administered, in-person, and cross-sectional pen-and-pa...

Evaluation and Comparison of Latent Health Risk Prediction Models for Clinical Triage: Protocol for a Mixed Methods Study.

BACKGROUND: Clinical triage requires integrating multiple information sources to identify patients at risk of deterioration. Tools capturing global he...

A randomized controlled trial evaluating the use of an intelligent, fully automated 2D imaging system to detect lame cows and control lameness.

A fully automated 2-dimensional imaging system that uses machine learning to produce real-time mobility scores has been developed and previously exter...

Can Consumers Rely on AI Chatbots for Food Safety Advice? A Comparative Analysis of Chatbot Responses and Food Safety Specialists' Guidance.

The growing integration of artificial intelligence tools, particularly conversational agents, is transforming how consumers access information, includ...

Artificial Intelligence-Mediated Discharge Document for Accessible Health Care (AIM-HEALTH): Protocol for a Prospective, Observational, Noninterventional Study.

BACKGROUND: Hospital discharge reports (HDRs) support continuity of care; yet, their specialized terminology may hinder patient understanding and post...