Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Advancing Global Drug Safety: Challenges and Future Perspectives in Pharmacovigilance.

Adverse Drug Reactions (ADRs) pose significant challenges to patient safety, healthcare systems, and public health worldwide. As the pharmaceutical landscape expands with complex therapies such as biologics and biosimilars, the need for robust pharmacovigilance systems has become paramount. This review provides a comprehensive overview of ADRs, their classification, underlying mechanisms, and asso...

Mar 12 2026 41832691

Language-Related Functional Connectivity in Post-Stroke Aphasia: Preliminary Findings from a Graph-Theoretical and Interpretable Machine Learning Study.

PURPOSE: To have an insight into language-related functional connectivity in post-stroke aphasia (PSA) from graph theory measurements when performing an ability-matched auditory-verbal task fMRI. METHODS: Fifty-seven PSA patients were stratified into high-level (n = 22) and low-level (n = 35) groups using an ability-matched auditory-verbal fMRI paradigm. Functional connectivity was modeled via ROI...

Mar 12 2026 41820794
Advancing cell and gene therapy: Application of AI/ML in clinical development and patient management.

This article explores the transformative potential of artificial intelligence (AI) and machine learning (ML) in advancing cell and gene therapy (CGT) ...

Mar 12 2026 41814849
Trustworthy AI-Augmented Objective Structured Clinical Examinations in Nursing Education: Taiwan-Japan Viewpoint on 5 AI Roles, Governance, and Cross-Border Implementation.

Generative artificial intelligence (AI) is arriving in high-stakes assessment; however, governance, validity evidence, and faculty readiness remain un...

Mar 12 2026 41818744
Strategic Governance of Artificial Intelligence-Enabled Clinical Algorithm Development: Formative Evaluation of the Semiautomatic Clinical Algorithm Development Framework.

BACKGROUND: Health care leaders face a strategic dilemma: traditional expert-led content development ensures safety but is too slow for digital innova...

Mar 12 2026 41818751
Multimodal MRI radiomics for predicting HIFU ablation efficacy in uterine fibroids: a machine learning study.

OBJECTIVE: To explore the predictive value of machine learning-based multimodal MRI radiomics combined with clinical features in the efficacy of high-...

Mar 11 2026 41813595
NeuroMix-DL: Improving imaging quality of a fast multiparametric MRI protocol using deep learning.

PURPOSE: To improve the quality of a fast multi-contrast MR protocol acquisition using deep learning. MATERIALS AND METHODS: 350 patients (age: 64 ± 1...

Mar 11 2026 41831364
A machine learning based scheme for enhancing the detection of position falsification attacks in vehicular ad hoc networks.

Vehicular Ad Hoc Networks (VANETs) are wireless networks established between vehicles and their surrounding infrastructure, enabling the exchange of i...

Mar 11 2026 41813742
Advanced Prompting Techniques Informed by Clinical Expertise Improve the Accuracy of LLM Data Extraction but Increase Non-Determinism.

Prompt engineering techniques which aid in the use of generative artificial intelligence to address classification tasks have expanded considerably in...

Mar 11 2026 41814072
Analysis of the effects of individual characteristics, safety training and awareness of dockers on occupational accidents using accident causality models.

Objectives. This research aims to provide information on factors that may affect the accident susceptibility of workers by using various individual ch...

Mar 11 2026 41812076
Mortality score in chronic coronary syndrome: prediction model from the ISCHEMIA trial.

AIMS: Accurate stratification of mortality risk is essential for management of chronic coronary syndromes (CCS), but existing models focus primarily o...

Mar 11 2026 41812133
AI-Enhanced Conversational Agents for Personalized Asthma Support in People With Asthma: Factors for Engagement, Value, and Efficacy in a Cross-Sectional Survey Study.

BACKGROUND: Asthma-related deaths in the United Kingdom are the highest in Europe, and only 30% of patients access basic care. There is a need for alt...

Mar 11 2026 41812152
Diagnostic, predictive, and therapeutic approaches for impacted canines: a systematic review and meta-analysis.

OBJECTIVE: Maxillary canine impaction affects approximately 1-3% of the population and presents diagnostic, prognostic, and therapeutic challenges. Th...

Mar 10 2026 41807950
A deep reinforcement learning algorithm for optimizing safety and efficiency of traffic signals using traffic conflict technique and artificial intelligence-based video analytics.

The advancements in computer vision have opened doors to estimate crash risks in real-time and revisit traffic signal systems to optimize safety and e...

Mar 10 2026 41812491
Artificial Intelligence Models for Predicting Triage in Emergency Departments: Seven-Month Retrospective Comparative Study of Natural Language Processing, Large Language Model, and Joint Embedding Predictive Architectures.

BACKGROUND: Triage errors in emergency departments (EDs), including undertriage and overtriage, pose significant risks to patient safety and resource ...

Mar 10 2026 41805589
Florida golf cart crashes (2011-2021): a statewide analysis of crash patterns and predictors.

OBJECTIVE: Golf carts are increasingly sharing public roads with other vehicles, creating new safety challenges due to their design limitations and ga...

Mar 10 2026 41805591
Clinical implementation of AI for vertebral fracture detection in CT aligned with fracture liaison services: high prevalence of undiagnosed vertebral fractures.

UNLABELLED: We assessed feasibility and effectiveness of AI-based VF screening in CT, integrated with a local FLS. The system identified VFs in 14% of...

Mar 10 2026 41805842
AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

BACKGROUND: Ferroptosis plays a critical role in immune regulation and tumor microenvironment remodeling. However, its therapeutic potential in enhanc...

Mar 10 2026 41807033
Evaluating Large Language Models-Generated Health Education Materials for Discharged Patients with Diabetes: A Comparative Analysis.

BACKGROUND: Diabetes is a chronic condition requiring long-term management, and continuous health education is vital for improving disease awareness a...

Mar 10 2026 41807129
[Discovery of multi-omics-based biomarkers for immune-related adverse events: precision management with 3D-SPACE].

This article provides a systematic review of the advances in the precise diagnosis and management of immune-related adverse events (irAEs) induced by ...

Mar 10 2026 41796001
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