Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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OracleScreen-LILRB4: Machine Learning-Guided Discovery of Myeloid Immune Checkpoint Binders Validated in Patient-Derived Cells

The identification of small molecule modulators of immune checkpoint proteins remains a significant challenge in drug discovery due to the flat, featureless nature of protein-protein interaction interfaces and the characteristically low hit rates observed in conventional high-throughput screening campaigns. Here we report OracleScreen-LILRB4, an ensemble machine learning framework trained on quant...

Bioinf-Farma: supervised integration of epitope prediction and recombinant protein developability for automated vaccine candidate prioritization

Vaccine antigen discovery requires prioritizing protein candidates according to both immunogenic potential and recombinant expression feasibility. These properties are typically evaluated using separate computational tools, requiring researchers to integrate heterogeneous outputs through ad hoc workflows. Here, we present BIOINF-farma, a modular platform integrating epitope prediction and developa...

ParaScale: Scale-Calibrated Camera-Motion Transfer via a Gauge-Invariant Parallax Number

Transferring the camera motion of a reference video to a freshly generated one lets creators reuse cinematic moves. Yet reference and target often liv...

Jun 18 2026 2606.19805v1
ARTEMIS: Agent-guided Reliability-aware Temporal Mask Evolution for Imperfectly Supervised Video Polyp Segmentation

Imperfectly supervised video polyp segmentation (VPS) aims to learn dense, temporally consistent masks from inexpensive supervision, including weak an...

Jun 18 2026 2606.20161v1
What Urine Measures Is Not What Tissue Encodes: Compartment-Specific miRNA Coordination in Prostate Cancer

Abstract Background Prostate cancer (PCa) diagnosis remains challenged by the limited specificity of prostate-specific antigen (PSA) testing, which ca...

Machine learning-guided olivetolic acid cyclase engineering enables tailored cannabinoid biosynthesis in yeast

Cannabinoids comprise a diverse class of bioactive natural products with important therapeutic potential, but efficient microbial production remains l...

CABLE: Cloud-Assisted Bandwidth-efficient LMM-based Encoding for V2X Systems

Cloud-hosted large multimodal models (LMMs) can provide strong open-vocabulary perception for Vehicle-to-Everything systems, but naively transmitting ...

Jun 17 2026 2606.19258v1
DeltaQ: Value-Guided Hebbian Learning in Spiking Neuronal Networks for Multi-Goal Navigation

Animals must often navigate environments where feedback about progress toward a goal is sparse or delayed, requiring internal representations of space...

A data-driven consensus framework for Ct interpretation in real-world multi-assay qPCR diagnostics

While cycle threshold (Ct) values from quantitative PCR (qPCR) serve as the gold-standard indicators of target abundance, their clinical interpretatio...

GLLaucoMed: A Secure LLM-Powered Agentic Workflow for Automated Medication Extraction from Free-Text Glaucoma Clinical Notes

Purpose: To evaluate the efficacy of large language models (LLMs) in extracting medication-related information from glaucoma clinical notes in the ele...

Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model

T cell receptor (TCR)-based immunotherapy holds immense potential for treating cancers and infectious diseases, where highly antigen-specific TCR reco...

Agreement of an AI tool for joint space width measurement in radiographic knee osteoarthritis: data from the LOSEIT trial

Background and rationale: Knee osteoarthritis (KOA) is a leading cause of lower limb disability worldwide, characterized by functional limitations, st...

MAHLER: Integrating Metadynamics and Inverse Folding to Predict Antibody-Antigen Kinetics

Binding kinetics are crucial for antibody function, shaping pharmacokinetics and in vivo efficacy beyond what equilibrium affinity captures. We presen...

Leveraging genome-wide association studies and genomic prediction for distinctness, uniformity, and stability (DUS) testing in maize

Testing for distinctness, uniformity, and stability (DUS) is a requirement for plant variety registration and based on phenotypic traits, which is tim...

Is It You or Your Environment? A Bayesian Inference Framework for Genomically-Anchored Personalized Physiological Interpretation

Personalized health AI systems face a fundamental cold-start problem: machine learning models for physiological interpretation require weeks of indivi...

Jun 11 2026 2606.13556v2
Explaining RhythmFormer: A Systematic XAI Analysis of Periodic Sparse Attention for Remote Photoplethysmography

Remote photoplethysmography (rPPG) transformers achieve low heart-rate error on benchmarks, yet their decisions remain opaque--a growing concern as rP...

Jun 11 2026 2606.13839v1
HiLo-Token: Input-Adaptive High-Low Frequency Token Compression for Efficient Image Editing

Creative image editing tools, such as Photoshop's Remove or Generative Fill buttons, are central to everyday customer use and account for a major shar...

Jun 11 2026 2606.13898v1
Overhead Wildlife Locator (OWL): Benchmarking Weakly Supervised Learning for Aerial Wildlife Surveys

Automated aerial wildlife surveys increasingly rely on deep learning, yet standard object detectors require bounding-box annotations, reported to be u...

Jun 11 2026 2606.13911v1
Computer Vision Scoring of Figure Copy and Recall

Objective. Figure copy and recall tests are sensitive measures of visuoconstruction and visual episodic memory, but their clinical is constrained by l...

DeePEn - A Depth sensitive benchmark for Protein Engineering

Recent progress in modeling techniques and high-throughput screening has significantly enhanced the accessibility of protein engineering. Nevertheless...

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