Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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Functional Profiling of Thousands of Sequence-Diverse Protease Homologs with GROQ-seq

High-quality datasets that span broad sequence diversity are essential for understanding protein sequence-function relationships beyond local mutational landscapes. Here, we applied Growth-based Quantitative Sequencing (GROQ-seq) to measure function across an 11,722 member protease library, comprised of natural homologs and AI-shrunken variants. This library spans vast sequence diversity, with Lev...

deSEO: Physics-Aware Dataset Creation for High-Resolution Satellite Image Shadow Removal

Shadows cast by terrain and tall structures remain a major obstacle for high-resolution satellite image analysis, degrading classification, detection, and 3D reconstruction performance. Public resources offering geometry-consistent paired shadow/shadow-free satellite imagery are essentially missing, and most Earth-observation datasets are designed for shadow detection or 3D modelling rather than r...

May 5 2026 2605.03610v1
Uncertainty Estimation in Instance Segmentation of Affordances via Bayesian Visual Transformers

Visual affordances identify regions in an image with potential interactions, offering a novel paradigm for scene understanding. Recognizing affordance...

May 5 2026 2605.03614v1
Biological Spatial Priors Regularize Foundation Model Representations for Cross-Site MSI Generalization in Colorectal Cancer

Predicting microsatellite instability (MSI) status from routine hematoxylin and eosin (H&E) whole slide images (WSIs) offers a practical alternative t...

May 4 2026 2605.02660v1
Joint Variable Selection for Omic Biomarkers in Time-to-Event Data

The incidence of the vast majority of neurodegenerative, cancer, and metabolic diseases generally increases exponentially with age. In large-scale bio...

Exploring the Limits of End-to-End Feature-Affinity Propagation for Single-Point Supervised Infrared Small Target Detection

Single-point supervised infrared small target detection (IRSTD) drastically reduces dense annotation costs. Current state-of-the-art (SOTA) methods ac...

May 1 2026 2605.00722v1
Tuned inhibitory control of neuronal firing thresholds explains predictive sensorimotor behavior

Prior expectations guide sensorimotor behavior when sensory information is uncertain, yet the cellular mechanisms underlying this integration remain e...

Remote SAMsing: From Segment Anything to Segment Everything

SAM2 produces high-quality zero-shot segmentation on natural images, but applying it to large remote sensing scenes exposes two problems: (1) its mask...

Apr 30 2026 2605.00256v1
Overcoming systematic data biases enables accurate prediction of enzyme kcat fold-changes for computational protein design

Machine learning is increasingly used to guide protein engineering by predicting how mutations affect desired properties. Recent models for the turnov...

Artificial Intelligence for Cardiac Biomarkers After Myocardial Infarction: A Systematic Review and a Leakage-Aware Modeling Framework

Aims To systematically evaluate how artificial intelligence and machine-learning (AI/ML) methods are applied to cardiac biomarkers after myocardial in...

Explainable Prototype Booster: Enhancing Latent Representations of Foundation Models for Gene Expression Prediction

Spatial transcriptomics (ST) is a cutting-edge technology that measures gene expression while preserving spatial context and generating pathology-grad...

Are Data Augmentation and Segmentation Always Necessary? Insights from COVID-19 X-Rays and a Methodology Thereof

Purpose: Rapid and reliable diagnostic tools are crucial for managing respiratory diseases like COVID-19, where chest X-ray analysis coupled with arti...

Apr 29 2026 2604.26437v1
Delta Score Matters! Spatial Adaptive Multi Guidance in Diffusion Models

Diffusion models have achieved remarkable success in synthesizing complex static and temporal visuals, a breakthrough largely driven by Classifier-Fre...

Apr 29 2026 2604.26503v1
Deep-testing: the case of dependence detection

Deep learning methods have proved highly effective for classification and image recognition problems. In this paper, we ask whether this success can b...

Apr 29 2026 2604.26558v1
Detection of bronchopulmonary dysplasia in infants and prediction of school-age lung function from tidal breathing data using recurrent neural networks

Objective: To test whether machine learning (ML) models trained on tidal breathing flow time series can discriminate between individuals with and with...

Screening for patients at risk for cardiac amyloidosis via electronic health records: A multicenter machine learning development and validation study

Background Timely detection is crucial to improve outcomes in patients with cardiac amyloidosis (CA) by initiation of life-saving treatments. Although...

One Perturbation, Two Failure Modes: Probing VLM Safety via Embedding-Guided Typographic Perturbations

Typographic prompt injection exploits vision language models' (VLMs) ability to read text rendered in images, posing a growing threat as VLMs power au...

Apr 28 2026 2604.25102v1
UshEffect-3D: Structure-informed Classification of USH2A Missense Variants for Inherited Retinal Disease

Variants of uncertain significance (VUS) in USH2A represent a critical interpretive challenge in inherited retinal disease, with over 70% of ClinVar s...

Combining AI structure prediction and integrative modelling for nanobody-antigen complexes

Nanobodies exhibit antigen binding a[ffi]nities of the same order as those of antibodies, which, along with their small size and unique structural cha...

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