COVID-19

Predicting Antibody-Antigen Affinity with a Dual-Level Representation Model.

MOTIVATION: Protein language models (pLMs) are critical for modeling antibody-antigen interactions, ...

Unlocking the black box: multimodal imaging and quantitative analysis of plant vesicular trafficking.

How do plants, lacking a central nervous system, translate environmental stimuli into physiological ...

Computational redesign of a thermostable T7 RNA polymerase.

T7 RNA polymerase (T7 RNAP) is a foundational enzyme for biotechnology, but its utility for many pot...

Survey of Computerized Adaptive Testing: a Machine Learning Perspective.

Computerized Adaptive Testing (CAT) offers an efficient and personalized method for assessing examin...

EEG based detection of schizophrenia using asymmetry of entropy and CNN-LSTM model.

Schizophrenia is a severe neuropsychiatric disorder with a significant impact on individual's real-l...

Precision immunotherapies for systemic lupus erythematosus: From pathogenic targets to translational horizons.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder in which aberrant B-cell a...

OSCAR: A Modular Open-Source Robotic Platform for Biological Laboratories.

Biological research often involves complex, repetitive, and high-throughput manipulations that are w...

Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer.

Chimeric antigen receptor (CAR) T-cell therapy holds great promise for patients with cancer, and the...

NAStructuralDB : structural database to facilitate computational studies of molecular modeling and recognition of proteins with special focus on antibody-antigen interactions.

Studying the interactions between antibodies and antigens is fundamental to the development of novel...

Deep learning-enhanced shoreline dynamics and vulnerability assessment in Niger Delta area of Nigeria.

Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies.

Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly speci...

Overcoming gastrointestinal mucosal barriers: Mechanistic innovations and technical advances in mucosal targeting strategies for animal oral vaccines.

Infectious diseases caused by pathogenic microorganisms (such as Escherichia coli, Avian influenza v...

Radiomics-based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study.

OBJECTIVE: To develop machine-learning models that incorporate clinical information and radiomics fe...

From tests to truth: A misclassification-aware machine learning framework for estimating brucellosis seroprevalence in wild canids.

Brucellosis is an important zoonotic disease affecting humans, livestock, and wildlife, yet prevalen...

Predictive divergence in machine learning models for clinical mortality risk: A multicohort study of covid-19 patients.

BACKGROUND: Machine learning (ML) algorithms are increasingly used in healthcare to support clinical...

Cross-Cultural Differences in Public Discourse on COVID-19 Vaccination in the United States and South Korea: Cross-Sectional Analysis Using Natural Language Processing.

BACKGROUND: The COVID-19 vaccine was introduced as a crucial tool to combat the pandemic. However, c...

From Antigen to Atlas: A Multi-omics, Single-Cell Pipeline for Discovering Safe and Effective CAR Targets in Ovarian Cancer.

Chimeric antigen receptor (CAR) T-cell therapy has achieved remarkable success in hematologic malign...

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype-Guided AI for ANKRD11 Missense Variants.

KBG syndrome (KBGS, OMIM #148050) is a rare genetic disorder caused by heterozygous truncating or mi...

Development and validation of case-finding algorithms for identifying patients with systemic lupus erythematosus in an administrative claim database from tertiary care centers in Japan.

OBJECTIVE: To develop and validate algorithms for identifying patients with systemic lupus erythemat...

Biosensor-based diagnosis for infectious diseases: Nano-enabled revolution.

Infectious diseases (IDs) pose a significant global health threat, exacerbated by the rise of multid...

CAR T-cells in hematologic malignancies: Advances, challenges, and future directions.

Chimeric antigen receptor (CAR) T-cell therapy has transformed the management of hematologic maligna...