Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Survival and Surrogate Biomarkers in Interventional Oncology Trials: Pitfalls, Challenges, and Future Directions.

INTRODUCTION: Interventional oncology (IO) is a key component of multidisciplinary cancer care, delivering minimally invasive therapies with safety and efficacy comparable to or surpassing conventional approaches. As IO enters a transformative era, the field must continue demonstrating value within the greater world of oncology, particularly through the study and application of surrogate endpoints...

Jan 16 2026 41545771

Atrial Fibrillation Ablation Using 3D Artificial Intelligence Module Integration with Intracardiac Echocardiography.

BACKGROUND: Intracardiac echocardiography (ICE)-based electroanatomical mapping (EAM) improves procedural efficiency and safety in atrial fibrillation (AF) ablation and remains the standard of care. The CARTOSOUND FAM (AI FAM) module uses a deep-learning algorithm that automates left atrial reconstruction without manual contouring. OBJECTIVE: This study aims to evaluate the one-year outcomes of AI...

Jan 16 2026 41546622
A study of the effect of AI usage on students' self-efficacy and academic performance in business education: Moderating effect of teacher support [Registered report - stage I].

The integration of artificial intelligence (AI) in business education marks a significant shift in pedagogical approaches, yet the psychological mecha...

Jan 16 2026 41547280
Computer Aided Polyp Detection Multi-center International Randomized Controlled Study with a Focus on Community Clinics: GAIN Clinical Trial.

BACKGROUND/AIMS: Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at a...

Jan 16 2026 41548723
Construction of a classification system for long-term care service needs among the elderly based on cluster analysis and machine learning: A multi-center, cross-sectional study in central China.

BACKGROUND: Rapid global aging has led to an increasing demand for long-term care services for the elderly; however, current long-term care systems ar...

Jan 15 2026 41619455
Shape matters: Predicting Huntington's disease using progression modelling.

BACKGROUND: Despite evidence of group-level differences in striatal morphometry among persons with Huntington's Disease (PwHD), current models of HD p...

Jan 15 2026 41564629
Ethnic fermentation secrets of Northeast India and emerging functional food insights.

Northeast India is home to an incredible variety of ethnic fermented foods, shaped over centuries by cultural wisdom and adaptation to the local envir...

Jan 15 2026 41703880
Comparable Outcomes in Pediatric and Adult Patients With Sudden Sensorineural Hearing Loss.

OBJECTIVE: To identify prognostic factors for unilateral idiopathic sudden sensorineural hearing loss (SSNHL) in pediatric and adult patients, and to ...

Jan 15 2026 41537280
Limitations in the Design of Critical Care Studies and Suggestions for Future Research Directions.

Glucocorticoid (GC) therapy has been a cornerstone of critical care; however, its full potential has been constrained by fixed-dose regimens and trial...

Jan 15 2026 41539328
Increasing engagement with cognitive-behavioral therapy (CBT) using generative AI: a randomized controlled trial (RCT).

BACKGROUND: Shortages in mental healthcare lead to long periods of inadequate support for many patients. While digital interventions offer a scalable ...

Jan 15 2026 41540194
ChatGPT-guided translation of pediatric emergency department discharge instructions.

BACKGROUND: Language barriers in pediatric emergency medicine discharge instructions can impact patient safety, leading to poorer post-discharge outco...

Jan 14 2026 41533280
Nalmefene and naltrexone reduce alcohol intake via selective efficacy in subpopulations distinguished by behavioral and blood-based biomarkers.

BACKGROUND: The relative efficacies of nalmefene versus naltrexone for alcohol use disorder is the subject of intense and ongoing debate. The two pan-...

Jan 14 2026 41535481
Gut dysbiosis in oncology: a risk factor for immunoresistance.

The gut microbiome is recognized as a determinant of response to immune checkpoint inhibitor (ICI) therapies in cancer. However, the clinical translat...

Jan 14 2026 41535719
Assessment of AI-generated responses to common pregnancy questions: A blinded expert evaluation.

INTRODUCTION: We conducted a cross-sectional, blinded expert evaluation of AI-generated answers to 22 frequently asked pregnancy questions to characte...

Jan 14 2026 41539048
The effectiveness of AI-based conversational agents in nursing education: A systematic review.

AIM: Comprehensive evaluation of randomized and non-randomized controlled trials (RCTs and NRCTs, respectively) on the effectiveness of AI-driven conv...

Jan 14 2026 41547257
Initial diagnosis and management of acute ischemic stroke: recent update and future direction.

Acute ischemic stroke (AIS) outcomes depend critically on rapid, accurate early diagnosis in the emergency department. Traditional prehospital tools a...

Jan 14 2026 41554281
Randomized evidence on AI-enabled personalized treatment planning for adults with depressive-anxiety Spectrum disorders: A systematic review and Meta-analysis.

BACKGROUND: AI-enabled personalized treatment planning may improve outcomes by tailoring care, yet its clinical impact across modalities remains uncer...

Jan 13 2026 41539612
Stem Cell-Derived Organoids as a Next-Generation Platform for Drug Toxicity and Efficacy Testing: Toward Replacing Animal Models in Regulatory Science.

Three-dimensional, self-organizing structures derived from stem cells, known as organoids, represent a groundbreaking advancement in preclinical drug ...

Jan 13 2026 41527526
The gut microbiota dysbiosis in geriatric multimorbidity: Pharmacotherapeutic implications, pathophysiological mechanisms, and precision modulation strategies.

Aging around the world is accelerating. With that comes the intersection of geriatric multimorbidity and polypharmacy, creating a large uncertainty ab...

Jan 13 2026 41539609
Nano-AI synergy in food chemistry: smart analytical tools for quality, safety, and nutritional profiling.

The convergence of nanotechnology and artificial intelligence (AI) is revolutionizing the landscape of food chemistry, quality control, and nutritiona...

Jan 13 2026 41544475
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