Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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Engineering extracellular vesicles for targeted siRNA delivery: Advances, therapeutic applications, and clinical translation.

Small interfering RNA (siRNA) therapeutics have emerged as a transformative approach for sequence-specific gene silencing, offering the potential to treat a broad spectrum of diseases by selectively suppressing disease-associated genes. However, the clinical translation of siRNA remains limited by rapid enzymatic degradation, poor cellular uptake, inadequate endosomal escape, and off-target effect...

Sep 5 2026 42700828

Application of Emerging Technologies in the Antiviral Field.

Viral diseases pose a serious threat to global public health, agriculture, and biosecurity. Conventional antiviral strategies are often limited by an incomplete understanding of disease mechanisms, poor targeting precision, and slow response times. Emerging technologies are now reshaping the landscape of antiviral research. This review examines the roles of four key frontiers, including organoid m...

Sep 5 2026 42700916
Combating New Delhi metallo-beta-lactamase-1 (NDM-1): an integrated review of inhibitor development and next-generation therapeutic platforms.

New Delhi metallo-β-lactamase-1 (NDM-1), which has emerged globally, exhibits resistance to almost all β-lactam antibiotics, including carbapenems, po...

Sep 4 2026 42699674
From Clinic to Home: Validating the Social Communication Scale for Telemedicine-Supported Early Autism Screening in Chinese Toddlers.

Telemedicine is reshaping how early autism detection can be delivered, particularly in resource-limited settings. Yet, most existing tele-assessment t...

Sep 4 2026 42695515
Immunoproteomic Profiling of Autoantibodies and Antibodies against Infectious Agents in Autoimmune Diseases.

Prior research investigated limited antibody sets within individual autoimmune diseases. Using the Nucleic-Acid Programmable Protein Array platform, w...

Sep 4 2026 42695874
Comparative analysis of human papilloma virus detection methods and prognostic significance of transcriptionally active viral load in oropharyngeal squamous cell carcinoma.

BACKGROUND: Human papilloma virus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is rising. Despite the prognostic and therapeu...

Sep 4 2026 42696859
ABAG-Rank: Improving Model Selection of AlphaFold Antibody-Antigen Complexes by Learning to Rank.

MOTIVATION: AlphaFold has transformed structural biology with an unprecedented accuracy in modelling protein structures and their interactions with bi...

Sep 4 2026 42693924
Development of a YOLO-guided automated (microplastic) particle analysis workflow.

Microplastics (MPs) are an emerging pollutant of global concern, creating an urgent need for rapid and accurate monitoring workflows. Deep learning-ba...

Sep 4 2026 42694007
Lightweight Transformer-based knowledge distillation framework for high-dimensional spatiotemporal radiomics in breast cancer risk prediction.

Breast cancer exhibits significant spatiotemporal heterogeneity. Traditional radiomics approaches usually rely on low-temporal-resolution imaging and ...

Sep 3 2026 42690533
A Reliability-Guided Fusion and Dynamic Dual-Domain Mask-Modulated Shearlet Network for Medical Image Segmentation.

Deep learning methods are becoming increasingly important for medical image segmentation. However, previous approaches often performed poorly in spati...

Sep 3 2026 42693333
Development of a Machine Learning Algorithm for Differential Diagnosis Between Primary Immune Thrombocytopenia and Connective Tissue Disease-Related Thrombocytopenia in Pediatric Patients.

BACKGROUND: To develop a machine learning model for early differentiation of primary immune thrombocytopenia (pITP) from connective tissue disease-rel...

Sep 3 2026 42687748
A novel approach to dyslexia detection: combining EEG data and cognitive tasks with advanced machine learning.

Existing dyslexia detection methods typically rely on either EEG or screening tests. This study introduces a multimodal two-stage methodology for dysl...

Sep 2 2026 42684128
Comparison of Pleomorphic Dermal Sarcoma to Advanced Cutaneous Squamous Cell Carcinoma and Soft-Tissue Sarcoma.

IMPORTANCE: Pleomorphic dermal sarcomas (PDSs) are classified as sarcomas; however, they share features with cutaneous carcinomas, such as presentatio...

Sep 2 2026 42684729
The human oral and airway viral genome catalog from metagenomes enables virome characterization informing respiratory health.

BACKGROUND: Viral communities of the upper aerodigestive tract represent an important component of the human microbial ecosystem but remain poorly cha...

Sep 2 2026 42685687
MicroNucML enables machine learning-based micronuclei segmentation and micronuclei-nuclei association.

Micronuclei (MN) are structures containing small DNA fragments that arise from mitotic errors or failed DNA repair and serve as markers of genome inst...

Sep 2 2026 42685691
3D epigenome of glial cell types in developing human cortex.

The human cortex is complex and heterogeneous, undergoing extensive expansion during development1,2. Our prior study of neurogenesis, including radial...

Sep 2 2026 42686907
The Rise of Regulatogens: A Crisis of Insouciance and Dilettantism in the Regulatory DART World-And How We Must Fix It.

Developmental and reproductive toxicity testing (DART) safety tests are expensive and time-consuming. The future of DART testing is trending toward in...

Sep 1 2026 42687116
Evaluation of a One-Step Serological Test for Lyme Disease.

BACKGROUND: Lyme disease, a vector-borne zoonosis caused by Borrelia species, is classified into early localized and late disseminated infection. Left...

Sep 1 2026 42678044
Evaluating the Influence of MCAT Scores on Medical Student Selection and Performance Using a Machine Learning Approach: Retrospective Cohort Study.

BACKGROUND: The Medical College Admission Test (MCAT) has been central to medical school admissions in North America, though its necessity in holistic...

Sep 1 2026 42679306
Integrating Target Prediction and Transcriptomic Analysis Identifies the AKR1C2-KRT8 Axis in Rotenone-Induced Dopaminergic Neuron Injury.

Parkinson's disease (PD) is a complex neurodegenerative disorder in which environmental toxins play a critical etiological role. Rotenone, a classical...

Sep 1 2026 42679909
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