COVID-19

Standard operating procedure for curation and clinical interpretation of variants in cancer.

Manually curated variant knowledgebases and their associated knowledge models are serving an increasingly important role in distributing and interpreting variants in cancer. These knowledgebases vary in their level of public accessibility, and the complexity of the models used to capture clinical knowledge. CIViC (Clinical Interpretation of Variants in Cancer - www.civicdb.org) is a fully open, fr...

Comparison of a Novel Homogeneous Cyclic Amp Assay and a Luciferase Assay for Measuring Stimulating Thyrotropin-Receptor Autoantibodies.

OBJECTIVE: Stimulating thyrotropin-receptor antibodies (TSAb) cause Graves' disease (GD). We tested a novel homogeneous fluorescent 3',5' cyclic adenine monophosphate (cAMP) assay for the detection of TSAb in a bioassay.

Brain age prediction using deep learning uncovers associated sequence variants.

Machine learning algorithms can be trained to estimate age from brain structural MRI. The difference between an individual's predicted and chronologic...

A dual-stream deep convolutional network for reducing metal streak artifacts in CT images.

Machine learning and deep learning are rapidly finding applications in the medical imaging field. In this paper, we address the long-standing problem ...

Machine Learning Approaches for the Prioritization of Genomic Variants Impacting Pre-mRNA Splicing.

Defects in pre-mRNA splicing are frequently a cause of Mendelian disease. Despite the advent of next-generation sequencing, allowing a deeper insight ...

Machine learning with multiparametric magnetic resonance imaging of the breast for early prediction of response to neoadjuvant chemotherapy.

In patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy (NAC), some patients achieve a complete pathologic response (pCR),...

Spatiotemporal dynamics of urbanization and cropland in the Nile Delta of Egypt using machine learning and satellite big data: implications for sustainable development.

The Nile Delta of Egypt is increasingly facing sustainability threats, due to a combination of nature- and human-induced changes in land cover and lan...

Ranking of non-coding pathogenic variants and putative essential regions of the human genome.

A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding ge...

Effect of bacterial endotoxin lipopolysaccharide treatment on duck Leydig cells.

This study aimed to investigate the effects of bacterial endotoxin lipopolysaccharide (LPS) on hormone production and gene expression in duck Leydig c...

Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents.

Genome Wide Association Studies (GWAS) have evaluated several genes related to vitamin D synthesis, metabolism and transport. They have proposed a ge...

A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine.

BACKGROUND: Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation...

Mounting Behaviour Recognition for Pigs Based on Deep Learning.

For both pigs in commercial farms and biological experimental pigs at breeding bases, mounting behaviour is likely to cause damage such as epidermal w...

Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses.

Global outbreaks caused by emerging or re-emerging arthropod-borne viruses (arboviruses) are becoming increasingly more common. These pathogens inclu...

Jointly Integrating VCF-Based Variants and OWL-Based Biomedical Ontologies in MongoDB.

The development of the next-generation sequencing (NGS) technologies has led to massive amounts of VCF (Variant Call Format) files, which have been th...

Perceptrons from memristors.

Memristors, resistors with memory whose outputs depend on the history of their inputs, have been used with success in neuromorphic architectures, part...

Antibiotic therapy in patients with high prostate-specific antigen: Is it worth considering? A systematic review.

: To address the question of whether antibiotic therapy can obviate the need for prostate biopsy (PBx) in patients presenting with high prostate-speci...

Hepatitis B surface antigen reduction as a result of switching from long-term entecavir administration to tenofovir.

BACKGROUND AND AIM: Loss of hepatitis B surface antigen (HBsAg) is an important goal in the treatment of chronic hepatitis B. We investigated whether ...

A Multi-Organ Nucleus Segmentation Challenge.

Generalized nucleus segmentation techniques can contribute greatly to reducing the time to develop and validate visual biomarkers for new digital path...

A machine learning approach for the identification of population-informative markers from high-throughput genotyping data: application to several pig breeds.

Single nucleotide polymorphisms (SNPs) able to describe population differences can be used for important applications in livestock, including breed as...

Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.

Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have promising utility in prevention and treatment of HIV-1 in...