Clinical Trials

A comprehensive analysis of occupational health and safety risks in civil aviation cargo: Insights from FF-DEMATEL.

BackgroundCivil aviation cargo operations have expanded rapidly, but the occupational health and safety risks faced by cargo workers are still rarely examined through an integrated causal framework that captures chemical, ergonomic, psychosocial, and operational exposures together.ObjectiveThis study aims to identify, prioritize, and interpret the causal relationships among occupational health and...

Clinical applications of artificial intelligence in autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder leading to kidney failure. Recent advancements in artificial intelligence (AI) are transforming the diagnosis, risk stratification, management and prognostication in ADPKD by enabling more accurate assessments and individualized care. AI-powered imaging tools enhance the measurement of total kidney volu...

Innovations in Crisis Line Interventions.

Background: Crisis lines provide evidence-based suicide prevention support that often involves active listening, safety assessment, collaborative prob...

Turning AI hallucinations into scaffolds for morphologic reasoning: A pilot randomized trial of prompt-guided virtual microscopy learning during a focused histology module.

AI is a medical education tool, yet its potential to foster morphologic reasoning remains underexplored. Histology students often struggle to move bey...

A Review of Failure Modes and Safety Strategies of Lithium-Ion Batteries from Materials to Systems.

Lithium-ion batteries (LIBs) have rapidly proliferated due to their high energy density, fast charging capability, and long cycle life. However, intri...

Esketamine multi-omic biomarker evaluation in major depressive disorder (EMBER-MDD): concept, objectives and methodologies of a non-clinical investigator-initiated study.

Treatment resistance (TR) in major depressive disorder (MDD) affects a substantial minority of patients and is hard to recognize early, delaying inten...

Use of a Conversational Agent for Training Mental Health Professionals in Suicide Safety Planning: Pilot Feasibility and Acceptability Study.

BACKGROUND: Safety planning is recognized as one of the most effective interventions for reducing suicidal behaviors. The quality of safety plans stro...

Iterative Multidisciplinary Development and Evaluation of a Patient-Facing SDoH Chatbot Using Synthetic Data Simulation.

BACKGROUND: Systematic collection of social determinants of health (SDoH) data remains inconsistent across healthcare settings, despite its critical i...

Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis.

BACKGROUND: Depression is a prevalent mental health disorder and a leading cause of disability worldwide, creating substantial personal and societal b...

Teaching AI ethics in medical schools: a scoping review protocol on the ethical-technical balance in curricular frameworks.

INTRODUCTION: The rapid integration of artificial intelligence (AI) technologies in healthcare, ranging from diagnostic tools to clinical decision sup...

Clinical artificial intelligence (AI) in Japan: Regulatory pathways, domain-specific evidence, and its data infrastructure from an international perspective.

Artificial intelligence (AI) has advanced rapidly across clinical domains, generating both a growing evidence base and dedicated regulatory frameworks...

A two-stage SEM-ANN analysis of digital attitude, cognitive engagement, and digital self-efficacy as determinants of learning effectiveness in the AI era.

Although the rapid advancement of Artificial Intelligence (AI) has a great impact on education, students' learning effectiveness is still the ultimate...

AI Chatbot Suicide Risk Detection and Response: Human Validation Study of the Open-Source VERA-MH Safety Evaluation.

BACKGROUND: Millions of people now use leading generative artificial intelligence (AI) tools (chatbots) for psychological support. Despite the promise...

Effect of artificial intelligence on nursing documentation and patient safety.

Nursing documentation is a fundamental component of safe clinical practice, supporting effective communication, continuity of care and patient safety....

The effectiveness of a plant-based milk with fermented brown rice on constipation symptoms via gut microbiota modulation: a double-blind randomized controlled trial.

PURPOSE: To evaluate the effects of a plant-based milk with fermented brown rice on constipation symptoms in patients with functional constipation and...

Leveraging Real-World Data for Clinical Decision Making in Geriatric Oncology.

Older adults represent most patients with cancer worldwide, yet they remain substantially underrepresented in randomized clinical trials (RCTs), limit...

Comparative Outcomes of a Pediatric Walking Rehabilitation Robot Combined With Repetitive Transcranial Magnetic Stimulation in Children With Spastic Cerebral Palsy: Protocol for a Prospective Observational Study.

BACKGROUND: Cerebral palsy (CP) is a prevalent neurodevelopmental disorder in children, often leading to long-term motor impairments. Rehabilitation r...

Evaluation of a Digital Intervention for Monitoring and Improving Medication Adherence Among Real-World e-Consumers of HIV Preexposure Prophylaxis in China: Protocol for a Randomized Controlled Trial.

BACKGROUND: Preexposure prophylaxis (PrEP) is a key biomedical HIV prevention strategy that relies heavily on adherence for optimal effectiveness. In ...

Effects of Telerehabilitation Based on Motion Recognition Technology on Exercise Endurance of Patients With Non-Small Cell Lung Cancer After Surgery: Single-Center, Prospective, Open-Label, Randomized Controlled Trial.

BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 85% of primary pulmonary neoplasms. Complete surgical removal remains the co...

Is Nonpapillary Puncture a Feasible Alternative to Papillary Access in Percutaneous Nephrolithotomy? A Systematic Review and Meta-Analysis.

PURPOSE: Percutaneous nephrolithotomy (PCNL) is the gold standard for treating large and complex renal calculi, but puncture path selection (papillary...