Clinical Trials

Reinventing miRNA cancer therapy through immunomodulation and AI.

Despite the rational therapeutic premise of microRNA (miRNA) replacement or inhibition for cancer treatment, its clinical translation remains significantly constrained. Major challenges span from inherent molecular instability and off-target effects to substantial delivery hurdles. This persistent translational impasse continues despite continuous advancements in oligonucleotide chemistry and deli...

Intelligent virtual agents in psychotherapy: a safety evaluation across high-risk mental health scenarios.

The growing burden of mental illness and limited access to evidence-based psychotherapy have increased interest in artificial intelligence (AI)-driven conversational agents as potential supports for mental health care. In this exploratory pilot study, we examined the safety and feasibility of an intelligent virtual agent (IVA) designed to simulate psychotherapeutic interactions, with a focus on hi...

Tech That Scales: A Practical Framework for Artificial Intelligence-Enabled Cancer Care in Low- and Middle-Income Countries and Underserved US Counties.

Cancer outcomes remain starkly unequal: 5-year survival rates for common malignancies in low- and middle-income countries (LMICs) often lag 20-40 perc...

Artificial Intelligence in Minimally Invasive Gynecological Surgery: A Systematic Review of Task- Specific Performance and Clinical Translational Readiness.

OBJECTIVE: To systematically evaluate the task-specific performance and clinical translational readiness of artificial intelligence (AI) applications ...

A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.

BACKGROUND: Highly accessible and scalable, digital mental health interventions can reduce barriers associated with traditional treatment. Woebot for ...

First step towards predicting clinical immunogenicity of biologics using in vitro based readouts as animal trial alternatives.

Immunogenicity risk assessment is a critical step in the therapeutic development process of biologics. However, anti-drug antibodies continue to occur...

Examining interactive AI-supported learning environments: The mediating role of AI metacognition and the moderating role of cognitive flexibility.

As generative artificial intelligence (GenAI) becomes increasingly integrated into educational contexts, learners' interactions with AI systems have e...

Present and Future Post-marketing Drug Safety Assessment in Japan: A PMDA Perspective.

For pharmacovigilance, the Pharmaceuticals and Medical Devices Agency in Japan has utilized real world data (RWD) from multiple sources, including ind...

Automated estimation of drain output in postoperative patients using deep learning on clinical images.

Postoperative drains are essential components of care in general surgery and intensive care units, where accurate monitoring of drain output is critic...

Unpacking the dual psychological paths of employee-AI collaboration on creativity: The role of proactive behavior.

The deep integration of artificial intelligence (AI) into organizational settings has significantly transformed employees' work patterns, underscoring...

The ABCD of AI-Enabled Clinical Reasoning: A Guided Framework to Transform Learner Interactions and Decision Quality.

OBJECTIVE: To evaluate the efficacy of a structured guidance framework articulate, brainstorm and benchmark, critique and customize, and decide and di...

AI-driven navigated hematoma aspiration vs. conservative treatment for spontaneous intracerebral hemorrhage: study protocol for a randomized controlled trial.

BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) remains one of the most devastating types of stroke, with high mortality and long-term disabili...

Smart PPE and wearable technology for construction safety management: A scientometric analysis and state-of-the-art review.

This study presents a scientometric and state-of-the-art review of smart personal protective equipment (PPE) and wearable safety technologies (WSTs) i...

Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial.

BACKGROUND: Given the increasing prevalence of depression and anxiety disorders and enduring barriers to care, there is a critical need for alternativ...

'Real time, real change': the role of artificial intelligence in providing real-time language translation services in regional medicine.

Artificial intelligence (AI) is rapidly evolving worldwide, enabling greater flexibility and applicability to the field of language translation within...

DeepFAN, a transformer-based model for human-artificial intelligence collaborative assessment of incidental pulmonary nodules in CT scans: a multireader, multicase trial.

The widespread adoption of computed tomography has increased the detection of lung nodules. However, deep learning methods for classification of benig...

The future of pediatric airway management.

PURPOSE OF REVIEW: This review examines recent advances in pediatric airway management, including emerging technologies, updated guidelines, and innov...

Online surveys, a breakthrough in research, especially in nutrition and food sciences.

BACKGROUND: Technological advancements and widespread internet connectivity have fundamentally transformed data collection across academic disciplines...

Modeling Diabetes Risk and Progression With Public Health Data: Ontology-Guided, Simulation-Capable Digital Twin Study.

BACKGROUND: Digital twins (DTs) offer a paradigm for health care by enabling data-driven, simulation-capable representations of individual health traj...

Use of AI to Predict and Support Medication Adherence in Patients With Breast Cancer: Systematic Review.

BACKGROUND: Oral medications are commonly used in the treatment of breast cancer (BC), despite high rates of nonadherence. As adherence is fundamental...