Infectious Disease

COVID-19

Latest AI and machine learning research in covid-19 for healthcare professionals.

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A Clinical Theory-Driven Deep Learning Model for Interpretable Autism Severity Prediction

Autism spectrum disorder (ASD) affects a substantial proportion of children worldwide, yet clinical assessment of symptom severity remains resource-intensive and unevenly accessible. Artificial intelligence (AI) has transformative potential to support scalable and timely severity assessment from behavioral data, but existing approaches largely treat autism as a monolithic prediction target and rel...

Learning with Geometric Priors in U-Net Variants for Polyp Segmentation

Accurate and robust polyp segmentation is essential for early colorectal cancer detection and for computer-aided diagnosis. While convolutional neural network-, Transformer-, and Mamba-based U-Net variants have achieved strong performance, they still struggle to capture geometric and structural cues, especially in low-contrast or cluttered colonoscopy scenes. To address this challenge, we propose ...

Jan 24 2026 2601.17331v1
AlphaGenome -enabled analysis of non-coding regulatory variants underlying RHD Expression

Systematic identification of functional non-coding regulatory variants remains a major challenge in human genetics. Conventional approaches such as la...

TCRAD: An End-to-End Framework for Antigen-Targeted T Cell Receptor Design

Understanding and engineering T-cell receptor (TCR) specificity is central to personalized immunotherapy and antigen discovery. However, while antigen...

LLM is Not All You Need: A Systematic Evaluation of ML vs. Foundation Models for text and image based Medical Classification

The combination of multimodal Vision-Language Models (VLMs) and Large Language Models (LLMs) opens up new possibilities for medical classification. Th...

Jan 23 2026 2601.16549v1
Reprogramming BCMA-Targeted CAR-T Cells through γ-Secretase Modulation Blocks Antigen Shedding and Extends CAR-T Longevity

B-cell maturation antigen (BCMA) shedding by {gamma}-secretase generates soluble BCMA (sBCMA) , which diminishes membrane antigen density, and limits ...

ARID-sf: A physics-informed Deep Learning scoring function to improve Antibody-Antigen docking model ranking

Accurate prediction of antibody-antigen (Ab-Ag) complexation is crucial for understanding immune responses, diagnostics, and the development of therap...

DCCVT: Differentiable Clipped Centroidal Voronoi Tessellation

While Marching Cubes (MC) and Marching Tetrahedra (MTet) are widely adopted in 3D reconstruction pipelines due to their simplicity and efficiency, the...

Jan 20 2026 2601.13603v1
COLLEMBOT: AI-Based Counting of Collembola for OECD 232 Tests

Ecotoxicological tests with soil organisms, such as the collembolan Folsomia candida, are essential for assessing chemical risks in terrestrial ecosys...

A Generalist Foundation Model for Total-body PET/CT Enables Diagnostic Reporting and System-wide Metabolic Profiling

Total-body PET/CT enables system-wide molecular imaging, but heterogeneous anatomical and metabolic signals, approximately 2 m axial coverage, and str...

Jan 19 2026 2601.12820v1
Prototype Learning-Based Few-Shot Segmentation for Low-Light Crack on Concrete Structures

Crack detection is critical for concrete infrastructure safety, but real-world cracks often appear in low-light environments like tunnels and bridge u...

Jan 19 2026 2601.13059v1
Pharmacogenomic Determinants of Post-Liver Transplant Diabetes Mellitus: A Systematic Review and In Silico Pharmacogenomic Analysis

Introduction: Tacrolimus remains central to liver transplantation, yet its narrow therapeutic index and pharmacokinetic variability are associated wit...

Beyond the Dirac Delta: Mitigating Diversity Collapse in Reinforcement Fine-Tuning for Versatile Image Generation

Reinforcement learning (RL) has emerged as a powerful paradigm for fine-tuning large-scale generative models, such as diffusion and flow models, to al...

Jan 18 2026 2601.12401v1
SE3Bind: SE(3)-equivariant model for antibody-antigen binding affinity prediction

Predicting antibody-antigen binding affinity is critical for therapeutic development, but machine learning-based approaches to the problem are typical...

Segment and Matte Anything in a Unified Model

Segment Anything (SAM) has recently pushed the boundaries of segmentation by demonstrating zero-shot generalization and flexible prompting after train...

Jan 17 2026 2601.12147v1
Transmission Dynamics of Eastern Equine Encephalitis Infection Rates: The Role of Avian Host Stage and Differential Mosquito Exposure

Eastern equine encephalitis virus (EEEV) is a deadly arboviral pathogen with 30% severe case fatality. EEEV exhibits pronounced 2-3 year cyclical outb...

Sparse Data Tree Canopy Segmentation: Fine-Tuning Leading Pretrained Models on Only 150 Images

Tree canopy detection from aerial imagery is an important task for environmental monitoring, urban planning, and ecosystem analysis. Simulating real-l...

Jan 16 2026 2601.10931v1
Context-Aware Semantic Segmentation via Stage-Wise Attention

Semantic ultra high resolution image (UHR) segmentation is essential in remote sensing applications such as aerial mapping and environmental monitorin...

Jan 16 2026 2601.11310v1
Leveraging Unified Sequence-Structure Representations for Enhanced Protein Stability Prediction

Protein thermal stability, quantified by the change in Gibbs free energy ({Delta}{Delta}G) upon mutation, is critical for drug design and enzyme engin...

Jordan-Segmentable Masks: A Topology-Aware definition for characterizing Binary Image Segmentation

Image segmentation plays a central role in computer vision. However, widely used evaluation metrics, whether pixel-wise, region-based, or boundary-foc...

Jan 15 2026 2601.10577v2
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