COVID-19

Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus.

This study aimed at investigating the association between haemostatic biomarkers, proinflammatory, and anti-inflammatory cytokines with chronic kidney disease in type 1 diabetic patients. Patients were divided into two groups: with nephropathy (albuminuria ≥ 30 mg/g and/or GFR < 60 mL/min/1.73 m(2)), n = 65; and without nephropathy (albuminuria < 30 mg/g and GFR ≥ 60 mL/min/1.73 m(2)), n = 60. INF...

Artificial neural network modeling enhances risk stratification and can reduce downstream testing for patients with suspected acute coronary syndromes, negative cardiac biomarkers, and normal ECGs.

Despite uncertain yield, guidelines endorse routine stress myocardial perfusion imaging (MPI) for patients with suspected acute coronary syndromes, unremarkable serial electrocardiograms, and negative troponin measurements. In these patients, outcome prediction and risk stratification models could spare unnecessary testing. This study therefore investigated the use of artificial neural networks (A...

Organism burden, toxin concentration, and lactoferrin concentration do not distinguish between clinically significant and nonsignificant diarrhea in patients with Clostridium difficile.

Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We evaluated 4 biomarkers as surrogates for clinically signific...

Powerful Tests for Multi-Marker Association Analysis Using Ensemble Learning.

Multi-marker approaches have received a lot of attention recently in genome wide association studies and can enhance power to detect new associations ...

Automated Classification and Cluster Visualization of Genotypes Derived from High Resolution Melt Curves.

INTRODUCTION: High Resolution Melting (HRM) following PCR has been used to identify DNA genotypes. Fluorescent dyes bounded to double strand DNA lose ...

Kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with Toxocara canis.

An evaluation was made of the kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with embryonated Toxocara cani...

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence.

Oral tongue squamous cell carcinomas (OTSCC) are a homogeneous group of tumors characterized by aggressive behavior, early spread to lymph nodes and a...

Prostate-specific antigen kinetics after stereotactic body radiotherapy as monotherapy or boost after whole pelvic radiotherapy for localized prostate cancer.

PURPOSE: Stereotactic body radiotherapy (SBRT) has emerged as an effective treatment for localized prostate cancer. However, prostate-specific antigen...

Prevalence and Viral Load of Human Parvovirus B19 (B19V) Among Blood Donors in South-East Brazil.

The infection of human parvovirus B19 (B19V) is a common event in the general population, including volunteer blood donors. In some cases it can be as...

Multiple Testing of Gene Sets from Gene Ontology: Possibilities and Pitfalls.

The use of multiple testing procedures in the context of gene-set testing is an important but relatively underexposed topic. If a multiple testing met...

Prioritizing Clinically Relevant Copy Number Variation from Genetic Interactions and Gene Function Data.

It is becoming increasingly necessary to develop computerized methods for identifying the few disease-causing variants from hundreds discovered in eac...

Fuzzy Logic Based Edge Detection in Smooth and Noisy Clinical Images.

Edge detection has beneficial applications in the fields such as machine vision, pattern recognition and biomedical imaging etc. Edge detection highli...

3D printing antagonistic systems of artificial muscle using projection stereolithography.

The detailed mechanical design of a digital mask projection stereolithgraphy system is described for the 3D printing of soft actuators. A commercially...

Knockdown of NADPH-cytochrome P450 reductase results in reduced resistance to buprofezin in the small brown planthopper, Laodelphax striatellus (fallén).

NADPH-cytochrome P450 reductase (CPR) plays an important role in cytochrome P450 function, and CPR knockdown in several insects leads to increased sus...

Development of molecular approach based on PCR assay for detection of histamine producing bacteria.

Histamine fish poisoning becomes highly concern not only in public health but also economic aspect. Histamine is produced from histidine in fish muscl...

A Comparative Study on Multifactor Dimensionality Reduction Methods for Detecting Gene-Gene Interactions with the Survival Phenotype.

Genome-wide association studies (GWAS) have extensively analyzed single SNP effects on a wide variety of common and complex diseases and found many ge...

Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis.

Genome-wide association studies have revealed a vast amount of common loci associated to human complex diseases. Still, a large proportion of heritabi...

Pairwise Constraint-Guided Sparse Learning for Feature Selection.

Feature selection aims to identify the most informative features for a compact and accurate data representation. As typical supervised feature selecti...

Better prediction of functional effects for sequence variants.

Elucidating the effects of naturally occurring genetic variation is one of the major challenges for personalized health and personalized medicine. Her...

Support vector machine in crash prediction at the level of traffic analysis zones: Assessing the spatial proximity effects.

In zone-level crash prediction, accounting for spatial dependence has become an extensively studied topic. This study proposes Support Vector Machine ...